The anti-diabetic drug exenatide, a glucagon-like peptide-1 receptor agonist, counteracts hepatocarcinogenesis through cAMP-PKA-EGFR-STAT3 axis.

Zhou M, Mok MT, Sun H, Chan AW, Huang Y, Cheng AS, Xu G

Oncogene20 Mar 2017Cited by 51 (Europe PMC)

PMID28319060DOI10.1038/onc.2017.38PepBankPUB-28319060

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In obese DEN-treated mice, Ex-4 improved obesity-induced hyperglycemia.
In plain wordsIn obese DEN-treated mice, Ex-4 improved high blood glucose.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseHyperglycemia
Study
mousen: not reported in source
Obese DEN-treated mice
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Administration of Ex-4 significantly improved obesity-induced hyperglycemia and hyperlipidemia and reduced HCC multiplicity in obese DEN-treated mice, in which suppressed proliferation and induced apoptosis were confined to tumor cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effect of Ex-4 in diethylnitrosamine (DEN)-treated mice consuming control or high-fat high-carbohydrate diet.
Report a problemFND-2831906001
02AnimalAnimal study (in vivo)Efficacy outcome
In obese DEN-treated mice, Ex-4 improved obesity-induced hyperlipidemia.
In plain wordsIn obese DEN-treated mice, Ex-4 improved high blood lipid levels.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseHyperlipidemia
Study
mousen: not reported in source
Obese DEN-treated mice
Outcome group
Lipids · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Administration of Ex-4 significantly improved obesity-induced hyperglycemia and hyperlipidemia and reduced HCC multiplicity in obese DEN-treated mice, in which suppressed proliferation and induced apoptosis were confined to tumor cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effect of Ex-4 in diethylnitrosamine (DEN)-treated mice consuming control or high-fat high-carbohydrate diet.
Report a problemFND-2831906002
03AnimalAnimal study (in vivo)Efficacy outcome
In obese DEN-treated mice, Ex-4 reduced hepatocellular carcinoma multiplicity.
In plain wordsIn obese DEN-treated mice, Ex-4 reduced liver tumor multiplicity.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseHepatocellular carcinoma multiplicity
Study
mousen: not reported in source
Obese DEN-treated mice
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Administration of Ex-4 significantly improved obesity-induced hyperglycemia and hyperlipidemia and reduced HCC multiplicity in obese DEN-treated mice, in which suppressed proliferation and induced apoptosis were confined to tumor cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effect of Ex-4 in diethylnitrosamine (DEN)-treated mice consuming control or high-fat high-carbohydrate diet.
Report a problemFND-2831906003
04AnimalAnimal study (in vivo)Efficacy outcome
In obese DEN-treated mice, Ex-4 suppressed proliferation confined to tumor cells.
In plain wordsIn obese DEN-treated mice, Ex-4 suppressed tumor cell multiplication.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseTumor cell proliferation
Study
mousen: not reported in source
Obese DEN-treated mice
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Administration of Ex-4 significantly improved obesity-induced hyperglycemia and hyperlipidemia and reduced HCC multiplicity in obese DEN-treated mice, in which suppressed proliferation and induced apoptosis were confined to tumor cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effect of Ex-4 in diethylnitrosamine (DEN)-treated mice consuming control or high-fat high-carbohydrate diet.
Report a problemFND-2831906004
05AnimalAnimal study (in vivo)Efficacy outcome
In obese DEN-treated mice, Ex-4 induced apoptosis confined to tumor cells.
In plain wordsIn obese DEN-treated mice, Ex-4 induced tumor cell death.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseTumor cell apoptosis
Study
mousen: not reported in source
Obese DEN-treated mice
