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Study · Animal study (in vivo) · rabbit · 2016

10 results

Efficacy of Cortexin and Methylprednisolone on Traumatic Facial Nerve Paralysis.

Tunçcan T, Yalçın Ş, Demir CF, Akın MM, Karlıdağ T, Keleş E, Kaygusuz İ

The journal of international advanced otology7 Nov 2016Cited by 2 (Europe PMC)

PMID27819650 (opens in a new tab)DOI10.5152/iao.2016.1166 (opens in a new tab)PepBankPUB-27819650
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with facial nerve trauma, cortexin differed significantly from saline across the reported nerve histology measures.

    In plain wordsIn rabbits, cortexin differed from saline on the reported nerve tissue measures.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Direction not reportedHistological nerve changes
    Study

    rabbitn: not reported in source

    Traumatic facial nerve paralysis
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    3 mg/day · intramuscular · 10 daysAs given in this study (rabbit).

    Source sentences

    Summary
    There was a significant difference between the cortexin and methylprednisolone groups and the control group in terms of neural fibrotic degeneration, myelin degeneration, axonal degeneration, normal myelin production, and edema.
    3 context sentences
    Summary · context
    The study was performed on 21 healthy rabbits.
    Summary · context
    The buccal branches of the left facial nerves of all the rabbits were pressed, and facial nerve paralysis occurred.
    Summary · context
    The rabbits were randomly divided into three equal groups: 3 mg/day cortexin intramuscularly, 1 mg/kg/day methylprednisolone intramuscularly, and 3 mg/day saline intramuscularly were administered for 10 days in Group I (cortexin group),
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with facial nerve trauma, cortexin and methylprednisolone did not differ significantly in neural fibrotic degeneration.

    In plain wordsIn rabbits, cortexin and methylprednisolone did not differ significantly in nerve fibrotic degeneration.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    No significant changeNeural fibrotic degeneration
    Study

    rabbitn: not reported in source

    Traumatic facial nerve paralysis
    Comparator
    Methylprednisolone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    3 mg/day · intramuscular · 10 daysAs given in this study (rabbit).

    Source sentences

    Summary
    When the cortexin and methylprednisolone groups were compared with each other, there was no significant difference between them, except for an increase in collagen fibers.
    4 context sentences
    Summary · context
    There was a significant difference between the cortexin and methylprednisolone groups and the control group in terms of neural fibrotic degeneration, myelin degeneration, axonal degeneration, normal myelin production, and edema.
    Summary · context
    The study was performed on 21 healthy rabbits.
    Summary · context
    The buccal branches of the left facial nerves of all the rabbits were pressed, and facial nerve paralysis occurred.
    Summary · context
    The rabbits were randomly divided into three equal groups: 3 mg/day cortexin intramuscularly, 1 mg/kg/day methylprednisolone intramuscularly, and 3 mg/day saline intramuscularly were administered for 10 days in Group I (cortexin group),
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with facial nerve trauma, cortexin and methylprednisolone did not differ significantly in myelin degeneration.

    In plain wordsIn rabbits, cortexin and methylprednisolone did not differ significantly in myelin degeneration.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    No significant changeMyelin degeneration
    Study

    rabbitn: not reported in source

    Traumatic facial nerve paralysis
    Comparator
    Methylprednisolone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    3 mg/day · intramuscular · 10 daysAs given in this study (rabbit).

    Source sentences

    Summary
    When the cortexin and methylprednisolone groups were compared with each other, there was no significant difference between them, except for an increase in collagen fibers.
    4 context sentences
    Summary · context
    There was a significant difference between the cortexin and methylprednisolone groups and the control group in terms of neural fibrotic degeneration, myelin degeneration, axonal degeneration, normal myelin production, and edema.
    Summary · context
    The study was performed on 21 healthy rabbits.
    Summary · context
    The buccal branches of the left facial nerves of all the rabbits were pressed, and facial nerve paralysis occurred.
    Summary · context
    The rabbits were randomly divided into three equal groups: 3 mg/day cortexin intramuscularly, 1 mg/kg/day methylprednisolone intramuscularly, and 3 mg/day saline intramuscularly were administered for 10 days in Group I (cortexin group),
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with facial nerve trauma, cortexin and methylprednisolone did not differ significantly in axonal degeneration.

