Skip to content

Study · Animal study (in vivo) · mouse · 2017

3 results

Humanin ameliorates diazepam-induced memory deficit in mice.

Murakami M, Nagahama M, Maruyama T, Niikura T

Neuropeptides29 Oct 2016Cited by 16 (Europe PMC)

PMID27814910 (opens in a new tab)DOI10.1016/j.npep.2016.10.008 (opens in a new tab)PepBankPUB-27814910
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with diazepam-induced memory impairment, intraperitoneal S14G-HN reversed the memory deficit in the object recognition test.

    In plain wordsIn mice with diazepam-induced memory problems, the humanin derivative S14G-HN reversed the memory deficit.

    Peptide
    Humanin
    Outcome
    IncreaseObject recognition memory in diazepam-treated mice
    Study

    mousen: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Intraperitoneal injection of S14G-HN reversed the DZP-induced memory deficit
    1 context sentence
    Summary · context
    To understand the effects of HN on brain function, we tested the effect of S14G-HN on diazepam (DZP)-induced memory impairment and anxiety in mice using the object recognition test and zero-maze test, respectively.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice treated with diazepam, S14G-HN produced no significant change in behavioral markers of anxiety.

    In plain wordsIn mice, the humanin derivative S14G-HN did not change anxiety-related behavior.

    Peptide
    Humanin
    Outcome
    No significant changeAnxiety markers in the zero-maze test
    Study

    mousen: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    whereas no significant change was observed in behavioral markers of anxiety
    1 context sentence
    Summary · context
    To understand the effects of HN on brain function, we tested the effect of S14G-HN on diazepam (DZP)-induced memory impairment and anxiety in mice using the object recognition test and zero-maze test, respectively.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In mice, S14G-HN had no effect on locomotor activity in either the object recognition or the zero-maze test.

    In plain wordsIn mice, the humanin derivative S14G-HN did not change movement in either test.

    Peptide
    Humanin
    Outcome
    No significant changeLocomotor activity
    Study

    mousen: not reported in source

    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    S14G-HN had no effect on locomotor activity in either test, indicating that S14G-HN did not affect physical functioning or motivation.
    1 context sentence
    Summary · context
    To understand the effects of HN on brain function, we tested the effect of S14G-HN on diazepam (DZP)-induced memory impairment and anxiety in mice using the object recognition test and zero-maze test, respectively.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.