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Study · Animal study (in vivo) · rat · 2017

3 results

Hypermagnesemia disturbances in rats, NO-related: pentadecapeptide BPC 157 abrogates, L-NAME and L-arginine worsen.

Medvidovic-Grubisic M, Stambolija V, Kolenc D, Katancic J, Murselovic T, Plestina-Borjan I, Strbe S, Drmic D, Barisic I, Sindic A, Seiwerth S, Sikiric P

Inflammopharmacology16 Feb 2017Cited by 28 (Europe PMC)

PMID28210905 (opens in a new tab)DOI10.1007/s10787-017-0323-6 (opens in a new tab)PepBankPUB-28210905
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats given magnesium sulfate, BPC‑157 abrogated hypermagnesemia.

    In plain wordsIn rats given a high magnesium dose, BPC‑157 prevented the rise in blood magnesium.

    Peptide
    BPC-157
    Outcome
    DecreaseHypermagnesemia
    Study

    ratn: not reported in source

    magnesium sulfate toxicity
    Outcome group
    Adverse events · Whole body
    Studied dose
    10 µg/kg, 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 abrogated hypermagnesemia
    1 context sentence
    Summary · context
    Stable gastric pentadecapeptide BPC 157, administered before a high-dose magnesium injection in rats, might be a useful peptide therapy against magnesium toxicity and the magnesium-induced effect on cell depolarization.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats given magnesium sulfate, BPC‑157 counteracted all magnesium-induced disturbances, including those aggravated by L-NAME or L-arginine.

    In plain wordsIn rats given a high magnesium dose, BPC‑157 counteracted the harmful effects, including worsening by L-NAME or L-arginine.

    Peptide
    BPC-157
    Outcome
    DecreaseMagnesium-induced disturbances (muscle weakness, lesions, hyperkalaemia, serum enzymes)
    Study

    ratn: not reported in source

    magnesium sulfate toxicity
    Outcome group
    Adverse events · Whole body
    Studied dose
    10 µg/kg, 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    counteracted all of the magnesium-induced disturbances (including those aggravated by L-NAME or L-arginine).
    1 context sentence
    Summary · context
    Stable gastric pentadecapeptide BPC 157, administered before a high-dose magnesium injection in rats, might be a useful peptide therapy against magnesium toxicity and the magnesium-induced effect on cell depolarization.
  3. 03LabIn vitro (cells)Mechanism

    In HEK293 cells, depolarization due to increasing magnesium concentration was inhibited in the presence of BPC‑157.

    In plain wordsIn cells, BPC‑157 blocked the electrical change caused by higher magnesium levels.

    Peptide
    BPC-157
    Outcome
    DecreaseMagnesium-induced cell depolarization
    Study

    humann: not reported in source

    HEK293 cells
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    1 µMAs given in this study (human).

    Source sentences

    Summary
    Thus, cell depolarization due to increasing magnesium concentration was inhibited in the presence of BPC 157 (1 µM) in vitro.
    1 context sentence
    Summary · context
    In HEK293 cells, the increasing magnesium concentration from 1 to 5 mM could depolarize the cells at 1.75 ± 0.44 mV.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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