In patients with type 1 diabetes, the first glucagon bolus raised glucose less after low- versus high-carbohydrate diet, 1.3 versus 2.7 mmol/L.
In plain wordsIn patients with type 1 diabetes, glucagon raised glucose less after a low-carbohydrate diet than after a high-carbohydrate diet.
- Peptide
- Glucagon
- Outcome
- DecreaseGlucose rise after first glucagon bolus
- Study
n = 10
- Comparator
- glucagon after high-carbohydrate diet
- Outcome group
- Glycemic control · Metabolic and weight
- Studied dose
- 100 µg · subcutaneousAs given in this study (human).
Measurements
- Incremental glucose rise
- 1.3 mmol/L
- low-carbohydrate diet
- SEM
- 0.3 mmol/L
- low-carbohydrate diet
- Incremental glucose rise
- 2.7 mmol/L
- high-carbohydrate diet
- SEM
- 0.4 mmol/L
- high-carbohydrate diet
- P value
- 0.002
- diet comparison
Source sentences
Compared with the HCD, the LCD resulted in lower incremental rises in PG after the first (mean ± SEM: 1.3 ± 0.3 vs. 2.7 ± 0.4 mmol/L, P = 0.002) and second glucagon bolus (4.1 ± 0.2 vs. 5.6 ± 0.5 mmol/L, P = 0.002).
2 context sentences(design, population, supporting numbers)
Ten patients with insulin pump-treated type 1 diabetes randomly completed 1 week of the HCD (≥250 g/day) and 1 week of the LCD (≤50 g/day).
When PG reached 3.9 mmol/L, 100 µg glucagon was given subcutaneously, followed by 500 µg glucagon 2 h later.