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Study · Measured the body's own peptide · 2016

7 results

Thymosin beta 4 silencing suppresses proliferation and invasion of non-small cell lung cancer cells by repressing Notch1 activation.

Huang D, Wang S, Wang A, Chen X, Zhang H

Acta biochimica et biophysica Sinica12 Aug 2016Cited by 19 (Europe PMC)

PMID27521796 (opens in a new tab)DOI10.1093/abbs/gmw070 (opens in a new tab)PepBankPUB-27521796
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    Tβ4 expression was increased in non-small cell lung cancer tissues and cell lines.

    In plain wordsNatural Tβ4 levels were higher in lung cancer tissues and cell lines.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTβ4 expression in NSCLC tissues and cell lines
    Study

    n: not reported in source

    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    In the present study, we confirmed that Tβ4 expression was increased in NSCLC tissues and cell lines.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone6

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    Tβ4 gene silencing in lung cancer cells decreased tumor growth in vivo.

    In plain wordsIn animals, tumors from lung cancer cells with the Tβ4 gene switched off grew less.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseTumor growth in vivo after Tβ4 silencing
    Study

    n: not reported in source

    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Tβ4 gene silencing in A549 and H1299 cells inhibited cell proliferation, migration, and invasion in vitro and decreased tumor growth in vivo

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Activity measurement

    In A549 and H1299 lung cancer cells, Tβ4 gene silencing inhibited cell proliferation in vitro.

    In plain wordsIn lung cancer cells, switching off the Tβ4 gene slowed cell growth.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCell proliferation after Tβ4 silencing
    Study

    n: not reported in source

    A549 and H1299 NSCLC cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Tβ4 gene silencing in A549 and H1299 cells inhibited cell proliferation, migration, and invasion in vitro

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Activity measurement

    In A549 and H1299 lung cancer cells, Tβ4 gene silencing inhibited cell migration in vitro.

    In plain wordsIn lung cancer cells, switching off the Tβ4 gene reduced cell movement.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCell migration after Tβ4 silencing
    Study

    n: not reported in source

    A549 and H1299 NSCLC cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Tβ4 gene silencing in A549 and H1299 cells inhibited cell proliferation, migration, and invasion in vitro

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Activity measurement

    In A549 and H1299 lung cancer cells, Tβ4 gene silencing inhibited cell invasion in vitro.

    In plain wordsIn lung cancer cells, switching off the Tβ4 gene reduced cell invasion.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCell invasion after Tβ4 silencing
    Study

    n: not reported in source

    A549 and H1299 NSCLC cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Tβ4 gene silencing in A549 and H1299 cells inhibited cell proliferation, migration, and invasion in vitro

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  5. 06LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    Tβ4 gene silencing significantly decreased Notch1 activation in non-small cell lung cancer cells.

    In plain wordsIn lung cancer cells, switching off the Tβ4 gene lowered Notch1 activation.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseNotch1 activation after Tβ4 silencing
    Study

    n: not reported in source

    Tβ4 gene-silenced NSCLC cells
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    Mechanistic investigations revealed a significant decrease in Notch1 activation in Tβ4 gene-silenced cells.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  6. 07LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    Restoring Notch1 expression attenuated the effect of Tβ4 silencing in non-small cell lung cancer cells.

    In plain wordsIn lung cancer cells, putting Notch1 back reduced the effect of switching off the Tβ4 gene.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    MixedRescue of Tβ4 silencing effect by Notch1 restoration
    Study

    n: not reported in source

    Tβ4-silenced NSCLC cells
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    Moreover, restoring the Notch1 expression attenuated the function of Tβ4 silencing in NSCLC cells.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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