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Study · Animal study (in vivo) · mouse · 2017

3 results

SS31 ameliorates age-related activation of NF-κB signaling in senile mice model, SAMP8.

Hao ZH, Huang Y, Wang MR, Huo TT, Jia Q, Feng RF, Fan P, Wang JH

Oncotarget1 Jan 2017Cited by 10 (Europe PMC)

PMID28030844 (opens in a new tab)PMCIDPMC5356771 (opens in a new tab)DOI10.18632/oncotarget.14077 (opens in a new tab)PepBankPUB-28030844
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Summary

Aging has been attributed to oxidative stress and inflammatory response, in which NF-κB and Nrf2-ARE signaling pathways play significant roles. Senescence accelerated mouse prone 8 (SAMP8) is generally used an animal model for aging studies. Here, we investigated the NF-κB and Nrf2-ARE signaling pathways in SAMP8 brains at different ages and their responses to SS31 peptide treatment. Thirty six SAMP8 mice were separated into aging groups and SS31-treatment groups. The hippocampus from each mouse was dissected for RNA and protein extraction. Cytokines and ROS levels were measured using ELISA and standardised method. Gene expressions of NF-κB, Nrf2 and HO-1 were measured by RT-qPCR. Total protein amount of NF-κB and HO-1, as well as the concentrations of nuclear and cytoplasmic Nrf2 were measured using Western blots. Our data showed that aging could activate both NF-κB and Nrf2-ARE signaling pathways, which could be suppressed and activated by SS31 treatment respectively. Regression analysis revealed that NF-κB gene expression was the most important parameter predicting aging process and SS31 treatment effects in SAMP8. Our findings suggested that SS31 treatment may modulate the inflammatory and oxidative stress status of the aged brains and exert protective effects during brain aging.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In senescence-accelerated SAMP8 mice, SS31 treatment suppressed the age-related activation of the NF-κB signaling pathway in the brain.

    In plain wordsIn mice that age fast, SS31 treatment lowered the age-related activation of an inflammation pathway (NF-κB) in the brain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNF-κB signaling pathway activity
    Study

    mousen = 36

    SAMP8 senescence-accelerated mice, hippocampus
    Comparator
    Untreated SAMP8 mice
    Outcome group
    Inflammation markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our data showed that aging could activate both NF-κB and Nrf2-ARE signaling pathways, which could be suppressed and activated by SS31 treatment respectively.
    1 context sentence
    Summary · context
    Thirty six SAMP8 mice were separated into aging groups and SS31-treatment groups.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In senescence-accelerated SAMP8 mice, SS31 treatment activated the Nrf2-ARE antioxidant signaling pathway in the brain.

    In plain wordsIn mice that age fast, SS31 treatment switched on an antioxidant defence pathway (Nrf2-ARE) in the brain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseNrf2-ARE signaling pathway activity
    Study

    mousen = 36

    SAMP8 senescence-accelerated mice, hippocampus
    Comparator
    Untreated SAMP8 mice
    Outcome group
    Inflammation markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our data showed that aging could activate both NF-κB and Nrf2-ARE signaling pathways, which could be suppressed and activated by SS31 treatment respectively.
    1 context sentence
    Summary · context
    Thirty six SAMP8 mice were separated into aging groups and SS31-treatment groups.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In SAMP8 mice, regression analysis found NF-κB gene expression to be the most important parameter that predicted the aging process and the effects of SS31 treatment.

    In plain wordsIn mice that age fast, NF-κB gene activity best predicted both aging and the effects of SS31 treatment.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Not applicableNF-κB gene expression as predictor of aging and SS31 effects
    Study

    mousen = 36

    SAMP8 senescence-accelerated mice, hippocampus
    Comparator
    Untreated SAMP8 mice
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Regression analysis revealed that NF-κB gene expression was the most important parameter predicting aging process and SS31 treatment effects in SAMP8.
    1 context sentence
    Summary · context
    Thirty six SAMP8 mice were separated into aging groups and SS31-treatment groups.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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