Kisspeptin-10 and the G protein-coupled receptor 54 are differentially expressed in the canine pregnant uterus and trophoblast cells.

Schäfer-Somi S, Ay SS, Kaya D, Sözmen M, Beceriklisoy HB, Ağaoğlu AR, Fındık M, van Haeften T, Aslan S

Reproduction in domestic animals = Zuchthygiene23 Oct 2016Cited by 20 (Europe PMC)

PMID27774662DOI10.1111/rda.12818PepBankPUB-27774662

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured7

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In the canine uterus, kiss1 gene expression did not differ between non-pregnant and gestational groups.
In plain wordsIn dogs, the gene for the body's own kisspeptin was active at similar levels in non-pregnant and pregnant uteri.
Peptide
Kisspeptin-10
Outcome
No significant changekiss1 gene expression across groups
Study
dogn = 33
Canine uterus and trophoblast tissue
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
whereas there was no difference found between groups for kiss1.
1 context sentence(design, population, supporting numbers)
Summary · context
Uterine tissue was collected from bitches after ovariohysterectomy at different times after ovulation. Samples were assigned to four groups: metestrous non-pregnant, day 10-12, n = 4; pre-implantation, day 10-12, n = 9; post-implantation, day 18-25, n = 13; mid-gestation, day 30-40, n = 7.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2777466201
02AnimalEndogenous levelAnimal study (in vivo)Other
In the canine uterus, expression of the kisspeptin receptor GPR54 was higher before embryo adhesion than during post-implantation and mid-gestation.
In plain wordsIn dogs, the gene for the receptor of the body's own kisspeptin was more active before embryo attachment than later in pregnancy.
Peptide
Kisspeptin-10
Outcome
DecreaseGPR54 (kisspeptin receptor) gene expression
Study
dogn = 33
Canine uterus and trophoblast tissue
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Expression of GPR54 was higher before embryo adhesion than during post-implantation and mid-gestation (p < .05)
1 context sentence(design, population, supporting numbers)
Summary · context
Uterine tissue was collected from bitches after ovariohysterectomy at different times after ovulation. Samples were assigned to four groups: metestrous non-pregnant, day 10-12, n = 4; pre-implantation, day 10-12, n = 9; post-implantation, day 18-25, n = 13; mid-gestation, day 30-40, n = 7.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2777466202
03AnimalEndogenous levelAnimal study (in vivo)Other
In the canine uterus, KP-10 expression was higher in the non-pregnant uterus than in all gestational periods except the pre-implantation period, indicating a pregnancy-related downregulation.
In plain wordsIn dogs, the body's own kisspeptin‑10 was higher in non-pregnant uteri than in most stages of pregnancy.
Peptide
Kisspeptin-10
Outcome
DecreaseKP-10 immunoreactivity in non-pregnant versus pregnant uterus
Study
dogn: not reported in source
Canine uterus and trophoblast tissue
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Except during the pre-implantation period, KP-10 expression was higher in the non-pregnant uterus compared to all gestational periods investigated, indicating a pregnancy-related downregulation.
1 context sentence(design, population, supporting numbers)
Summary · context
Uterine tissue was collected from bitches after ovariohysterectomy at different times after ovulation. Samples were assigned to four groups: metestrous non-pregnant, day 10-12, n = 4; pre-implantation, day 10-12, n = 9; post-implantation, day 18-25, n = 13; mid-gestation, day 30-40, n = 7.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2777466203
04AnimalEndogenous levelAnimal study (in vivo)Other
In the pre-implantation canine uterus, KP-10 was present in larger vessels only.
In plain wordsIn dogs before embryo implantation, the body's own kisspeptin‑10 appeared only in larger blood vessels of the uterus.
Peptide
Kisspeptin-10
Outcome
Not applicableKP-10 localization in uterine vessels
Study
dogn: not reported in source
Canine uterus and trophoblast tissue
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
In the pre-implantation period, KP-10 was present in larger vessels only
1 context sentence(design, population, supporting numbers)
Summary · context
Uterine tissue was collected from bitches after ovariohysterectomy at different times after ovulation. Samples were assigned to four groups: metestrous non-pregnant, day 10-12, n = 4; pre-implantation, day 10-12, n = 9; post-implantation, day 18-25, n = 13; mid-gestation, day 30-40, n = 7.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2777466204
05AnimalEndogenous levelAnimal study (in vivo)Other
In the post-implantation canine uterus, KP-10 was present in superficial uterine glands.
In plain wordsIn dogs after embryo implantation, the body's own kisspeptin‑10 appeared in the outer glands of the uterus.
Peptide
Kisspeptin-10
Outcome
Not applicableKP-10 localization in superficial uterine glands
Study
dogn: not reported in source
Canine uterus and trophoblast tissue
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
KP-10 was present in superficial uterine glands
1 context sentence(design, population, supporting numbers)
Summary · context
Uterine tissue was collected from bitches after ovariohysterectomy at different times after ovulation. Samples were assigned to four groups: metestrous non-pregnant, day 10-12, n = 4; pre-implantation, day 10-12, n = 9; post-implantation, day 18-25, n = 13; mid-gestation, day 30-40, n = 7.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2777466205
06AnimalEndogenous levelAnimal study (in vivo)Other
In canine uterine myocytes, KP-10 staining was highest in the non-pregnant uterus.
In plain wordsIn dogs, the body's own kisspeptin‑10 in uterine muscle cells was highest in non-pregnant uteri.
Peptide
Kisspeptin-10
Outcome
DecreaseKP-10 staining in uterine myocytes
Study
dogn: not reported in source
Canine uterus and trophoblast tissue
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
In myocytes, the highest staining for KP-10 was seen in the non-pregnant uterus
1 context sentence(design, population, supporting numbers)
Summary · context
Uterine tissue was collected from bitches after ovariohysterectomy at different times after ovulation. Samples were assigned to four groups: metestrous non-pregnant, day 10-12, n = 4; pre-implantation, day 10-12, n = 9; post-implantation, day 18-25, n = 13; mid-gestation, day 30-40, n = 7.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2777466206
07AnimalEndogenous levelAnimal study (in vivo)Other
In the canine uterus, syncytiotrophoblast cells stained for KP-10 in post-implantation and mid-gestation.
In plain wordsIn dogs, placental cells stained for the body's own kisspeptin‑10 after implantation and in mid-pregnancy.
Peptide
Kisspeptin-10
Outcome
Not applicableKP-10 staining in syncytiotrophoblast cells
Study
dogn: not reported in source
Canine uterus and trophoblast tissue
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Syncytiotrophoblast cells stained for both KP-10 and GPR54 in post-implantation and mid-gestation
1 context sentence(design, population, supporting numbers)
Summary · context
Uterine tissue was collected from bitches after ovariohysterectomy at different times after ovulation. Samples were assigned to four groups: metestrous non-pregnant, day 10-12, n = 4; pre-implantation, day 10-12, n = 9; post-implantation, day 18-25, n = 13; mid-gestation, day 30-40, n = 7.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2777466207

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.