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Study · Animal study (in vivo) · rat · 2016

9 results

Exogenous NAD(+) administration significantly protects against myocardial ischemia/reperfusion injury in rat model.

Zhang Y, Wang B, Fu X, Guan S, Han W, Zhang J, Gan Q, Fang W, Ying W, Qu X

American journal of translational research15 Aug 2016Cited by 45 (Europe PMC)

PMID27648125 (opens in a new tab)PMCIDPMC5009387 (opens in a new tab)PepBankPUB-27648125
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with myocardial I/R injury, NAD+ dose-dependently reduced myocardial infarct.

    In plain wordsIn rats with heart I/R injury, NAD+ reduced heart infarct as the dose increased.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseMyocardial infarct reduction dose response
    Study

    ratn: not reported in source

    myocardial ischemia/reperfusion injury
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10-20 mg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Our study found that administration of 10-20 mg/kg NAD(+) can dose dependently reduce myocardial infarct induced by I/R, with an approximately 85% reduction of the infarct at the dosage of 20 mg/kg NAD(+).
    1 context sentence
    Summary · context
    To test our hypothesis that intravenous administration of NAD(+) can attenuate I/R injury by reducing apoptotic damage and enhancing antioxidant capacity, we used a rat mode of myocardial I/R.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with myocardial I/R injury, NAD+ at 20 mg/kg reduced infarct by approximately 85%.

    In plain wordsIn rats with heart I/R injury, NAD+ at 20 mg/kg reduced infarct by approximately 85%.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseMyocardial infarct at 20 mg/kg
    Study

    ratn: not reported in source

    myocardial ischemia/reperfusion injury
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    20 mg/kg · intravenousAs given in this study (rat).

    Measurements

    infarct reduction
    ≈ 85%
    20 mg/kg NAD(+)

    Source sentences

    Summary
    Our study found that administration of 10-20 mg/kg NAD(+) can dose dependently reduce myocardial infarct induced by I/R, with an approximately 85% reduction of the infarct at the dosage of 20 mg/kg NAD(+).
    1 context sentence
    Summary · context
    To test our hypothesis that intravenous administration of NAD(+) can attenuate I/R injury by reducing apoptotic damage and enhancing antioxidant capacity, we used a rat mode of myocardial I/R.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with myocardial I/R injury, injected NAD+ significantly reduced apoptotic heart damage.

    In plain wordsIn rats with heart I/R injury, injected NAD+ reduced damage from cell death.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseApoptotic heart damage
    Study

    ratn: not reported in source

    myocardial ischemia/reperfusion injury
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    We further found that the injection of NAD(+) can significantly decrease I/R-induced apoptotic damage in the heart: NAD(+) administration can both decrease the TUNEL signals, Bax, cleaved caspase-3 levels and increase the Bcl-XL levels in the rats that are subjected to myocardial I/R injury.
    1 context sentence
    Summary · context
    To test our hypothesis that intravenous administration of NAD(+) can attenuate I/R injury by reducing apoptotic damage and enhancing antioxidant capacity, we used a rat mode of myocardial I/R.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial I/R injury, NAD+ decreased cardiac TUNEL signals.

    In plain wordsIn rats with heart I/R injury, NAD+ reduced TUNEL signals in the heart.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseTUNEL signals
    Study

    ratn: not reported in source

    myocardial ischemia/reperfusion injury
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    We further found that the injection of NAD(+) can significantly decrease I/R-induced apoptotic damage in the heart: NAD(+) administration can both decrease the TUNEL signals, Bax, cleaved caspase-3 levels and increase the Bcl-XL levels in the rats that are subjected to myocardial I/R injury.
    1 context sentence
    Summary · context
    To test our hypothesis that intravenous administration of NAD(+) can attenuate I/R injury by reducing apoptotic damage and enhancing antioxidant capacity, we used a rat mode of myocardial I/R.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial I/R injury, NAD+ decreased cardiac Bax levels.

    In plain wordsIn rats with heart I/R injury, NAD+ reduced Bax levels in the heart.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseBax levels
    Study

    ratn: not reported in source

    myocardial ischemia/reperfusion injury
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    We further found that the injection of NAD(+) can significantly decrease I/R-induced apoptotic damage in the heart: NAD(+) administration can both decrease the TUNEL signals, Bax, cleaved caspase-3 levels and increase the Bcl-XL levels in the rats that are subjected to myocardial I/R injury.
    1 context sentence
    Summary · context
    To test our hypothesis that intravenous administration of NAD(+) can attenuate I/R injury by reducing apoptotic damage and enhancing antioxidant capacity, we used a rat mode of myocardial I/R.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial I/R injury, NAD+ decreased cardiac cleaved caspase-3 levels.

    In plain wordsIn rats with heart I/R injury, NAD+ reduced cleaved caspase-3 levels in the heart.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseCleaved caspase-3 levels
    Study

    ratn: not reported in source

    myocardial ischemia/reperfusion injury
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    We further found that the injection of NAD(+) can significantly decrease I/R-induced apoptotic damage in the heart: NAD(+) administration can both decrease the TUNEL signals, Bax, cleaved caspase-3 levels and increase the Bcl-XL levels in the rats that are subjected to myocardial I/R injury.
    1 context sentence
    Summary · context
    To test our hypothesis that intravenous administration of NAD(+) can attenuate I/R injury by reducing apoptotic damage and enhancing antioxidant capacity, we used a rat mode of myocardial I/R.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial I/R injury, NAD+ increased cardiac Bcl-XL levels.

    In plain wordsIn rats with heart I/R injury, NAD+ increased Bcl-XL levels in the heart.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseBcl-XL levels
    Study

    ratn: not reported in source

    myocardial ischemia/reperfusion injury
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    We further found that the injection of NAD(+) can significantly decrease I/R-induced apoptotic damage in the heart: NAD(+) administration can both decrease the TUNEL signals, Bax, cleaved caspase-3 levels and increase the Bcl-XL levels in the rats that are subjected to myocardial I/R injury.
    1 context sentence
    Summary · context
    To test our hypothesis that intravenous administration of NAD(+) can attenuate I/R injury by reducing apoptotic damage and enhancing antioxidant capacity, we used a rat mode of myocardial I/R.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial I/R injury, NAD+ significantly attenuated the decrease in cardiac SOD activity.

    In plain wordsIn rats with heart I/R injury, NAD+ reduced the loss of SOD activity in the heart.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseSOD activity
    Study

    ratn: not reported in source

    myocardial ischemia/reperfusion injury
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    NAD(+) administration can also significantly attenuate I/R-induced decreases in SOD activity and SOD-2 protein levels in the hearts.
    1 context sentence
    Summary · context
    To test our hypothesis that intravenous administration of NAD(+) can attenuate I/R injury by reducing apoptotic damage and enhancing antioxidant capacity, we used a rat mode of myocardial I/R.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats with myocardial I/R injury, NAD+ significantly attenuated the decrease in cardiac SOD-2 protein levels.

    In plain wordsIn rats with heart I/R injury, NAD+ reduced the loss of SOD-2 protein in the heart.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseSOD-2 protein levels
    Study

    ratn: not reported in source

    myocardial ischemia/reperfusion injury
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    NAD(+) administration can also significantly attenuate I/R-induced decreases in SOD activity and SOD-2 protein levels in the hearts.
    1 context sentence
    Summary · context
    To test our hypothesis that intravenous administration of NAD(+) can attenuate I/R injury by reducing apoptotic damage and enhancing antioxidant capacity, we used a rat mode of myocardial I/R.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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