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Administration of Ex-4 significantly improved obesity-induced hyperglycemia and hyperlipidemia and reduced HCC multiplicity in obese DEN-treated mice, in which suppressed proliferation and induced apoptosis were confined to tumor cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effect of Ex-4 in diethylnitrosamine (DEN)-treated mice consuming control or high-fat high-carbohydrate diet.
Report a problemFND-2831906005
06AnimalAnimal study (in vivo)Mechanism
In obese DEN-treated mice, Ex-4 tumor suppression was associated with high GLP-1R expression.
In plain wordsIn obese DEN-treated mice, Ex-4 tumor suppression was linked to high GLP-1 receptor expression.
Peptide
Exenatide (exendin-4)
Outcome
Not applicableGLP-1R expression association
Study
mousen: not reported in source
Obese DEN-treated mice
Outcome group
Receptor activity and mechanism · Cancer
Studied dose
Dose not stated
Source sentences
Summary
The tumor suppression effects of Ex-4 were associated with high expression of GLP-1R and activation of cyclic AMP (cAMP) and protein kinase A (PKA).
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effect of Ex-4 in diethylnitrosamine (DEN)-treated mice consuming control or high-fat high-carbohydrate diet.
Report a problemFND-2831906006
07AnimalAnimal study (in vivo)Mechanism
In obese DEN-treated mice, Ex-4 tumor suppression was associated with cAMP activation.
In plain wordsIn obese DEN-treated mice, Ex-4 tumor suppression was linked to cAMP activation.
Peptide
Exenatide (exendin-4)
Outcome
IncreasecAMP activation
Study
mousen: not reported in source
Obese DEN-treated mice
Outcome group
Receptor activity and mechanism · Cancer
Studied dose
Dose not stated
Source sentences
Summary
The tumor suppression effects of Ex-4 were associated with high expression of GLP-1R and activation of cyclic AMP (cAMP) and protein kinase A (PKA).
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effect of Ex-4 in diethylnitrosamine (DEN)-treated mice consuming control or high-fat high-carbohydrate diet.
Report a problemFND-2831906007
08AnimalAnimal study (in vivo)Mechanism
In obese DEN-treated mice, Ex-4 tumor suppression was associated with PKA activation.
In plain wordsIn obese DEN-treated mice, Ex-4 tumor suppression was linked to PKA activation.
Peptide
Exenatide (exendin-4)
Outcome
IncreasePKA activation
Study
mousen: not reported in source
Obese DEN-treated mice
Outcome group
Receptor activity and mechanism · Cancer
Studied dose
Dose not stated
Source sentences
Summary
The tumor suppression effects of Ex-4 were associated with high expression of GLP-1R and activation of cyclic AMP (cAMP) and protein kinase A (PKA).
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effect of Ex-4 in diethylnitrosamine (DEN)-treated mice consuming control or high-fat high-carbohydrate diet.
Report a problemFND-2831906008
09AnimalAnimal study (in vivo)Mechanism
In the hepatocarcinogenesis study, Ex-4 downregulated EGFR.
In plain wordsIn mice, Ex-4 reduced EGFR in the liver cancer study.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseEGFR downregulation
Study
mousen: not reported in source
Obese DEN-treated mice
Outcome group
Receptor activity and mechanism · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Importantly, Ex-4 also downregulated epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3), which lie downstream of cAMP-PKA signaling, resulting in suppression of multiple STAT3-targeted genes including c-Myc, cyclin D1, survivin, Bcl-2 and Bcl-xl.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effect of Ex-4 in diethylnitrosamine (DEN)-treated mice consuming control or high-fat high-carbohydrate diet.
Report a problemFND-2831906009
10AnimalAnimal study (in vivo)Mechanism
In the hepatocarcinogenesis study, Ex-4 downregulated STAT3.
In plain wordsIn mice, Ex-4 reduced STAT3 in the liver cancer study.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseSTAT3 downregulation
Study
mousen: not reported in source
Obese DEN-treated mice
Outcome group
