Skip to content

Study · Not a test of the peptide alone · 2017

10 results

Recombinant adeno-associated virus carrying thymosin β4 suppresses experimental colitis in mice.

Zheng XY, Lv YF, Li S, Li Q, Zhang QN, Zhang XT, Hao ZM

World journal of gastroenterology1 Jan 2017Cited by 28 (Europe PMC)

PMID28127198 (opens in a new tab)PMCIDPMC5236504 (opens in a new tab)DOI10.3748/wjg.v23.i2.242 (opens in a new tab)PepBankPUB-28127198
Read at sourcePubMedAsk about this study
Jump to 10 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study10

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone10

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Pharmacokinetics

    In mice, intracolonic AAV-Tβ4 led to strong expression of Tβ4 in the colon.

    In plain wordsIn mice, a virus that carries the Tβ4 gene put into the colon led to strong Tβ4 production in the colon.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTβ4 expression in mouse colon
    Study

    mousen: not reported in source

    DSS and TNBS colitis models
    Outcome group
    Pharmacokinetics · Gastrointestinal

    Source sentences

    Summary
    Recombinant AAVs efficiently delivered LacZ and Tβ4 into the colonic tissues of the mice, and AAV-Tβ4 led to a strong expression of Tβ4 in mouse colons.
    2 context sentences
    Summary · context
    AAV-Tβ4 was prepared and intracolonically used to mediate the secretory expression of Tβ4 in mouse colons.
    Summary · context
    Dextran sulfate sodium (DSS) was applied to induce the murine ulcerative colitis, and 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used to establish a mouse colitis model resembling Crohn's disease.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In DSS and TNBS colitis in mice, AAV-Tβ4 attenuated colon injuries.

    In plain wordsIn mice with chemically induced colitis, a virus that carries the Tβ4 gene reduced colon injury.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseColon injury
    Study

    mousen: not reported in source

    DSS and TNBS colitis models
    Outcome group
    Gastrointestinal protection · Gastrointestinal

    Source sentences

    Summary
    In both the DSS and TNBS colitis models, AAV-Tβ4-treated mice displayed distinctly attenuated colon injuries and reduced apoptosis rate of colonic mucosal epithelia.
    2 context sentences
    Summary · context
    AAV-Tβ4 was prepared and intracolonically used to mediate the secretory expression of Tβ4 in mouse colons.
    Summary · context
    Dextran sulfate sodium (DSS) was applied to induce the murine ulcerative colitis, and 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used to establish a mouse colitis model resembling Crohn's disease.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In DSS and TNBS colitis in mice, AAV-Tβ4 reduced the apoptosis rate of colonic mucosal epithelia.

    In plain wordsIn mice with chemically induced colitis, a virus that carries the Tβ4 gene reduced cell death in the colon lining.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseApoptosis of colonic mucosal epithelia
    Study

    mousen: not reported in source

    DSS and TNBS colitis models
    Outcome group
    Gastrointestinal protection · Gastrointestinal

    Source sentences

    Summary
    In both the DSS and TNBS colitis models, AAV-Tβ4-treated mice displayed distinctly attenuated colon injuries and reduced apoptosis rate of colonic mucosal epithelia.
    2 context sentences
    Summary · context
    AAV-Tβ4 was prepared and intracolonically used to mediate the secretory expression of Tβ4 in mouse colons.
    Summary · context
    Dextran sulfate sodium (DSS) was applied to induce the murine ulcerative colitis, and 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used to establish a mouse colitis model resembling Crohn's disease.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In mice with colitis, AAV-Tβ4 reduced inflammatory cell infiltration and MPO activity in the inflamed colon.

    In plain wordsIn mice with colitis, a virus that carries the Tβ4 gene reduced immune cell buildup and MPO activity in the inflamed colon.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseInflammatory cell infiltration and myeloperoxidase activity
    Study

    mousen: not reported in source

    DSS and TNBS colitis models
    Outcome group
    Inflammation markers · Gastrointestinal

    Source sentences

    Summary
    AAV-Tβ4 significantly reduced inflammatory cell infiltrations and relieved oxidative stress in the inflamed colons of the mice, as evidenced by decreases in MPO activity and MDA content and increases in SOD activity.
    2 context sentences
    Summary · context
    AAV-Tβ4 was prepared and intracolonically used to mediate the secretory expression of Tβ4 in mouse colons.
    Summary · context
    Dextran sulfate sodium (DSS) was applied to induce the murine ulcerative colitis, and 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used to establish a mouse colitis model resembling Crohn's disease.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  5. 05AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In mice with colitis, AAV-Tβ4 decreased MDA content in the inflamed colon.

    In plain wordsIn mice with colitis, a virus that carries the Tβ4 gene lowered MDA, a marker of oxidative damage, in the inflamed colon.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseMalondialdehyde content
    Study

    mousen: not reported in source

    DSS and TNBS colitis models
    Outcome group
    Oxidative stress · Gastrointestinal

    Source sentences

    Summary
    AAV-Tβ4 significantly reduced inflammatory cell infiltrations and relieved oxidative stress in the inflamed colons of the mice, as evidenced by decreases in MPO activity and MDA content and increases in SOD activity.
    2 context sentences
    Summary · context
    AAV-Tβ4 was prepared and intracolonically used to mediate the secretory expression of Tβ4 in mouse colons.
    Summary · context
    Dextran sulfate sodium (DSS) was applied to induce the murine ulcerative colitis, and 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used to establish a mouse colitis model resembling Crohn's disease.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  6. 06AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In mice with colitis, AAV-Tβ4 increased SOD activity in the inflamed colon.

