In post-mortem prefrontal cortex, expression of the humanin-like-8 gene (MTRNRL8) was altered in depression.
In plain wordsIn brain tissue from people who had depression, the body's own humanin-like-8 gene activity was altered.
- Peptide
- Humanin
- Outcome
- Direction not reportedHumanin-like-8 (MTRNRL8) gene expression in depression
- Study
n = 59
- Outcome group
- Anxiety and mood · Mental health and mood
Source sentences
In depression, altered genes include humanin-like-8 (MTRNRL8)
1 context sentence(design, population, supporting numbers)
Using RNA-seq, we examined whole-exome gene and exon expression in non-psychiatric controls (CON, N=29), DSM-IV major depressive disorder suicides (MDD-S, N=21) and MDD non-suicides (MDD, N=9) in the dorsal lateral prefrontal cortex (Brodmann Area 9) of sudden death medication-free individuals post mortem.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.