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Study · Animal study (in vivo) · mouse · 2016

8 results

Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease.

Mykicki N, Herrmann AM, Schwab N, Deenen R, Sparwasser T, Limmer A, Wachsmuth L, Klotz L, Köhrer K, Faber C, Wiendl H, Luger TA, Meuth SG, Loser K

Science translational medicine1 Oct 2016Cited by 56 (Europe PMC)

PMID27797962 (opens in a new tab)DOI10.1126/scitranslmed.aaf8732 (opens in a new tab)PepBankPUB-27797962
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice with EAE, NDP-MSH induced functional regulatory T cells.

    In plain wordsIn mice with an MS-like disease, NDP-MSH led to working regulatory T cells.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseFunctional Treg induction
    Study

    mousen: not reported in source

    EAE
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We show that a recently approved drug, Nle4-d-Phe7-α-melanocyte-stimulating hormone (NDP-MSH), induced functional Treg, resulting in amelioration of EAE progression in mice.
    1 context sentence
    Summary · context
    In MS and experimental autoimmune encephalomyelitis (EAE) in mice, Treg function is impaired.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with EAE, NDP-MSH ameliorated disease progression.

    In plain wordsIn mice with an MS-like disease, NDP-MSH slowed disease progression.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseEAE progression
    Study

    mousen: not reported in source

    EAE
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We show that a recently approved drug, Nle4-d-Phe7-α-melanocyte-stimulating hormone (NDP-MSH), induced functional Treg, resulting in amelioration of EAE progression in mice.
    1 context sentence
    Summary · context
    In MS and experimental autoimmune encephalomyelitis (EAE) in mice, Treg function is impaired.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with EAE, NDP-MSH prevented immune cell infiltration into the CNS.

    In plain wordsIn mice with an MS-like disease, NDP-MSH kept immune cells out of the brain and spinal cord.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseImmune cell infiltration into the CNS
    Study

    mousen: not reported in source

    EAE
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NDP-MSH also prevented immune cell infiltration into the CNS by restoring the integrity of the blood-brain barrier.
    1 context sentence
    Summary · context
    In MS and experimental autoimmune encephalomyelitis (EAE) in mice, Treg function is impaired.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with EAE, NDP-MSH restored the integrity of the blood-brain barrier.

    In plain wordsIn mice with an MS-like disease, NDP-MSH restored the blood-brain barrier.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseBlood-brain barrier integrity
    Study

    mousen: not reported in source

    EAE
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NDP-MSH also prevented immune cell infiltration into the CNS by restoring the integrity of the blood-brain barrier.
    1 context sentence
    Summary · context
    In MS and experimental autoimmune encephalomyelitis (EAE) in mice, Treg function is impaired.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with EAE, NDP-MSH exerted long-lasting neuroprotective effects.

    In plain wordsIn mice with an MS-like disease, NDP-MSH gave long-lasting protection to nerve cells.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableLong-lasting neuroprotection
    Study

    mousen: not reported in source

    EAE
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NDP-MSH exerted long-lasting neuroprotective effects in mice with EAE
    1 context sentence
    Summary · context
    In MS and experimental autoimmune encephalomyelitis (EAE) in mice, Treg function is impaired.
  6. 06LabIn vitro (cells)Efficacy outcome

    In mouse and human neurons in vitro, NDP-MSH prevented excitotoxic death.

    In plain wordsIn mouse and human nerve cells in the lab, NDP-MSH prevented cell death caused by overstimulation.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseExcitotoxic neuronal death
    Study

    mouse, humann: not reported in source

    neurons in vitro
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NDP-MSH exerted long-lasting neuroprotective effects in mice with EAE and prevented excitotoxic death and reestablished action potential firing in mouse and human neurons in vitro.
    1 context sentence
    Summary · context
    In MS and experimental autoimmune encephalomyelitis (EAE) in mice, Treg function is impaired.
  7. 07LabIn vitro (cells)Efficacy outcome

    In mouse and human neurons in vitro, NDP-MSH reestablished action potential firing.

    In plain wordsIn mouse and human nerve cells in the lab, NDP-MSH restored nerve firing.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseAction potential firing
    Study

    mouse, humann: not reported in source

    neurons in vitro
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NDP-MSH exerted long-lasting neuroprotective effects in mice with EAE and prevented excitotoxic death and reestablished action potential firing in mouse and human neurons in vitro.
    1 context sentence
    Summary · context
    In MS and experimental autoimmune encephalomyelitis (EAE) in mice, Treg function is impaired.
  8. 08LabIn vitro (cells)Mechanism

    In mouse and human neurons, neuroprotection by NDP-MSH was mediated via signaling through the melanocortin-1 and orphan nuclear 4 receptors.

    In plain wordsIn mouse and human nerve cells, NDP-MSH protected through the melanocortin-1 and orphan nuclear 4 receptors.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableReceptors mediating neuroprotection
    Study

    mouse, humann: not reported in source

    neurons in vitro
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neuroprotection by NDP-MSH was mediated via signaling through the melanocortin-1 and orphan nuclear 4 receptors in mouse and human neurons.
    1 context sentence
    Summary · context
    In MS and experimental autoimmune encephalomyelitis (EAE) in mice, Treg function is impaired.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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