    In plain wordsIn mice with colitis, a virus that carries the Tβ4 gene raised SOD, an antioxidant enzyme, in the inflamed colon.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSuperoxide dismutase activity
    Study

    mousen: not reported in source

    DSS and TNBS colitis models
    Outcome group
    Oxidative stress · Gastrointestinal

    Source sentences

    Summary
    AAV-Tβ4 significantly reduced inflammatory cell infiltrations and relieved oxidative stress in the inflamed colons of the mice, as evidenced by decreases in MPO activity and MDA content and increases in SOD activity.
    2 context sentences
    Summary · context
    AAV-Tβ4 was prepared and intracolonically used to mediate the secretory expression of Tβ4 in mouse colons.
    Summary · context
    Dextran sulfate sodium (DSS) was applied to induce the murine ulcerative colitis, and 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used to establish a mouse colitis model resembling Crohn's disease.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  7. 07AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In DSS and TNBS colitis in mice, AAV-Tβ4 modulated colonic TNF-α levels; the abstract gives no direction.

    In plain wordsIn mice with chemically induced colitis, a virus that carries the Tβ4 gene changed colon TNF-α levels. The direction is not stated.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedColonic TNF-α level
    Study

    mousen: not reported in source

    DSS and TNBS colitis models
    Outcome group
    Inflammation markers · Gastrointestinal

    Source sentences

    Summary
    AAV-Tβ4 also modulated colonic TNF-α, IL-1β and IL-10 levels and suppressed the compensatory proliferation of colonic epithelial cells in DSS- and TNBS-treated mice.
    2 context sentences
    Summary · context
    AAV-Tβ4 was prepared and intracolonically used to mediate the secretory expression of Tβ4 in mouse colons.
    Summary · context
    Dextran sulfate sodium (DSS) was applied to induce the murine ulcerative colitis, and 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used to establish a mouse colitis model resembling Crohn's disease.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  8. 08AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In DSS and TNBS colitis in mice, AAV-Tβ4 modulated colonic IL-1β levels; the abstract gives no direction.

    In plain wordsIn mice with chemically induced colitis, a virus that carries the Tβ4 gene changed colon IL-1β levels. The direction is not stated.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedColonic IL-1β level
    Study

    mousen: not reported in source

    DSS and TNBS colitis models
    Outcome group
    Inflammation markers · Gastrointestinal

    Source sentences

    Summary
    AAV-Tβ4 also modulated colonic TNF-α, IL-1β and IL-10 levels and suppressed the compensatory proliferation of colonic epithelial cells in DSS- and TNBS-treated mice.
    2 context sentences
    Summary · context
    AAV-Tβ4 was prepared and intracolonically used to mediate the secretory expression of Tβ4 in mouse colons.
    Summary · context
    Dextran sulfate sodium (DSS) was applied to induce the murine ulcerative colitis, and 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used to establish a mouse colitis model resembling Crohn's disease.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  9. 09AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In DSS and TNBS colitis in mice, AAV-Tβ4 modulated colonic IL-10 levels; the abstract gives no direction.

    In plain wordsIn mice with chemically induced colitis, a virus that carries the Tβ4 gene changed colon IL-10 levels. The direction is not stated.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedColonic IL-10 level
    Study

    mousen: not reported in source

    DSS and TNBS colitis models
    Outcome group
    Inflammation markers · Gastrointestinal

    Source sentences

    Summary
    AAV-Tβ4 also modulated colonic TNF-α, IL-1β and IL-10 levels and suppressed the compensatory proliferation of colonic epithelial cells in DSS- and TNBS-treated mice.
    2 context sentences
    Summary · context
    AAV-Tβ4 was prepared and intracolonically used to mediate the secretory expression of Tβ4 in mouse colons.
    Summary · context
    Dextran sulfate sodium (DSS) was applied to induce the murine ulcerative colitis, and 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used to establish a mouse colitis model resembling Crohn's disease.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  10. 10AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In DSS and TNBS colitis in mice, AAV-Tβ4 suppressed compensatory proliferation of colonic epithelial cells.

    In plain wordsIn mice with chemically induced colitis, a virus that carries the Tβ4 gene reduced the extra growth of colon lining cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCompensatory proliferation of colonic epithelial cells
    Study

    mousen: not reported in source

    DSS and TNBS colitis models
    Outcome group
    Gastrointestinal protection · Gastrointestinal

    Source sentences

    Summary
    AAV-Tβ4 also modulated colonic TNF-α, IL-1β and IL-10 levels and suppressed the compensatory proliferation of colonic epithelial cells in DSS- and TNBS-treated mice.
    2 context sentences
    Summary · context
    AAV-Tβ4 was prepared and intracolonically used to mediate the secretory expression of Tβ4 in mouse colons.
    Summary · context
    Dextran sulfate sodium (DSS) was applied to induce the murine ulcerative colitis, and 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used to establish a mouse colitis model resembling Crohn's disease.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.