In brain tissue from multiple sclerosis patients, endogenous thymosin beta‑4 was mainly distributed at the rim of lesions.
In plain wordsIn brain tissue from people with multiple sclerosis, the body's own thymosin beta‑4 was found mainly at the edge of lesions.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- Not applicableTβ4 distribution at the rim of multiple sclerosis lesions
- Study
n = 12
- Outcome group
- Endogenous peptide levels · Nervous system and cognition
Source sentences
An ion mass, mainly distributed at the rim of multiple sclerosis lesions, was identified by liquid chromatography and tandem mass spectrometry as thymosin beta-4, a protein known to be involved in cell migration and in restorative processes.
2 context sentences(design, population, supporting numbers)
The ion mass of thymosin beta-4 was profiled by MALDI imaging mass spectrometry in brain slides of 12 multiple sclerosis patients and validated by immunohistochemical analysis.
In a pilot study we employed MALDI imaging mass spectrometry to profile and identify peptides and proteins expressed in normal-appearing white matter, grey matter and multiple sclerosis brain lesions with different extents of remyelination.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.