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Study · Animal study (in vivo) · rat · 2016

14 results

Carnosine ameliorates cognitive deficits in streptozotocin-induced diabetic rats: Possible involved mechanisms.

Ahshin-Majd S, Zamani S, Kiamari T, Kiasalari Z, Baluchnejadmojarad T, Roghani M

Peptides21 Oct 2016Cited by 54 (Europe PMC)

PMID27777064 (opens in a new tab)DOI10.1016/j.peptides.2016.10.008 (opens in a new tab)PepBankPUB-27777064
Publisher pagePubMedAsk about this study
Jump to 14 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, carnosine lowered serum glucose.

    In plain wordsIn diabetic rats, carnosine lowered serum glucose.

    Peptide
    L-carnosine
    Outcome
    DecreaseSerum glucose
    Study

    ratn: not reported in source

    STZ-diabetic rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    100mg/kg · intraperitoneal · 7 weeksAs given in this study (rat).

    Source sentences

    Summary
    Treatment of diabetic rats with carnosine at a dose of 100mg/kg at the end of the study lowered serum glucose, improved spatial recognition memory in Y maze, improved retention and recall in elevated plus maze, and prevented reduction of step-through latency in passive avoidance task.
    2 context sentences
    Summary · context
    Rats were divided into 5 groups: i.e., control, carnosine100-treated control, diabetic, and carnosine-treated diabetics (50 and 100mg/kg).
    Summary · context
    Carnosine was injected i.p. at doses of 50 or 100mg/kg for 7 weeks, started 1 week after induction of diabetes using streptozotocin.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, carnosine improved spatial recognition memory in the Y maze.

    In plain wordsIn diabetic rats, carnosine improved spatial recognition memory in the Y maze.

    Peptide
    L-carnosine
    Outcome
    IncreaseSpatial recognition memory
    Study

    ratn: not reported in source

    STZ-diabetic rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    100mg/kg · intraperitoneal · 7 weeksAs given in this study (rat).

    Source sentences

    Summary
    Treatment of diabetic rats with carnosine at a dose of 100mg/kg at the end of the study lowered serum glucose, improved spatial recognition memory in Y maze, improved retention and recall in elevated plus maze, and prevented reduction of step-through latency in passive avoidance task.
    2 context sentences
    Summary · context
    Rats were divided into 5 groups: i.e., control, carnosine100-treated control, diabetic, and carnosine-treated diabetics (50 and 100mg/kg).
    Summary · context
    Carnosine was injected i.p. at doses of 50 or 100mg/kg for 7 weeks, started 1 week after induction of diabetes using streptozotocin.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, carnosine improved retention and recall in the elevated plus maze.

    In plain wordsIn diabetic rats, carnosine improved retention and recall in the elevated plus maze.

    Peptide
    L-carnosine
    Outcome
    IncreaseRetention and recall
    Study

    ratn: not reported in source

    STZ-diabetic rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    100mg/kg · intraperitoneal · 7 weeksAs given in this study (rat).

    Source sentences

    Summary
    Treatment of diabetic rats with carnosine at a dose of 100mg/kg at the end of the study lowered serum glucose, improved spatial recognition memory in Y maze, improved retention and recall in elevated plus maze, and prevented reduction of step-through latency in passive avoidance task.
    2 context sentences
    Summary · context
    Rats were divided into 5 groups: i.e., control, carnosine100-treated control, diabetic, and carnosine-treated diabetics (50 and 100mg/kg).
    Summary · context
    Carnosine was injected i.p. at doses of 50 or 100mg/kg for 7 weeks, started 1 week after induction of diabetes using streptozotocin.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, carnosine prevented the reduction in step-through latency during passive avoidance.

    In plain wordsIn diabetic rats, carnosine prevented the reduction in passive avoidance latency.

    Peptide
    L-carnosine
    Outcome
    IncreasePassive avoidance latency
    Study

    ratn: not reported in source

    STZ-diabetic rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    100mg/kg · intraperitoneal · 7 weeksAs given in this study (rat).

    Source sentences

    Summary
    Treatment of diabetic rats with carnosine at a dose of 100mg/kg at the end of the study lowered serum glucose, improved spatial recognition memory in Y maze, improved retention and recall in elevated plus maze, and prevented reduction of step-through latency in passive avoidance task.
    2 context sentences
    Summary · context
    Rats were divided into 5 groups: i.e., control, carnosine100-treated control, diabetic, and carnosine-treated diabetics (50 and 100mg/kg).
    Summary · context
    Carnosine was injected i.p. at doses of 50 or 100mg/kg for 7 weeks, started 1 week after induction of diabetes using streptozotocin.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine reduced hippocampal acetylcholinesterase activity.

    In plain wordsIn diabetic rats, carnosine reduced hippocampal acetylcholinesterase activity.

