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Study · Animal study (in vivo) · cattle · 2017

2 results

Oxyntomodulin analog and exendin-4 derivative lower plasma glucose in cattle.

ThanThan S, Asada Y, Saito T, Ochiiwa K, Zhao H, Naing SW, Kuwayama H

Domestic animal endocrinology2 Nov 2016Cited by 3 (Europe PMC)

PMID27888738 (opens in a new tab)DOI10.1016/j.domaniend.2016.10.005 (opens in a new tab)PepBankPUB-27888738
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Holstein steers, Ex-4 had more potent insulinotropic effects than [Gly2, Glu3]-glucandin.

    In plain wordsIn cattle, Ex-4 stimulated insulin more potently than [Gly2, Glu3]-glucandin.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseInsulinotropic effect
    Study

    cattlen: not reported in source

    Holstein steers
    Comparator
    [Gly2, Glu3]-glucandin
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0.3 μg/kg BW · injectionAs given in this study (cattle).

    Source sentences

    Summary
    Results showed that the insulinotropic and glucose-lowering effects of [Gly2, Glu3]-glucandin were not as potent as for Ex-4 and GLP-1
    2 context sentences
    Summary · context
    Experiment 2 was carried out to better understand the glucose-lowering potency of [Gly2, Glu3]-glucandin, in comparison with Ex-4 and glucagon-like peptide-1 (GLP-1), using 4.5-mo-old Holstein steers.
    Summary · context
    Ex-4 and GLP-1 were injected at dose rates of 0.3 μg/kg BW.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Holstein steers, Ex-4 had more potent glucose-lowering effects than [Gly2, Glu3]-glucandin.

    In plain wordsIn cattle, Ex-4 lowered glucose more potently than [Gly2, Glu3]-glucandin.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseGlucose lowering
    Study

    cattlen: not reported in source

    Holstein steers
    Comparator
    [Gly2, Glu3]-glucandin
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0.3 μg/kg BW · injectionAs given in this study (cattle).

    Source sentences

    Summary
    Results showed that the insulinotropic and glucose-lowering effects of [Gly2, Glu3]-glucandin were not as potent as for Ex-4 and GLP-1
    2 context sentences
    Summary · context
    Experiment 2 was carried out to better understand the glucose-lowering potency of [Gly2, Glu3]-glucandin, in comparison with Ex-4 and glucagon-like peptide-1 (GLP-1), using 4.5-mo-old Holstein steers.
    Summary · context
    Ex-4 and GLP-1 were injected at dose rates of 0.3 μg/kg BW.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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