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Study · Animal study (in vivo) · rat · 2017

3 results

Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia.

Conte E, Camerino GM, Mele A, De Bellis M, Pierno S, Rana F, Fonzino A, Caloiero R, Rizzi L, Bresciani E, Ben Haj Salah K, Fehrentz JA and 10 more

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Martinez J, Giustino A, Mariggiò MA, Coluccia M, Tricarico D, Lograno MD, De Luca A, Torsello A, Conte D, Liantonio A

Journal of cachexia, sarcopenia and muscle10 Mar 2017Cited by 62 (Europe PMC)

PMID28294567 (opens in a new tab)PMCIDPMC5703021 (opens in a new tab)DOI10.1002/jcsm.12185 (opens in a new tab)PepBankPUB-28294567
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with cisplatin-induced cachexia, hexarelin markedly reduced the cisplatin-induced alteration of skeletal muscle calcium homeostasis.

    In plain wordsIn rats with cisplatin-induced muscle wasting, hexarelin greatly reduced the disturbance of calcium handling in muscle.

    Peptide
    Hexarelin
    Outcome
    DecreaseCisplatin-induced alteration of calcium homeostasis in muscle
    Study

    ratn: not reported in source

    Rat model of cisplatin-induced cachexia (EDL muscle)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of hexarelin or JMV2894 markedly reduced the cisplatin-induced alteration of calcium homeostasis by both common as well as drug-specific mechanisms of action.
    1 context sentence
    Summary · context
    By a multidisciplinary approach ranging from cytofluorometry and electrophysiology to gene expression and histology, we characterized the calcium homeostasis in fast-twitch extensor digitorum longus (EDL) muscle of adult rats with cisplatin-induced cachexia and established the potential beneficial e…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cisplatin-induced cachexia, hexarelin treatment was linked to preservation of muscle function.

    In plain wordsIn rats with cisplatin-induced muscle wasting, hexarelin treatment was linked to better muscle function.

    Peptide
    Hexarelin
    Outcome
    IncreaseMuscle function preservation
    Study

    ratn: not reported in source

    Rat model of cisplatin-induced cachexia (EDL muscle)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This effect correlated with muscle function preservation as well as amelioration of various atrophic indexes, thus supporting the functional impact of GHS activity on calcium homeostasis.
    2 context sentences
    Summary · context
    Additionally, in vivo measures of grip strength and of ultrasonography recordings allowed us to evaluate the functional impact of GHS therapeutic intervention.
    Summary · context
    By a multidisciplinary approach ranging from cytofluorometry and electrophysiology to gene expression and histology, we characterized the calcium homeostasis in fast-twitch extensor digitorum longus (EDL) muscle of adult rats with cisplatin-induced cachexia and established the potential beneficial e…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cisplatin-induced cachexia, hexarelin treatment was linked to amelioration of various muscle atrophy indexes.

    In plain wordsIn rats with cisplatin-induced muscle wasting, hexarelin treatment was linked to milder signs of muscle atrophy.

    Peptide
    Hexarelin
    Outcome
    DecreaseAtrophic indexes in muscle
    Study

    ratn: not reported in source

    Rat model of cisplatin-induced cachexia (EDL muscle)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This effect correlated with muscle function preservation as well as amelioration of various atrophic indexes, thus supporting the functional impact of GHS activity on calcium homeostasis.
    1 context sentence
    Summary · context
    By a multidisciplinary approach ranging from cytofluorometry and electrophysiology to gene expression and histology, we characterized the calcium homeostasis in fast-twitch extensor digitorum longus (EDL) muscle of adult rats with cisplatin-induced cachexia and established the potential beneficial e…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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