Receptor activity and mechanism · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Importantly, Ex-4 also downregulated epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3), which lie downstream of cAMP-PKA signaling, resulting in suppression of multiple STAT3-targeted genes including c-Myc, cyclin D1, survivin, Bcl-2 and Bcl-xl.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effect of Ex-4 in diethylnitrosamine (DEN)-treated mice consuming control or high-fat high-carbohydrate diet.
Report a problemFND-2831906010
11AnimalAnimal study (in vivo)Mechanism
In the hepatocarcinogenesis study, Ex-4 suppressed STAT3-targeted genes including c-Myc, cyclin D1, survivin, Bcl-2 and Bcl-xl.
In plain wordsIn mice, Ex-4 suppressed several STAT3-targeted genes in the liver cancer study.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseSTAT3-targeted gene suppression
Study
mousen: not reported in source
Obese DEN-treated mice
Outcome group
Receptor activity and mechanism · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Importantly, Ex-4 also downregulated epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3), which lie downstream of cAMP-PKA signaling, resulting in suppression of multiple STAT3-targeted genes including c-Myc, cyclin D1, survivin, Bcl-2 and Bcl-xl.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effect of Ex-4 in diethylnitrosamine (DEN)-treated mice consuming control or high-fat high-carbohydrate diet.
Report a problemFND-2831906011
12AnimalAnimal study (in vivo)Efficacy outcome
In a xenograft mouse model, Ex-4 inhibited growth, with PKA and EGFR required for its effects.
In plain wordsIn mice with tumor grafts, Ex-4 inhibited growth, with PKA and EGFR required for its effects.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseXenograft growth
Study
mousen: not reported in source
Xenograft mouse model
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
The growth inhibitory effects of Ex-4 were consistent in GLP-1R-abundant hepatoma cell lines and xenograft mouse model, wherein both PKA and EGFR had obligatory roles in mediating Ex-4 functions.
Report a problemFND-2831906013
13AnimalAnimal study (in vivo)Efficacy outcome
In mice fed methionine-choline-deficient diet, Ex-4 suppressed inflammatory phenotypes.
In plain wordsIn mice fed methionine-choline-deficient diet, Ex-4 suppressed inflammatory changes.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseInflammatory phenotype
Study
mousen: not reported in source
Mice fed methionine-choline-deficient diet
Outcome group
Inflammation markers · Liver
Studied dose
Dose not stated
Source sentences
Summary
In addition, Ex-4 also effectively suppressed inflammatory and fibrotic phenotypes in mice fed with methionine-choline-deficient (MCD) diet and choline-deficient ethionine-supplemented (CDE) diet, respectively.
Report a problemFND-2831906014
14AnimalAnimal study (in vivo)Efficacy outcome
In mice fed choline-deficient ethionine-supplemented diet, Ex-4 suppressed fibrotic phenotypes.
In plain wordsIn mice fed choline-deficient ethionine-supplemented diet, Ex-4 suppressed fibrotic changes.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseFibrotic phenotype
Study
mousen: not reported in source
Mice fed choline-deficient ethionine-supplemented diet
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
In addition, Ex-4 also effectively suppressed inflammatory and fibrotic phenotypes in mice fed with methionine-choline-deficient (MCD) diet and choline-deficient ethionine-supplemented (CDE) diet, respectively.
Report a problemFND-2831906015
15LabIn vitro (cells)Efficacy outcome
In GLP-1R-abundant hepatoma cell lines, Ex-4 inhibited growth, with PKA and EGFR required for its effects.
In plain wordsIn cells, Ex-4 inhibited liver cancer cell growth, with PKA and EGFR required for its effects.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseHepatoma cell growth
Study
n: not reported in source
GLP-1R-abundant hepatoma cell lines
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
The growth inhibitory effects of Ex-4 were consistent in GLP-1R-abundant hepatoma cell lines and xenograft mouse model, wherein both PKA and EGFR had obligatory roles in mediating Ex-4 functions.
Report a problemFND-2831906012

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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