Kisspeptin-10 treatment generated specific GnRH expression in cells differentiated from rhesus monkey derived Lyon NSCs.

Huma T, Hu X, Ma Y, Willden A, Rizak J, Shahab M, Wang Z

Neuroscience10 Mar 2017Cited by 4 (Europe PMC)

PMID28288899DOI10.1016/j.neuroscience.2017.03.004PepBankPUB-28288899

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In rhesus macaque-derived Lyon embryonic stem cells, kisspeptin‑10 had an anti-proliferative effect.
In plain wordsIn rhesus monkey stem cells in the lab, kisspeptin‑10 slowed cell growth.
Peptide
Kisspeptin-10
Outcome
DecreaseCell proliferation
Study
rhesus macaquen: not reported in source
Lyon embryonic stem cell-derived neuronal stem cells
Outcome group
Cell proliferation and differentiation · Whole body
Studied dose
Dose not stated
Source sentences
Summary
KP-10 exhibited an anti-proliferative effect on the cells
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, a kisspeptin peptide (KP-10) was used at different dosages to determine whether rhesus macaque-derived tau GFP-Lyon ES cells underwent kisspeptin-specific neuronal differentiation.
Report a problemFND-2828889901
02LabIn vitro (cells)Mechanism
In rhesus macaque-derived Lyon embryonic stem cells, kisspeptin‑10 led to morphological changes and differentiation consistent with neuronal stem cell development.
In plain wordsIn rhesus monkey stem cells in the lab, kisspeptin‑10 changed cell shape in a way that fits nerve stem cell development.
Peptide
Kisspeptin-10
Outcome
Not applicableNeuronal stem cell differentiation
Study
rhesus macaquen: not reported in source
Lyon embryonic stem cell-derived neuronal stem cells
Outcome group
Cell proliferation and differentiation · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
led to morphological changes and cellular differentiation consistent with neuronal stem cell (NSC) development.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, a kisspeptin peptide (KP-10) was used at different dosages to determine whether rhesus macaque-derived tau GFP-Lyon ES cells underwent kisspeptin-specific neuronal differentiation.
Report a problemFND-2828889902
03LabIn vitro (cells)Mechanism
In rhesus macaque-derived Lyon embryonic stem cells, kisspeptin‑10 treatment gave cells that resembled GnRH neurons.
In plain wordsIn rhesus monkey stem cells in the lab, kisspeptin‑10 made cells that looked like GnRH nerve cells.
Peptide
Kisspeptin-10
Outcome
Not applicableDifferentiation into GnRH neuronal-like cells
Study
rhesus macaquen: not reported in source
Lyon embryonic stem cell-derived neuronal stem cells
Outcome group
Cell proliferation and differentiation · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The cells differentiated into Gonadotrophin Releasing Hormone (GnRH) neuronal-like cell types in response to the KP-10 treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, a kisspeptin peptide (KP-10) was used at different dosages to determine whether rhesus macaque-derived tau GFP-Lyon ES cells underwent kisspeptin-specific neuronal differentiation.
Report a problemFND-2828889903

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

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