    In plain wordsIn rabbits, cortexin and methylprednisolone did not differ significantly in axonal degeneration.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    No significant changeAxonal degeneration
    Study

    rabbitn: not reported in source

    Traumatic facial nerve paralysis
    Comparator
    Methylprednisolone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    3 mg/day · intramuscular · 10 daysAs given in this study (rabbit).

    Source sentences

    Summary
    When the cortexin and methylprednisolone groups were compared with each other, there was no significant difference between them, except for an increase in collagen fibers.
    4 context sentences
    Summary · context
    There was a significant difference between the cortexin and methylprednisolone groups and the control group in terms of neural fibrotic degeneration, myelin degeneration, axonal degeneration, normal myelin production, and edema.
    Summary · context
    The study was performed on 21 healthy rabbits.
    Summary · context
    The buccal branches of the left facial nerves of all the rabbits were pressed, and facial nerve paralysis occurred.
    Summary · context
    The rabbits were randomly divided into three equal groups: 3 mg/day cortexin intramuscularly, 1 mg/kg/day methylprednisolone intramuscularly, and 3 mg/day saline intramuscularly were administered for 10 days in Group I (cortexin group),
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with facial nerve trauma, cortexin and methylprednisolone did not differ significantly in normal myelin production.

    In plain wordsIn rabbits, cortexin and methylprednisolone did not differ significantly in normal myelin production.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    No significant changeNormal myelin production
    Study

    rabbitn: not reported in source

    Traumatic facial nerve paralysis
    Comparator
    Methylprednisolone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    3 mg/day · intramuscular · 10 daysAs given in this study (rabbit).

    Source sentences

    Summary
    When the cortexin and methylprednisolone groups were compared with each other, there was no significant difference between them, except for an increase in collagen fibers.
    4 context sentences
    Summary · context
    There was a significant difference between the cortexin and methylprednisolone groups and the control group in terms of neural fibrotic degeneration, myelin degeneration, axonal degeneration, normal myelin production, and edema.
    Summary · context
    The study was performed on 21 healthy rabbits.
    Summary · context
    The buccal branches of the left facial nerves of all the rabbits were pressed, and facial nerve paralysis occurred.
    Summary · context
    The rabbits were randomly divided into three equal groups: 3 mg/day cortexin intramuscularly, 1 mg/kg/day methylprednisolone intramuscularly, and 3 mg/day saline intramuscularly were administered for 10 days in Group I (cortexin group),
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with facial nerve trauma, cortexin and methylprednisolone did not differ significantly in edema.

    In plain wordsIn rabbits, cortexin and methylprednisolone did not differ significantly in swelling.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    No significant changeEdema
    Study

    rabbitn: not reported in source

    Traumatic facial nerve paralysis
    Comparator
    Methylprednisolone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    3 mg/day · intramuscular · 10 daysAs given in this study (rabbit).

    Source sentences

    Summary
    When the cortexin and methylprednisolone groups were compared with each other, there was no significant difference between them, except for an increase in collagen fibers.
    4 context sentences
    Summary · context
    There was a significant difference between the cortexin and methylprednisolone groups and the control group in terms of neural fibrotic degeneration, myelin degeneration, axonal degeneration, normal myelin production, and edema.
    Summary · context
    The study was performed on 21 healthy rabbits.
    Summary · context
    The buccal branches of the left facial nerves of all the rabbits were pressed, and facial nerve paralysis occurred.
    Summary · context
    The rabbits were randomly divided into three equal groups: 3 mg/day cortexin intramuscularly, 1 mg/kg/day methylprednisolone intramuscularly, and 3 mg/day saline intramuscularly were administered for 10 days in Group I (cortexin group),
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with facial nerve trauma, cortexin reduced the collagen fiber increase more than methylprednisolone.

