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Study · Not a test of the peptide alone · 2017

3 results

Thymosin β4 overexpression regulates neuron production and spatial distribution in the developing avian optic tectum.

Lever M, Theiss C, Morosan-Puopolo G, Brand-Saberi B

Histochemistry and cell biology10 Dec 2016Cited by 11 (Europe PMC)

PMID27942867 (opens in a new tab)DOI10.1007/s00418-016-1529-1 (opens in a new tab)PepBankPUB-27942867
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In embryonic chicken, Tβ4 overexpression led to a tangential expansion of the treated optic tectum hemisphere.

    In plain wordsIn chicken embryos, raising Tβ4 gene activity made the treated half of the optic tectum (a brain region) expand sideways.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTangential expansion of the treated optic tectum hemisphere
    Study

    chickenn: not reported in source

    embryonic chicken optic tectum
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Our experiments now demonstrate more clearly that the overexpression of Tβ4 leads to a tangential expansion of the treated OT-hemisphere and that, under these circumstances, overall density of tectal and in particular of postmitotic neuronal cells is increased.
    1 context sentence
    Summary · context
    In the present study, using in ovo electroporation, we carried out a quantification of the effects of the Tβ4-overexpression on the developing chicken OT between E4 and E6 at the hemisphere as well as cellular level.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In embryonic chicken, Tβ4 overexpression increased the overall density of tectal cells.

    In plain wordsIn chicken embryos, raising Tβ4 gene activity increased the overall density of cells in the optic tectum.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseOverall density of tectal cells
    Study

    chickenn: not reported in source

    embryonic chicken optic tectum
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Our experiments now demonstrate more clearly that the overexpression of Tβ4 leads to a tangential expansion of the treated OT-hemisphere and that, under these circumstances, overall density of tectal and in particular of postmitotic neuronal cells is increased.
    1 context sentence
    Summary · context
    In the present study, using in ovo electroporation, we carried out a quantification of the effects of the Tβ4-overexpression on the developing chicken OT between E4 and E6 at the hemisphere as well as cellular level.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In embryonic chicken, Tβ4 overexpression increased the density of postmitotic neuronal cells in the optic tectum.

    In plain wordsIn chicken embryos, raising Tβ4 gene activity increased the density of nerve cells that had stopped dividing in the optic tectum.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseDensity of postmitotic neuronal cells
    Study

    chickenn: not reported in source

    embryonic chicken optic tectum
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Our experiments now demonstrate more clearly that the overexpression of Tβ4 leads to a tangential expansion of the treated OT-hemisphere and that, under these circumstances, overall density of tectal and in particular of postmitotic neuronal cells is increased.
    1 context sentence
    Summary · context
    In the present study, using in ovo electroporation, we carried out a quantification of the effects of the Tβ4-overexpression on the developing chicken OT between E4 and E6 at the hemisphere as well as cellular level.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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