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Study · Animal study (in vivo) · mouse · 2016

2 results

Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors.

Zhao H, Sonada S, Yoshikawa A, Ohinata K, Yoshikawa M

Peptides27 Jul 2016Cited by 8 (Europe PMC)

PMID27475912 (opens in a new tab)DOI10.1016/j.peptides.2016.07.001 (opens in a new tab)PepBankPUB-27475912
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, humanin given intracerebroventricularly exerted an anxiolytic-like activity.

    In plain wordsIn mice, humanin given into the brain ventricles produced an anxiety-reducing effect.

    Peptide
    Humanin
    Outcome
    DecreaseAnxiolytic-like activity of humanin
    Study

    mousen: not reported in source

    Mice
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    Humanin, an endogenous agonist peptide of the FPR2, exerted an anxiolytic-like activity after intracerebroventricular (icv) administration
    1 context sentence
    Summary · context
    in male mice of ddY strain.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, the anxiolytic-like activity of humanin was blocked by WRW4, an FPR2 antagonist.

    In plain wordsIn mice, a blocker of the FPR2 receptor stopped the anxiety-reducing effect of humanin.

    Peptide
    Humanin
    Outcome
    Not applicableHumanin anxiolytic-like activity with FPR2 antagonist WRW4
    Study

    mousen: not reported in source

    Mice
    Comparator
    Humanin without WRW4
    Outcome group
    Receptor activity and mechanism · Mental health and mood
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    which was also blocked by WRW4.
    1 context sentence
    Summary · context
    in male mice of ddY strain.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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