Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium.

Hinkel R, Howe A, Renner S, Ng J, Lee S, Klett K, Kaczmarek V, Moretti A, Laugwitz KL, Skroblin P, Mayr M, Milting H and 4 more

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Dendorfer A, Reichart B, Wolf E, Kupatt C

Journal of the American College of Cardiology1 Jan 2017Cited by 141 (Europe PMC)

PMID28081822DOI10.1016/j.jacc.2016.10.058PepBankPUB-28081822

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In diabetic pigs with chronic ischemia, rAAV.Tβ4 enhanced capillary density, less efficiently than in wild-type hearts.
In plain wordsIn diabetic pigs with poor heart blood flow, a virus that raises Tβ4 gene activity increased tiny vessel density, but less than in normal pigs.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCapillary density in diabetic hearts
Study
pign: not reported in source
diabetic (db) and wild-type pigs with chronic myocardial ischemia
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
Treatment with rAAV.Tβ4 enhanced capillary density and maturation in db hearts less efficiently than in wt hearts, similar to collateral growth
2 context sentences(design, population, supporting numbers)
Summary · context
Diabetic (db) and wild-type (wt) pigs were used to analyze myocardial vascularization and function.
Summary · context
Chronic ischemia was induced percutaneously (day 0) in the circumflex artery.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2808182201
02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In diabetic pigs with chronic ischemia, rAAV.Tβ4 enhanced capillary maturation, less efficiently than in wild-type hearts.
In plain wordsIn diabetic pigs with poor heart blood flow, a virus that raises Tβ4 gene activity improved blood vessel maturation, but less than in normal pigs.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCapillary maturation in diabetic hearts
Study
pign: not reported in source
diabetic (db) and wild-type pigs with chronic myocardial ischemia
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
Treatment with rAAV.Tβ4 enhanced capillary density and maturation in db hearts less efficiently than in wt hearts, similar to collateral growth
2 context sentences(design, population, supporting numbers)
Summary · context
Diabetic (db) and wild-type (wt) pigs were used to analyze myocardial vascularization and function.
Summary · context
Chronic ischemia was induced percutaneously (day 0) in the circumflex artery.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2808182202
03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In diabetic pigs with chronic ischemia, rAAV.Tβ4 increased collateral growth less efficiently than in wild-type hearts.
In plain wordsIn diabetic pigs with poor heart blood flow, a virus that raises Tβ4 gene activity increased bypass vessel growth, but less than in normal pigs.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCollateral growth in diabetic hearts
Study
pign: not reported in source
diabetic (db) and wild-type pigs with chronic myocardial ischemia
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
Treatment with rAAV.Tβ4 enhanced capillary density and maturation in db hearts less efficiently than in wt hearts, similar to collateral growth
2 context sentences(design, population, supporting numbers)
Summary · context
Diabetic (db) and wild-type (wt) pigs were used to analyze myocardial vascularization and function.
Summary · context
Chronic ischemia was induced percutaneously (day 0) in the circumflex artery.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2808182203
04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In diabetic pigs with chronic ischemia, rAAV.Tβ4 improved ejection fraction (34.5%), less than in wild-type hearts (44.8%).
In plain wordsIn diabetic pigs with poor heart blood flow, a virus that raises Tβ4 gene activity improved ejection fraction to 34.5%, versus 44.8% in normal pigs.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseEjection fraction in diabetic hearts after rAAV.Tβ4
Study
pign: not reported in source
diabetic (db) and wild-type pigs with chronic myocardial ischemia
Outcome group
Heart function · Cardiovascular
Measurements
Ejection fraction
34.5%
db hearts, rAAV.Tβ4
Source sentences
Summary
As a result, rAAV.Tβ4 but not rAAV.VEGF-A improved EF in db hearts (34.5 ± 1.4%), but less so than in wt hearts (44.8 ± 1.5%).
2 context sentences(design, population, supporting numbers)
Summary · context
Diabetic (db) and wild-type (wt) pigs were used to analyze myocardial vascularization and function.
Summary · context
Chronic ischemia was induced percutaneously (day 0) in the circumflex artery.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2808182204
05AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In wild-type pigs with chronic ischemia, rAAV.Tβ4 treatment gave an ejection fraction of 44.8%.
In plain wordsIn normal pigs with poor heart blood flow, a virus that raises Tβ4 gene activity gave an ejection fraction of 44.8%.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseEjection fraction in wild-type hearts after rAAV.Tβ4
Study
pign: not reported in source
wild-type pigs with chronic myocardial ischemia
Outcome group
Heart function · Cardiovascular
Measurements
Ejection fraction
44.8%
wt hearts, rAAV.Tβ4
Source sentences
Summary
As a result, rAAV.Tβ4 but not rAAV.VEGF-A improved EF in db hearts (34.5 ± 1.4%), but less so than in wt hearts (44.8 ± 1.5%).
2 context sentences(design, population, supporting numbers)
Summary · context
Diabetic (db) and wild-type (wt) pigs were used to analyze myocardial vascularization and function.
Summary · context
Chronic ischemia was induced percutaneously (day 0) in the circumflex artery.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2808182205

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

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