    In plain wordsIn rabbits, cortexin reduced the collagen fiber increase more than methylprednisolone.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseCollagen fiber increase
    Study

    rabbitn: not reported in source

    Traumatic facial nerve paralysis
    Comparator
    Methylprednisolone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    3 mg/day · intramuscular · 10 daysAs given in this study (rabbit).

    Source sentences

    Summary
    Cortexin significantly reduced the collagen fiber increase to a greater extent than methylprednisolone.
    3 context sentences
    Summary · context
    The study was performed on 21 healthy rabbits.
    Summary · context
    The buccal branches of the left facial nerves of all the rabbits were pressed, and facial nerve paralysis occurred.
    Summary · context
    The rabbits were randomly divided into three equal groups: 3 mg/day cortexin intramuscularly, 1 mg/kg/day methylprednisolone intramuscularly, and 3 mg/day saline intramuscularly were administered for 10 days in Group I (cortexin group),
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with facial nerve trauma, electromyography did not differ significantly between cortexin and saline groups.

    In plain wordsIn rabbits, cortexin and saline did not differ significantly on muscle electrical recordings.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    No significant changeElectromyography
    Study

    rabbitn: not reported in source

    Traumatic facial nerve paralysis
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    3 mg/day · intramuscular · 10 daysAs given in this study (rabbit).

    Source sentences

    Summary
    The electromyography findings did not show any significant difference between the groups or within the groups.
    3 context sentences
    Summary · context
    The study was performed on 21 healthy rabbits.
    Summary · context
    The buccal branches of the left facial nerves of all the rabbits were pressed, and facial nerve paralysis occurred.
    Summary · context
    The rabbits were randomly divided into three equal groups: 3 mg/day cortexin intramuscularly, 1 mg/kg/day methylprednisolone intramuscularly, and 3 mg/day saline intramuscularly were administered for 10 days in Group I (cortexin group),
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rabbits with facial nerve trauma, electromyography did not differ significantly between cortexin and methylprednisolone groups.

    In plain wordsIn rabbits, cortexin and methylprednisolone did not differ significantly on muscle electrical recordings.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    No significant changeElectromyography
    Study

    rabbitn: not reported in source

    Traumatic facial nerve paralysis
    Comparator
    Methylprednisolone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    3 mg/day · intramuscular · 10 daysAs given in this study (rabbit).

    Source sentences

    Summary
    The electromyography findings did not show any significant difference between the groups or within the groups.
    3 context sentences
    Summary · context
    The study was performed on 21 healthy rabbits.
    Summary · context
    The buccal branches of the left facial nerves of all the rabbits were pressed, and facial nerve paralysis occurred.
    Summary · context
    The rabbits were randomly divided into three equal groups: 3 mg/day cortexin intramuscularly, 1 mg/kg/day methylprednisolone intramuscularly, and 3 mg/day saline intramuscularly were administered for 10 days in Group I (cortexin group),

Studies that did not test the peptide alone1

In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cortexin (cortical polypeptide complex).

  1. 10AnimalNot a test of Cortexin (cortical polypeptide complex) aloneAnimal study (in vivo)Efficacy outcome

    In rabbits with facial nerve trauma, electromyography did not change significantly within any group, including the cortexin group.

    In plain wordsIn rabbits, muscle electrical recordings did not change significantly within any group, including the cortexin group.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    No significant changeElectromyography over time
    Study

    rabbitn: not reported in source

    Traumatic facial nerve paralysis
    Comparator
    Baseline
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The electromyography findings did not show any significant difference between the groups or within the groups.
    3 context sentences
    Summary · context
    The study was performed on 21 healthy rabbits.
    Summary · context
    The buccal branches of the left facial nerves of all the rabbits were pressed, and facial nerve paralysis occurred.
    Summary · context
    The rabbits were randomly divided into three equal groups: 3 mg/day cortexin intramuscularly, 1 mg/kg/day methylprednisolone intramuscularly, and 3 mg/day saline intramuscularly were administered for 10 days in Group I (cortexin group),

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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