Skip to content

Study · Animal study (in vivo) · mouse · 2016

14 results

Protection of mitochondria prevents high-fat diet-induced glomerulopathy and proximal tubular injury.

Szeto HH, Liu S, Soong Y, Alam N, Prusky GT, Seshan SV

Kidney international9 Aug 2016Cited by 258 (Europe PMC)

PMID27519664 (opens in a new tab)DOI10.1016/j.kint.2016.06.013 (opens in a new tab)PepBankPUB-27519664
Publisher pagePubMedAsk about this study
Jump to 14 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice on a high-fat diet, SS‑31 preserved normal mitochondrial structure in kidney cells.

    In plain wordsIn mice on a high-fat diet, SS‑31 kept the mitochondria in kidney cells in normal shape.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial structure in kidney cells
    Study

    mousen: not reported in source

    C57BL/6 mice on a 28-week high-fat diet
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with SS-31, a tetrapeptide that targets cardiolipin and protects mitochondrial cristae structure, during high-fat diet preserved normal mitochondrial structure in all kidney cells
    1 context sentence
    Summary · context
    Here we report dramatic changes in mitochondrial structure in glomerular endothelial cells, podocytes, and proximal tubular epithelial cells after 28 weeks of a high-fat diet in C57BL/6 mice.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice on a high-fat diet, SS‑31 restored renal AMP kinase activity.

    In plain wordsIn mice on a high-fat diet, SS‑31 restored an energy-sensing enzyme activity in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRenal AMP kinase activity
    Study

    mousen: not reported in source

    C57BL/6 mice on a 28-week high-fat diet
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with SS-31, a tetrapeptide that targets cardiolipin and protects mitochondrial cristae structure, during high-fat diet preserved normal mitochondrial structure in all kidney cells, restored renal AMP kinase activity, and prevented intracellular lipid accumulation, endoplasmic reticulum stress, and apoptosis.
    1 context sentence
    Summary · context
    Here we report dramatic changes in mitochondrial structure in glomerular endothelial cells, podocytes, and proximal tubular epithelial cells after 28 weeks of a high-fat diet in C57BL/6 mice.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice on a high-fat diet, SS‑31 prevented intracellular lipid accumulation in kidney cells.

    In plain wordsIn mice on a high-fat diet, SS‑31 stopped fat building up inside kidney cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIntracellular lipid accumulation in kidney
    Study

    mousen: not reported in source

    C57BL/6 mice on a 28-week high-fat diet
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with SS-31, a tetrapeptide that targets cardiolipin and protects mitochondrial cristae structure, during high-fat diet preserved normal mitochondrial structure in all kidney cells, restored renal AMP kinase activity, and prevented intracellular lipid accumulation, endoplasmic reticulum stress, and apoptosis.
    1 context sentence
    Summary · context
    Here we report dramatic changes in mitochondrial structure in glomerular endothelial cells, podocytes, and proximal tubular epithelial cells after 28 weeks of a high-fat diet in C57BL/6 mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice on a high-fat diet, SS‑31 prevented endoplasmic reticulum stress in kidney cells.

    In plain wordsIn mice on a high-fat diet, SS‑31 prevented stress in a cell compartment of kidney cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseEndoplasmic reticulum stress in kidney
    Study

    mousen: not reported in source

    C57BL/6 mice on a 28-week high-fat diet
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with SS-31, a tetrapeptide that targets cardiolipin and protects mitochondrial cristae structure, during high-fat diet preserved normal mitochondrial structure in all kidney cells, restored renal AMP kinase activity, and prevented intracellular lipid accumulation, endoplasmic reticulum stress, and apoptosis.
    1 context sentence
    Summary · context
    Here we report dramatic changes in mitochondrial structure in glomerular endothelial cells, podocytes, and proximal tubular epithelial cells after 28 weeks of a high-fat diet in C57BL/6 mice.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice on a high-fat diet, SS‑31 prevented apoptosis in kidney cells.

    In plain wordsIn mice on a high-fat diet, SS‑31 prevented kidney cell death.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseApoptosis in kidney
    Study

    mousen: not reported in source

    C57BL/6 mice on a 28-week high-fat diet
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with SS-31, a tetrapeptide that targets cardiolipin and protects mitochondrial cristae structure, during high-fat diet preserved normal mitochondrial structure in all kidney cells, restored renal AMP kinase activity, and prevented intracellular lipid accumulation, endoplasmic reticulum stress, and apoptosis.
    1 context sentence
    Summary · context
    Here we report dramatic changes in mitochondrial structure in glomerular endothelial cells, podocytes, and proximal tubular epithelial cells after 28 weeks of a high-fat diet in C57BL/6 mice.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice on a high-fat diet, SS‑31 had no effect on weight gain.

    In plain wordsIn mice on a high-fat diet, SS‑31 did not change weight gain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeWeight gain
    Study

    mousen: not reported in source

    C57BL/6 mice on a 28-week high-fat diet
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 had no effect on weight gain, insulin resistance or hyperglycemia.
    1 context sentence
    Summary · context
    Here we report dramatic changes in mitochondrial structure in glomerular endothelial cells, podocytes, and proximal tubular epithelial cells after 28 weeks of a high-fat diet in C57BL/6 mice.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice on a high-fat diet, SS‑31 had no effect on insulin resistance.

    In plain wordsIn mice on a high-fat diet, SS‑31 did not change insulin resistance.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeInsulin resistance
    Study

    mousen: not reported in source

    C57BL/6 mice on a 28-week high-fat diet
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 had no effect on weight gain, insulin resistance or hyperglycemia.
    1 context sentence
    Summary · context
    Here we report dramatic changes in mitochondrial structure in glomerular endothelial cells, podocytes, and proximal tubular epithelial cells after 28 weeks of a high-fat diet in C57BL/6 mice.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice on a high-fat diet, SS‑31 had no effect on hyperglycemia.

