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Study · Animal study (in vivo) · mouse · 2017

3 results

Adrenocorticotropic hormone protects learning and memory function in epileptic Kcna1-null mice.

Scantlebury MH, Chun KC, Ma SC, Rho JM, Kim DY

Neuroscience letters27 Feb 2017Cited by 12 (Europe PMC)

PMID28249786 (opens in a new tab)PMCIDPMC5774237 (opens in a new tab)DOI10.1016/j.neulet.2017.02.069 (opens in a new tab)PepBankPUB-28249786
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In epileptic Kcna1-null mice, Acthar Gel prevented impairment of high-frequency stimulation-evoked CA1 hippocampal long-term potentiation.

    In plain wordsIn mice with epilepsy, Acthar Gel prevented impairment of hippocampal long-term potentiation.

    Peptide
    ACTH (corticotropin)
    Outcome
    IncreaseCA1 long-term potentiation
    Study

    mousen: not reported in source

    Epileptic Kcna1-null mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    4 IU/kg four times daily (16 IU/kg/day) · intraperitoneal · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    We found that ACTH - administered in the form of Acthar Gel given i.p. four times daily at a dose of 4 IU/kg (16 IU/kg/day) for 7days - prevented impairment of long-term potentiation (LTP) evoked with high-frequency stimulation in CA1 hippocampus
    1 context sentence
    Summary · context
    We tested whether ACTH can ameliorate the intrinsic impairment of hippocampal-based learning and memory in epileptic Kcna1-null (KO) mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In epileptic Kcna1-null mice, Acthar Gel restored spatial learning and memory on the Barnes maze test.

    In plain wordsIn mice with epilepsy, Acthar Gel restored spatial learning and memory on the Barnes maze test.

    Peptide
    ACTH (corticotropin)
    Outcome
    IncreaseSpatial learning and memory
    Study

    mousen: not reported in source

    Epileptic Kcna1-null mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    4 IU/kg four times daily (16 IU/kg/day) · intraperitoneal · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    and also restored spatial learning and memory on the Barnes maze test.
    2 context sentences
    Summary · context
    ACTH - administered in the form of Acthar Gel given i.p. four times daily at a dose of 4 IU/kg (16 IU/kg/day) for 7days
    Summary · context
    We tested whether ACTH can ameliorate the intrinsic impairment of hippocampal-based learning and memory in epileptic Kcna1-null (KO) mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In epileptic Kcna1-null mice, Acthar Gel did not significantly affect spontaneous recurrent seizure frequency.

    In plain wordsIn mice with epilepsy, Acthar Gel did not significantly change spontaneous recurrent seizure frequency.

    Peptide
    ACTH (corticotropin)
    Outcome
    No significant changeSpontaneous recurrent seizure frequency
    Study

    mousen: not reported in source

    Epileptic Kcna1-null mice
    Outcome group
    Seizures · Nervous system and cognition
    Studied dose
    4 IU/kg four times daily (16 IU/kg/day) · intraperitoneal · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    However, with this treatment regimen, ACTH did not exert a significant effect on the frequency of spontaneous recurrent seizures.
    1 context sentence
    Summary · context
    We tested whether ACTH can ameliorate the intrinsic impairment of hippocampal-based learning and memory in epileptic Kcna1-null (KO) mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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