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Study · Animal study (in vivo) · rat · 2016

5 results

Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME.

Djakovic Z, Djakovic I, Cesarec V, Madzarac G, Becejac T, Zukanovic G, Drmic D, Batelja L, Zenko Sever A, Kolenc D, Pajtak A, Knez N and 5 more

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Japjec M, Luetic K, Stancic-Rokotov D, Seiwerth S, Sikiric P

World journal of gastroenterology1 Nov 2016Cited by 20 (Europe PMC)

PMID27895400 (opens in a new tab)PMCIDPMC5107594 (opens in a new tab)DOI10.3748/wjg.v22.i41.9127 (opens in a new tab)PepBankPUB-27895400
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with esophagogastric anastomosis, BPC‑157 in all regimens fully counteracted the perilous disease course.

    In plain wordsIn rats with a join between esophagus and stomach, BPC‑157 fully counteracted the dangerous disease course.

    Peptide
    BPC-157
    Outcome
    DecreaseDisease course after esophagogastric anastomosis
    Study

    ratn: not reported in source

    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg and 10 ng/kg · intraperitoneal or drinking water · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 (all regimens) fully counteracted the perilous disease course from the very beginning (i.e., with the BPC 157 bath, blood vessels remained present at the gastric surface after anastomosis creation) and eliminated mortality.
    1 context sentence
    Summary · context
    In the 4 d after esophagogastric anastomosis creation, rats received medication (/kg intraperitoneally once daily: BPC 157 (10 μg, 10 ng), L-NAME (5 mg), or L-arginine (100 mg) alone and/or combined or BPC 157 (10 μg, 10 ng) in drinking water).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with esophagogastric anastomosis, the BPC‑157 bath kept blood vessels present at the gastric surface after anastomosis creation.

    In plain wordsIn rats with a join between esophagus and stomach, BPC‑157 kept blood vessels present on the stomach surface.

    Peptide
    BPC-157
    Outcome
    DecreaseBlood vessel disappearance at the stomach surface
    Study

    ratn: not reported in source

    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg and 10 ng/kg · intraperitoneal or drinking water · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 (all regimens) fully counteracted the perilous disease course from the very beginning (i.e., with the BPC 157 bath, blood vessels remained present at the gastric surface after anastomosis creation)
    1 context sentence
    Summary · context
    In the 4 d after esophagogastric anastomosis creation, rats received medication (/kg intraperitoneally once daily: BPC 157 (10 μg, 10 ng), L-NAME (5 mg), or L-arginine (100 mg) alone and/or combined or BPC 157 (10 μg, 10 ng) in drinking water).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with esophagogastric anastomosis, BPC‑157 eliminated mortality.

    In plain wordsIn rats with a join between esophagus and stomach, BPC‑157 eliminated deaths.

    Peptide
    BPC-157
    Outcome
    DecreaseMortality
    Study

    ratn: not reported in source

    Outcome group
    Mortality · Gastrointestinal
    Studied dose
    10 µg/kg and 10 ng/kg · intraperitoneal or drinking water · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    and eliminated mortality.
    1 context sentence
    Summary · context
    In the 4 d after esophagogastric anastomosis creation, rats received medication (/kg intraperitoneally once daily: BPC 157 (10 μg, 10 ng), L-NAME (5 mg), or L-arginine (100 mg) alone and/or combined or BPC 157 (10 μg, 10 ng) in drinking water).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with esophagogastric anastomosis, BPC‑157 combined with L-NAME nullified the effect of L-NAME that otherwise intensified the course.

    In plain wordsIn rats with a join between esophagus and stomach, BPC‑157 cancelled the worsening effect of L-NAME.

    Peptide
    BPC-157
    Outcome
    DecreaseL-NAME-intensified course
    Study

    ratn: not reported in source

    Comparator
    L-NAME alone
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg and 10 ng/kg · intraperitoneal or drinking water · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    Additionally, BPC 157 treatment in combination with L-NAME nullified any effect of L-NAME that otherwise intensified the regular course.
    1 context sentence
    Summary · context
    In the 4 d after esophagogastric anastomosis creation, rats received medication (/kg intraperitoneally once daily: BPC 157 (10 μg, 10 ng), L-NAME (5 mg), or L-arginine (100 mg) alone and/or combined or BPC 157 (10 μg, 10 ng) in drinking water).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with esophagogastric anastomosis, adding BPC‑157 to L-NAME plus L-arginine gave a marked beneficial effect.

    In plain wordsIn rats with a join between esophagus and stomach, adding BPC‑157 to L-NAME plus L-arginine had a marked beneficial effect.

    Peptide
    BPC-157
    Outcome
    Not applicableCourse with L-NAME plus L-arginine plus BPC 157
    Study

    ratn: not reported in source

    Comparator
    L-NAME plus L-arginine
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg and 10 ng/kg · intraperitoneal or drinking water · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    with the addition of BPC 157 (L-NAME + L-arginine + BPC 157), there was a marked beneficial effect.
    1 context sentence
    Summary · context
    In the 4 d after esophagogastric anastomosis creation, rats received medication (/kg intraperitoneally once daily: BPC 157 (10 μg, 10 ng), L-NAME (5 mg), or L-arginine (100 mg) alone and/or combined or BPC 157 (10 μg, 10 ng) in drinking water).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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