    In plain wordsIn mice on a high-fat diet, SS‑31 did not change high blood sugar.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeHyperglycemia
    Study

    mousen: not reported in source

    C57BL/6 mice on a 28-week high-fat diet
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 had no effect on weight gain, insulin resistance or hyperglycemia.
    1 context sentence
    Summary · context
    Here we report dramatic changes in mitochondrial structure in glomerular endothelial cells, podocytes, and proximal tubular epithelial cells after 28 weeks of a high-fat diet in C57BL/6 mice.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice on a high-fat diet, SS‑31 prevented loss of glomerular endothelial cells and podocytes.

    In plain wordsIn mice on a high-fat diet, SS‑31 prevented loss of key kidney filter cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseLoss of glomerular endothelial cells and podocytes
    Study

    mousen: not reported in source

    C57BL/6 mice on a 28-week high-fat diet
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, SS-31 prevented loss of glomerular endothelial cells and podocytes, mesangial expansion, glomerulosclerosis, macrophage infiltration, and upregulation of proinflammatory (TNF-α, MCP-1, NF-κB) and profibrotic (TGF-β) cytokines.
    1 context sentence
    Summary · context
    Here we report dramatic changes in mitochondrial structure in glomerular endothelial cells, podocytes, and proximal tubular epithelial cells after 28 weeks of a high-fat diet in C57BL/6 mice.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In mice on a high-fat diet, SS‑31 prevented mesangial expansion.

    In plain wordsIn mice on a high-fat diet, SS‑31 prevented enlargement of a supporting tissue in the kidney filter.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMesangial expansion
    Study

    mousen: not reported in source

    C57BL/6 mice on a 28-week high-fat diet
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, SS-31 prevented loss of glomerular endothelial cells and podocytes, mesangial expansion, glomerulosclerosis, macrophage infiltration, and upregulation of proinflammatory (TNF-α, MCP-1, NF-κB) and profibrotic (TGF-β) cytokines.
    1 context sentence
    Summary · context
    Here we report dramatic changes in mitochondrial structure in glomerular endothelial cells, podocytes, and proximal tubular epithelial cells after 28 weeks of a high-fat diet in C57BL/6 mice.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In mice on a high-fat diet, SS‑31 prevented glomerulosclerosis.

    In plain wordsIn mice on a high-fat diet, SS‑31 prevented scarring of the kidney filters.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseGlomerulosclerosis
    Study

    mousen: not reported in source

    C57BL/6 mice on a 28-week high-fat diet
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, SS-31 prevented loss of glomerular endothelial cells and podocytes, mesangial expansion, glomerulosclerosis, macrophage infiltration, and upregulation of proinflammatory (TNF-α, MCP-1, NF-κB) and profibrotic (TGF-β) cytokines.
    1 context sentence
    Summary · context
    Here we report dramatic changes in mitochondrial structure in glomerular endothelial cells, podocytes, and proximal tubular epithelial cells after 28 weeks of a high-fat diet in C57BL/6 mice.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In mice on a high-fat diet, SS‑31 prevented macrophage infiltration of the kidney.

    In plain wordsIn mice on a high-fat diet, SS‑31 prevented immune cells from entering the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMacrophage infiltration in kidney
    Study

    mousen: not reported in source

    C57BL/6 mice on a 28-week high-fat diet
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, SS-31 prevented loss of glomerular endothelial cells and podocytes, mesangial expansion, glomerulosclerosis, macrophage infiltration, and upregulation of proinflammatory (TNF-α, MCP-1, NF-κB) and profibrotic (TGF-β) cytokines.
    1 context sentence
    Summary · context
    Here we report dramatic changes in mitochondrial structure in glomerular endothelial cells, podocytes, and proximal tubular epithelial cells after 28 weeks of a high-fat diet in C57BL/6 mice.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In mice on a high-fat diet, SS‑31 prevented upregulation of the proinflammatory markers TNF-α, MCP-1 and NF-κB in the kidney.

    In plain wordsIn mice on a high-fat diet, SS‑31 prevented a rise in inflammation signals in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseProinflammatory cytokines TNF-α, MCP-1 and NF-κB
    Study

    mousen: not reported in source

    C57BL/6 mice on a 28-week high-fat diet
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, SS-31 prevented loss of glomerular endothelial cells and podocytes, mesangial expansion, glomerulosclerosis, macrophage infiltration, and upregulation of proinflammatory (TNF-α, MCP-1, NF-κB) and profibrotic (TGF-β) cytokines.
    1 context sentence
    Summary · context
    Here we report dramatic changes in mitochondrial structure in glomerular endothelial cells, podocytes, and proximal tubular epithelial cells after 28 weeks of a high-fat diet in C57BL/6 mice.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In mice on a high-fat diet, SS‑31 prevented upregulation of the profibrotic cytokine TGF-β in the kidney.

    In plain wordsIn mice on a high-fat diet, SS‑31 prevented a rise in a scarring signal in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseProfibrotic cytokine TGF-β
    Study

    mousen: not reported in source

    C57BL/6 mice on a 28-week high-fat diet
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, SS-31 prevented loss of glomerular endothelial cells and podocytes, mesangial expansion, glomerulosclerosis, macrophage infiltration, and upregulation of proinflammatory (TNF-α, MCP-1, NF-κB) and profibrotic (TGF-β) cytokines.
    1 context sentence
    Summary · context
    Here we report dramatic changes in mitochondrial structure in glomerular endothelial cells, podocytes, and proximal tubular epithelial cells after 28 weeks of a high-fat diet in C57BL/6 mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.