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Study · Animal study (in vivo) · mouse · 2016

2 results

Effects of the GLP-1 Agonist Exendin-4 on Intravenous Ethanol Self-Administration in Mice.

Sørensen G, Caine SB, Thomsen M

Alcoholism, clinical and experimental research31 Aug 2016Cited by 60 (Europe PMC)

PMID27579999 (opens in a new tab)PMCIDPMC5048549 (opens in a new tab)DOI10.1111/acer.13199 (opens in a new tab)PepBankPUB-27579999
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice acquiring ethanol self-administration, exendin‑4 decreased intravenous ethanol intake by at least 70%.

    In plain wordsIn mice that learned to self-administer ethanol, exendin‑4 reduced intravenous ethanol intake by at least 70%.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseIntravenous ethanol intake
    Study

    mousen: not reported in source

    C57BL/6J mice trained for intravenous ethanol self-administration
    Outcome group
    Appetite and food intake · Mental health and mood
    Studied dose
    3.2 μg/kg · Acute pretreatmentAs given in this study (mouse).

    Measurements

    Ethanol intake reduction
    ≥ 70%
    exendin-4

    Source sentences

    Summary
    In mice that acquired self-administration, EtOH intake was high, indeed, reaching toxic doses; 3.2 μg/kg Exendin-4 decreased intravenous EtOH intake by at least 70%, but had no significant effect on food-maintained operant responding.
    2 context sentences
    Summary · context
    We trained experimentally naïve, free-fed C57BL/6J mice to self-administer EtOH intravenously.
    Summary · context
    Once stable EtOH intake was acquired, we tested the effect of acute pretreatment with the GLP-1 receptor agonist Exendin-4.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, exendin‑4 had no significant effect on food-maintained operant responding.

    In plain wordsIn mice, exendin‑4 did not significantly change behavior reinforced by food.

    Peptide
    Exenatide (exendin-4)
    Outcome
    No significant changeFood-maintained operant responding
    Study

    mousen: not reported in source

    C57BL/6J mice trained for intravenous ethanol self-administration
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    3.2 μg/kg · Acute pretreatmentAs given in this study (mouse).

    Source sentences

    Summary
    In mice that acquired self-administration, EtOH intake was high, indeed, reaching toxic doses; 3.2 μg/kg Exendin-4 decreased intravenous EtOH intake by at least 70%, but had no significant effect on food-maintained operant responding.
    2 context sentences
    Summary · context
    We trained experimentally naïve, free-fed C57BL/6J mice to self-administer EtOH intravenously.
    Summary · context
    Once stable EtOH intake was acquired, we tested the effect of acute pretreatment with the GLP-1 receptor agonist Exendin-4.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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