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Study · In vitro (cells) · 2017

6 results

Gly[14]-humanin inhibits ox-LDL uptake and stimulates cholesterol efflux in macrophage-derived foam cells.

Zhu WW, Wang SR, Liu ZH, Cao YJ, Wang F, Wang J, Liu CF, Xie Y, Xie Y, Zhang YL

Biochemical and biophysical research communications1 Nov 2016Cited by 18 (Europe PMC)

PMID27815075 (opens in a new tab)DOI10.1016/j.bbrc.2016.10.138 (opens in a new tab)PepBankPUB-27815075
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In RAW 264.7 macrophages, HNG reduced Dil-ox-LDL accumulation.

    In plain wordsIn lab-grown macrophages, HNG reduced the build-up of oxidized LDL cholesterol.

    Peptide
    Humanin
    Outcome
    DecreaseDil-ox-LDL accumulation
    Study

    n: not reported in source

    RAW 264.7 macrophages
    Outcome group
    Lipids · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Flow cytometry and live cell imaging results showed that HNG reduced Dil-ox-LDL accumulation in the RAW 264.7 macrophages.
    1 context sentence
    Summary · context
    This study was designed to investigate the role of [Gly14]-humanin (HNG) in lipid uptake and cholesterol efflux in RAW 264.7 macrophages.
  2. 02LabIn vitro (cells)Efficacy outcome

    In RAW 264.7 macrophages, HNG similarly reduced lipid accumulation as measured by cellular cholesterol content.

    In plain wordsIn lab-grown macrophages, HNG lowered the amount of cholesterol inside the cells.

    Peptide
    Humanin
    Outcome
    DecreaseCellular cholesterol content
    Study

    n: not reported in source

    RAW 264.7 macrophages
    Outcome group
    Lipids · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A similar result was obtained for lipid accumulation by measuring cellular cholesterol content.
    1 context sentence
    Summary · context
    This study was designed to investigate the role of [Gly14]-humanin (HNG) in lipid uptake and cholesterol efflux in RAW 264.7 macrophages.
  3. 03LabIn vitro (cells)Mechanism

    In RAW 264.7 macrophages, HNG pretreatment inhibited the ox-LDL-induced upregulation of CD36.

    In plain wordsIn lab-grown macrophages, HNG pretreatment blocked the rise in CD36, a protein that takes in oxidized LDL.

    Peptide
    Humanin
    Outcome
    DecreaseCD36 protein level after ox-LDL
    Study

    n: not reported in source

    RAW 264.7 macrophages
    Outcome group
    Lipids · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG pretreatment inhibited the upregulation of CD36 and LOX-1 levels, prompting the upregulation of ABCA1 and ABCG1 levels induced by ox-LDL.
    1 context sentence
    Summary · context
    This study was designed to investigate the role of [Gly14]-humanin (HNG) in lipid uptake and cholesterol efflux in RAW 264.7 macrophages.
  4. 04LabIn vitro (cells)Mechanism

    In RAW 264.7 macrophages, HNG pretreatment inhibited the ox-LDL-induced upregulation of LOX-1.

    In plain wordsIn lab-grown macrophages, HNG pretreatment blocked the rise in LOX-1, a protein that takes in oxidized LDL.

    Peptide
    Humanin
    Outcome
    DecreaseLOX-1 protein level after ox-LDL
    Study

    n: not reported in source

    RAW 264.7 macrophages
    Outcome group
    Lipids · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG pretreatment inhibited the upregulation of CD36 and LOX-1 levels, prompting the upregulation of ABCA1 and ABCG1 levels induced by ox-LDL.
    1 context sentence
    Summary · context
    This study was designed to investigate the role of [Gly14]-humanin (HNG) in lipid uptake and cholesterol efflux in RAW 264.7 macrophages.
  5. 05LabIn vitro (cells)Mechanism

    In RAW 264.7 macrophages, HNG pretreatment promoted the ox-LDL-induced upregulation of ABCA1.

    In plain wordsIn lab-grown macrophages, HNG pretreatment raised ABCA1, a protein that moves cholesterol out of cells.

    Peptide
    Humanin
    Outcome
    IncreaseABCA1 protein level after ox-LDL
    Study

    n: not reported in source

    RAW 264.7 macrophages
    Outcome group
    Lipids · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG pretreatment inhibited the upregulation of CD36 and LOX-1 levels, prompting the upregulation of ABCA1 and ABCG1 levels induced by ox-LDL.
    1 context sentence
    Summary · context
    This study was designed to investigate the role of [Gly14]-humanin (HNG) in lipid uptake and cholesterol efflux in RAW 264.7 macrophages.
  6. 06LabIn vitro (cells)Mechanism

    In RAW 264.7 macrophages, HNG pretreatment promoted the ox-LDL-induced upregulation of ABCG1.

    In plain wordsIn lab-grown macrophages, HNG pretreatment raised ABCG1, a protein that moves cholesterol out of cells.

    Peptide
    Humanin
    Outcome
    IncreaseABCG1 protein level after ox-LDL
    Study

    n: not reported in source

    RAW 264.7 macrophages
    Outcome group
    Lipids · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG pretreatment inhibited the upregulation of CD36 and LOX-1 levels, prompting the upregulation of ABCA1 and ABCG1 levels induced by ox-LDL.
    1 context sentence
    Summary · context
    This study was designed to investigate the role of [Gly14]-humanin (HNG) in lipid uptake and cholesterol efflux in RAW 264.7 macrophages.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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