Skip to content

Study · Animal study (in vivo) · rat · 2016

3 results

Stable gastric pentadecapeptide BPC 157 and bupivacaine.

Zivanovic-Posilovic G, Balenovic D, Barisic I, Strinic D, Stambolija V, Udovicic M, Uzun S, Drmic D, Vlainic J, Bencic ML, Sindic A, Seiwerth S, Sikiric P

European journal of pharmacology1 Nov 2016Cited by 34 (Europe PMC)

PMID27815173 (opens in a new tab)DOI10.1016/j.ejphar.2016.10.035 (opens in a new tab)PepBankPUB-27815173
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats given bupivacaine, BPC‑157 largely counteracted the cardiac toxic effects when given 30 min before or 1 min after.

    In plain wordsIn rats given bupivacaine, BPC‑157 largely counteracted the heart rhythm problems it caused.

    Peptide
    BPC-157
    Outcome
    DecreaseBupivacaine-induced cardiac toxicity (arrhythmias, AV block, asystole)
    Study

    ratn: not reported in source

    bupivacaine cardiotoxicity
    Outcome group
    Cardiovascular events · Cardiovascular
    Studied dose
    50µg/kg, 10µg/kg, 10ng/kg, 10pg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    These were largely counteracted by BPC 157 administration (50µg/kg, 10µg/kg, 10ng/kg, or 10pg/kg IP) given 30min before or 1min after the bupivacaine injection.
    1 context sentence
    Summary · context
    Here, rats injected with bupivacaine (100mg/kg IP) exhibited bradycardia, AV-block, ventricular ectopies, ventricular tachycardia, T-wave elevation and asystole.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats given bupivacaine, BPC‑157 given 6 min later, after prolonged QRS intervals, markedly postponed the fatal outcome.

    In plain wordsIn rats given bupivacaine, BPC‑157 given late markedly delayed death.

    Peptide
    BPC-157
    Outcome
    IncreaseFatal outcome when BPC 157 given after prolonged QRS
    Study

    ratn: not reported in source

    bupivacaine cardiotoxicity
    Outcome group
    Mortality · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When BPC 157 was given 6min after bupivacaine administration, and after the development of prolonged QRS intervals (20ms), the fatal outcome was markedly postponed.
    1 context sentence
    Summary · context
    Here, rats injected with bupivacaine (100mg/kg IP) exhibited bradycardia, AV-block, ventricular ectopies, ventricular tachycardia, T-wave elevation and asystole.
  3. 03LabIn vitro (cells)Mechanism

    In HEK293 cells, bupivacaine-induced depolarization was inhibited in combination with BPC‑157.

    In plain wordsIn cells, BPC‑157 blocked the electrical change caused by bupivacaine.

    Peptide
    BPC-157
    Outcome
    DecreaseBupivacaine-induced cell depolarization
    Study

    humann: not reported in source

    HEK293 cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    1µmAs given in this study (human).

    Source sentences

    Summary
    Bupivacaine (1mM) alone caused depolarization of the cells, while in combination with BPC 157 (1µm), the bupivacaine-induced depolarization was inhibited.
    1 context sentence
    Summary · context
    Additionally, the effect of bupivacaine on cell membrane depolarization was explored by measuring membrane voltages (Vm) in HEK293 cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.