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Study · In vitro (cells) · mouse and rat · 2017

14 results

Kisspeptin-10 inhibits proliferation and regulates lipolysis and lipogenesis processes in 3T3-L1 cells and isolated rat adipocytes.

Pruszyńska-Oszmałek E, Kołodziejski PA, Sassek M, Sliwowska JH

Endocrine13 Feb 2017Cited by 38 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In 3T3-L1 cells, kisspeptin‑10 inhibited cell proliferation.

    In plain wordsIn lab cells, kisspeptin‑10 slowed the growth of mouse fat-cell precursors.

    Outcome
    DecreaseCell proliferation
    Study

    mousen: not reported in source

    3T3-L1 cells
    Outcome group
    Cell proliferation and differentiation · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    inhibited cell proliferation, viability and adipogenesis in 3T3-L1
  2. 02LabIn vitro (cells)Efficacy outcome

    In 3T3-L1 cells, kisspeptin‑10 inhibited cell viability.

    In plain wordsIn lab cells, kisspeptin‑10 lowered the viability of mouse fat-cell precursors.

    Outcome
    DecreaseCell viability
    Study

    mousen: not reported in source

    3T3-L1 cells
    Outcome group
    Cell proliferation and differentiation · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    inhibited cell proliferation, viability and adipogenesis in 3T3-L1
  3. 03LabIn vitro (cells)Efficacy outcome

    In 3T3-L1 cells, kisspeptin‑10 inhibited adipogenesis.

    In plain wordsIn lab cells, kisspeptin‑10 reduced the development of mouse fat cells.

    Outcome
    DecreaseAdipogenesis
    Study

    mousen: not reported in source

    3T3-L1 cells
    Outcome group
    Fat metabolism and adipogenesis · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    inhibited cell proliferation, viability and adipogenesis in 3T3-L1
  4. 04LabIn vitro (cells)Mechanism

    In 3T3-L1 cells, kisspeptin‑10 decreased expression of PPAR-γ, which is involved in differentiation and adipogenesis.

    In plain wordsIn lab cells, kisspeptin‑10 lowered the activity of PPAR-γ, a gene that drives fat-cell development.

    Outcome
    DecreasePPAR-γ expression
    Study

    mousen: not reported in source

    3T3-L1 cells
    Outcome group
    Fat metabolism and adipogenesis · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    decreased expression of PPAR-γ and CEBPβ-genes
  5. 05LabIn vitro (cells)Mechanism

    In 3T3-L1 cells, kisspeptin‑10 decreased expression of CEBPβ, which is involved in differentiation and adipogenesis.

    In plain wordsIn lab cells, kisspeptin‑10 lowered the activity of CEBPβ, a gene that drives fat-cell development.

    Outcome
    DecreaseCEBPβ expression
    Study

    mousen: not reported in source

    3T3-L1 cells
    Outcome group
    Fat metabolism and adipogenesis · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    decreased expression of PPAR-γ and CEBPβ-genes
  6. 06LabIn vitro (cells)Efficacy outcome

    In 3T3-L1 cells, kisspeptin‑10 increased lipolysis.

    In plain wordsIn lab cells, kisspeptin‑10 increased the breakdown of fat in mouse fat cells.

    Outcome
    IncreaseLipolysis in 3T3-L1 cells
    Study

    mousen: not reported in source

    3T3-L1 cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased lipolysis in 3T3-L1 cells and rat adipocytes by enhancing expression of periliphin and hormone-sensitive lipase
  7. 07LabIn vitro (cells)Efficacy outcome

    In isolated rat adipocytes, kisspeptin‑10 increased lipolysis.

    In plain wordsIn lab-isolated rat fat cells, kisspeptin‑10 increased the breakdown of fat.

    Outcome
    IncreaseLipolysis in rat adipocytes
    Study

    ratn: not reported in source

    Isolated rat adipocytes
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased lipolysis in 3T3-L1 cells and rat adipocytes by enhancing expression of periliphin and hormone-sensitive lipase
  8. 08LabIn vitro (cells)Mechanism

    In 3T3-L1 cells and rat adipocytes, kisspeptin‑10 increased lipolysis by enhancing expression of perilipin.

    In plain wordsIn lab fat cells, kisspeptin‑10 raised the activity of perilipin, a gene linked to fat breakdown.

    Outcome
    IncreasePerilipin expression
    Study

    mousen: not reported in source

    3T3-L1 cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased lipolysis in 3T3-L1 cells and rat adipocytes by enhancing expression of periliphin and hormone-sensitive lipase
  9. 09LabIn vitro (cells)Mechanism

    In 3T3-L1 cells and rat adipocytes, kisspeptin‑10 increased lipolysis by enhancing expression of hormone-sensitive lipase.

    In plain wordsIn lab fat cells, kisspeptin‑10 raised the activity of hormone-sensitive lipase, a fat-breaking enzyme.

    Outcome
    IncreaseHormone-sensitive lipase expression
    Study

    mousen: not reported in source

    3T3-L1 cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased lipolysis in 3T3-L1 cells and rat adipocytes by enhancing expression of periliphin and hormone-sensitive lipase
  10. 10LabIn vitro (cells)Efficacy outcome

    Kisspeptin‑10 modulated glucose uptake in 3T3-L1 cells and rat primary adipocytes; the direction is not given in the abstract.

    In plain wordsIn lab fat cells, kisspeptin‑10 changed glucose uptake, but the abstract does not say in which direction.

    Outcome
    Direction not reportedGlucose uptake
    Study

    mousen: not reported in source

    3T3-L1 cells
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    modulated glucose uptake and lipogenesis
  11. 11LabIn vitro (cells)Efficacy outcome

    Kisspeptin‑10 modulated lipogenesis in 3T3-L1 cells and rat primary adipocytes; the direction is not given in the abstract.

    In plain wordsIn lab fat cells, kisspeptin‑10 changed fat synthesis, but the abstract does not say in which direction.

    Outcome
    Direction not reportedLipogenesis
    Study

    mousen: not reported in source

    3T3-L1 cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    modulated glucose uptake and lipogenesis
  12. 12LabIn vitro (cells)Efficacy outcome

    In rat adipocytes, kisspeptin‑10 stimulated leptin secretion.

    In plain wordsIn lab-isolated rat fat cells, kisspeptin‑10 raised leptin release.

    Outcome
    IncreaseLeptin secretion
    Study

    ratn: not reported in source

    Isolated rat adipocytes
    Outcome group
    Adipokines · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    stimulated leptin and decreased adiponectin secretion from rat adipocytes.
  13. 13LabIn vitro (cells)Efficacy outcome

    In rat adipocytes, kisspeptin‑10 decreased adiponectin secretion.

    In plain wordsIn lab-isolated rat fat cells, kisspeptin‑10 lowered adiponectin release.

    Outcome
    DecreaseAdiponectin secretion
    Study

    ratn: not reported in source

    Isolated rat adipocytes
    Outcome group
    Adipokines · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    stimulated leptin and decreased adiponectin secretion from rat adipocytes.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 14LabEndogenous levelIn vitro (cells)Other

    KISS1 and GPR54 were expressed in mouse 3T3-L1 cells and in isolated rat adipocytes.

    In plain wordsMouse fat-cell lines and rat fat cells make the body's own kisspeptin and its receptor.

    Outcome
    Not applicableKISS1 and GPR54 expression in adipose cells
    Study

    mouse and ratn: not reported in source

    3T3-L1 cells and isolated rat adipocytes
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    (1) KISS1 and GPR54 were expressed in mouse 3T3-L1 cells and isolated rat adipocytes;

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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