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Study · In vitro (cells) · 2017

3 results

[Peptide drug cortexin inhibits brain caspase-8].

Yakovlev AA, Lyzhin AA, Khaspekov LG, Guekht AB, Gulyaeva NV

Biomeditsinskaia khimiia1 Jan 2017Cited by 3 (Europe PMC)

PMID28251948 (opens in a new tab)DOI10.18097/pbmc2017630127 (opens in a new tab)PepBankPUB-28251948
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In neuronal cultures, Cortexin prevented damage in a model of glutamate-induced cell death.

    In plain wordsIn cells, Cortexin prevented neuronal damage in a model of glutamate-induced cell death.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseGlutamate-induced neuronal damage
    Study

    n: not reported in source

    Neuronal culture with glutamate-induced cell death
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both cortexin and its fraction prevented neuronal damage in a culture model of glutamate-induced cell death.
  2. 02LabIn vitro (cell-free)Activity measurement

    In brain protease assays, Cortexin effectively inhibited caspase-8.

    In plain wordsIn lab tests, Cortexin inhibited brain caspase-8.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseBrain caspase-8 inhibition
    Study

    n: not reported in source

    Brain protease assay
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cortexin effectively inhibited brain caspase-8,
  3. 03LabIn vitro (cell-free)Activity measurement

    In brain protease assays, Cortexin effects on caspase-1, -3, -9, cathepsin B and calpain were weaker or absent.

    In plain wordsIn lab tests, Cortexin inhibited other brain proteases less than caspase-8, or had no effect on them.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    MixedOther brain protease inhibition
    Study

    n: not reported in source

    Brain protease assay
    Comparator
    Caspase-8 inhibition
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cortexin effectively inhibited brain caspase-8, while its effects on caspase-1, -3, -9, cathepsin B and calpain were much less pronounced or absent.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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