    Peptide
    L-carnosine
    Outcome
    DecreaseHippocampal acetylcholinesterase activity
    Study

    ratn: not reported in source

    STZ-diabetic rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100mg/kg · intraperitoneal · 7 weeksAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, carnosine at a dose of 100mg/kg reduced hippocampal acetylcholinesterase (AChE) activity, lowered lipid peroxidation, and improved superoxide dismutase (SOD) activity and non-enzymatic antioxidant defense element glutathione (GSH), but not activity of catalase.
    2 context sentences
    Summary · context
    Rats were divided into 5 groups: i.e., control, carnosine100-treated control, diabetic, and carnosine-treated diabetics (50 and 100mg/kg).
    Summary · context
    Carnosine was injected i.p. at doses of 50 or 100mg/kg for 7 weeks, started 1 week after induction of diabetes using streptozotocin.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine lowered hippocampal lipid peroxidation.

    In plain wordsIn diabetic rats, carnosine lowered hippocampal lipid peroxidation.

    Peptide
    L-carnosine
    Outcome
    DecreaseLipid peroxidation
    Study

    ratn: not reported in source

    STZ-diabetic rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100mg/kg · intraperitoneal · 7 weeksAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, carnosine at a dose of 100mg/kg reduced hippocampal acetylcholinesterase (AChE) activity, lowered lipid peroxidation, and improved superoxide dismutase (SOD) activity and non-enzymatic antioxidant defense element glutathione (GSH), but not activity of catalase.
    2 context sentences
    Summary · context
    Rats were divided into 5 groups: i.e., control, carnosine100-treated control, diabetic, and carnosine-treated diabetics (50 and 100mg/kg).
    Summary · context
    Carnosine was injected i.p. at doses of 50 or 100mg/kg for 7 weeks, started 1 week after induction of diabetes using streptozotocin.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine improved hippocampal superoxide dismutase activity.

    In plain wordsIn diabetic rats, carnosine improved hippocampal superoxide dismutase activity.

    Peptide
    L-carnosine
    Outcome
    IncreaseSuperoxide dismutase activity
    Study

    ratn: not reported in source

    STZ-diabetic rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100mg/kg · intraperitoneal · 7 weeksAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, carnosine at a dose of 100mg/kg reduced hippocampal acetylcholinesterase (AChE) activity, lowered lipid peroxidation, and improved superoxide dismutase (SOD) activity and non-enzymatic antioxidant defense element glutathione (GSH), but not activity of catalase.
    2 context sentences
    Summary · context
    Rats were divided into 5 groups: i.e., control, carnosine100-treated control, diabetic, and carnosine-treated diabetics (50 and 100mg/kg).
    Summary · context
    Carnosine was injected i.p. at doses of 50 or 100mg/kg for 7 weeks, started 1 week after induction of diabetes using streptozotocin.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine improved hippocampal glutathione antioxidant defense.

    In plain wordsIn diabetic rats, carnosine improved hippocampal glutathione antioxidant defense.

    Peptide
    L-carnosine
    Outcome
    IncreaseGlutathione antioxidant defense
    Study

    ratn: not reported in source

    STZ-diabetic rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100mg/kg · intraperitoneal · 7 weeksAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, carnosine at a dose of 100mg/kg reduced hippocampal acetylcholinesterase (AChE) activity, lowered lipid peroxidation, and improved superoxide dismutase (SOD) activity and non-enzymatic antioxidant defense element glutathione (GSH), but not activity of catalase.
    2 context sentences
    Summary · context
    Rats were divided into 5 groups: i.e., control, carnosine100-treated control, diabetic, and carnosine-treated diabetics (50 and 100mg/kg).
    Summary · context
    Carnosine was injected i.p. at doses of 50 or 100mg/kg for 7 weeks, started 1 week after induction of diabetes using streptozotocin.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine did not improve catalase activity.

    In plain wordsIn diabetic rats, carnosine did not improve catalase activity.

    Peptide
    L-carnosine
    Outcome
    No significant changeCatalase activity
    Study

    ratn: not reported in source

    STZ-diabetic rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100mg/kg · intraperitoneal · 7 weeksAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, carnosine at a dose of 100mg/kg reduced hippocampal acetylcholinesterase (AChE) activity, lowered lipid peroxidation, and improved superoxide dismutase (SOD) activity and non-enzymatic antioxidant defense element glutathione (GSH), but not activity of catalase.
    2 context sentences
    Summary · context
    Rats were divided into 5 groups: i.e., control, carnosine100-treated control, diabetic, and carnosine-treated diabetics (50 and 100mg/kg).
    Summary · context
    Carnosine was injected i.p. at doses of 50 or 100mg/kg for 7 weeks, started 1 week after induction of diabetes using streptozotocin.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine decreased hippocampal NF-κB levels.

    In plain wordsIn diabetic rats, carnosine decreased hippocampal NF-κB levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseHippocampal NF-κB
    Study

    ratn: not reported in source

    STZ-diabetic rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100mg/kg · intraperitoneal · 7 weeksAs given in this study (rat).

    Source sentences

    Summary
    Meanwhile, hippocampal level of nuclear factor-kappaB (NF-κB), tumor necrosis factor α (TNF-α), and glial fibrillary acidic protein (GFAP) decreased and level of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase 1 (HO-1) increased upon treatment of diabetic group with carnosine a…
    2 context sentences
    Summary · context
    Rats were divided into 5 groups: i.e., control, carnosine100-treated control, diabetic, and carnosine-treated diabetics (50 and 100mg/kg).
    Summary · context
    Carnosine was injected i.p. at doses of 50 or 100mg/kg for 7 weeks, started 1 week after induction of diabetes using streptozotocin.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine decreased hippocampal TNF-α levels.

    In plain wordsIn diabetic rats, carnosine decreased hippocampal TNF-α levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseHippocampal TNF-α
    Study

    ratn: not reported in source

    STZ-diabetic rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100mg/kg · intraperitoneal · 7 weeksAs given in this study (rat).

    Source sentences

    Summary
    Meanwhile, hippocampal level of nuclear factor-kappaB (NF-κB), tumor necrosis factor α (TNF-α), and glial fibrillary acidic protein (GFAP) decreased and level of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase 1 (HO-1) increased upon treatment of diabetic group with carnosine a…
    2 context sentences
    Summary · context
    Rats were divided into 5 groups: i.e., control, carnosine100-treated control, diabetic, and carnosine-treated diabetics (50 and 100mg/kg).
    Summary · context
    Carnosine was injected i.p. at doses of 50 or 100mg/kg for 7 weeks, started 1 week after induction of diabetes using streptozotocin.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine decreased hippocampal GFAP levels.

    In plain wordsIn diabetic rats, carnosine decreased hippocampal GFAP levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseHippocampal GFAP
    Study

    ratn: not reported in source

    STZ-diabetic rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100mg/kg · intraperitoneal · 7 weeksAs given in this study (rat).

    Source sentences

    Summary
    Meanwhile, hippocampal level of nuclear factor-kappaB (NF-κB), tumor necrosis factor α (TNF-α), and glial fibrillary acidic protein (GFAP) decreased and level of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase 1 (HO-1) increased upon treatment of diabetic group with carnosine a…
    2 context sentences
    Summary · context
    Rats were divided into 5 groups: i.e., control, carnosine100-treated control, diabetic, and carnosine-treated diabetics (50 and 100mg/kg).
    Summary · context
    Carnosine was injected i.p. at doses of 50 or 100mg/kg for 7 weeks, started 1 week after induction of diabetes using streptozotocin.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine increased hippocampal Nrf2 levels.

    In plain wordsIn diabetic rats, carnosine increased hippocampal Nrf2 levels.

    Peptide
    L-carnosine
    Outcome
    IncreaseHippocampal Nrf2
    Study

    ratn: not reported in source

    STZ-diabetic rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100mg/kg · intraperitoneal · 7 weeksAs given in this study (rat).

    Source sentences

    Summary
    Meanwhile, hippocampal level of nuclear factor-kappaB (NF-κB), tumor necrosis factor α (TNF-α), and glial fibrillary acidic protein (GFAP) decreased and level of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase 1 (HO-1) increased upon treatment of diabetic group with carnosine a…
    2 context sentences
    Summary · context
    Rats were divided into 5 groups: i.e., control, carnosine100-treated control, diabetic, and carnosine-treated diabetics (50 and 100mg/kg).
    Summary · context
    Carnosine was injected i.p. at doses of 50 or 100mg/kg for 7 weeks, started 1 week after induction of diabetes using streptozotocin.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine increased hippocampal HO-1 levels.

    In plain wordsIn diabetic rats, carnosine increased hippocampal HO-1 levels.

    Peptide
    L-carnosine
    Outcome
    IncreaseHippocampal HO-1
    Study

    ratn: not reported in source

    STZ-diabetic rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100mg/kg · intraperitoneal · 7 weeksAs given in this study (rat).

    Source sentences

    Summary
    Meanwhile, hippocampal level of nuclear factor-kappaB (NF-κB), tumor necrosis factor α (TNF-α), and glial fibrillary acidic protein (GFAP) decreased and level of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase 1 (HO-1) increased upon treatment of diabetic group with carnosine a…
    2 context sentences
    Summary · context
    Rats were divided into 5 groups: i.e., control, carnosine100-treated control, diabetic, and carnosine-treated diabetics (50 and 100mg/kg).
    Summary · context
    Carnosine was injected i.p. at doses of 50 or 100mg/kg for 7 weeks, started 1 week after induction of diabetes using streptozotocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

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