Effect of Thymosin beta4 on the Differentiation and Mineralization of MC3T3-E1 Cell on a Titanium Surface.

Jeong SJ, Jeong MJ

Journal of nanoscience and nanotechnology1 Feb 2016Cited by 5 (Europe PMC)

PMID27433712DOI10.1166/jnn.2016.11928PepBankPUB-27433712

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In MC3T3-E1 cells on titanium discs, Tbeta4 increased cell viability during differentiation compared with control.
In plain wordsIn cells on titanium discs, Tbeta4 raised cell viability during differentiation compared with untreated control cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCell viability during differentiation
Study
n: not reported in source
MC3T3-E1 cells differentiating on titanium discs
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Tbeta4 increased the viability of MC3T3-E1 cells during differentiation on Ti discs compared to that of the control.
1 context sentence(design, population, supporting numbers)
Summary · context
This study examined whether Tbeta4 can be a potential molecule for promoting the differentiation and mineralization of MC3T3-E1 cells on a Ti surface.
Report a problemFND-2743371201
02LabIn vitro (cells)Activity measurement
In Tbeta4-treated MC3T3-E1 cells on titanium discs, Tbeta4 mRNA and protein expression was higher than in control during differentiation.
In plain wordsIn cells on titanium discs, treated cells showed more Tbeta4 mRNA and protein than control cells during differentiation.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTbeta4 mRNA and protein expression
Study
n: not reported in source
MC3T3-E1 cells differentiating on titanium discs
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
The expression of Tbeta4 mRNA and protein in the Tbeta4-treated MC3T3-E1 cells was higher than the control during differentiation on the Ti discs.
1 context sentence(design, population, supporting numbers)
Summary · context
This study examined whether Tbeta4 can be a potential molecule for promoting the differentiation and mineralization of MC3T3-E1 cells on a Ti surface.
Report a problemFND-2743371202
03LabIn vitro (cells)Activity measurement
In MC3T3-E1 cells on titanium discs, Tbeta4 increased the formation of mineralization nodules compared with control.
In plain wordsIn cells on titanium discs, Tbeta4 increased mineral nodule formation compared with control cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseMineralization nodule formation
Study
n: not reported in source
MC3T3-E1 cells differentiating on titanium discs
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
In addition, Tbeta4 increased the formation of mineralization nodules and the mRNA expression of alkaline phosphatase (ALP), DSPP, dentin matrix protein1 (DMP1), BSP and Col I compared to that of the control in MC3T3-E1 cells during differentiation on Ti discs.
1 context sentence(design, population, supporting numbers)
Summary · context
This study examined whether Tbeta4 can be a potential molecule for promoting the differentiation and mineralization of MC3T3-E1 cells on a Ti surface.
Report a problemFND-2743371203
04LabIn vitro (cells)Activity measurement
In MC3T3-E1 cells on titanium discs, Tbeta4 increased alkaline phosphatase mRNA expression compared with control.
In plain wordsIn cells on titanium discs, Tbeta4 raised mRNA of alkaline phosphatase compared with control cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseALP mRNA expression
Study
n: not reported in source
MC3T3-E1 cells differentiating on titanium discs
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
In addition, Tbeta4 increased the formation of mineralization nodules and the mRNA expression of alkaline phosphatase (ALP), DSPP, dentin matrix protein1 (DMP1), BSP and Col I compared to that of the control in MC3T3-E1 cells during differentiation on Ti discs.
1 context sentence(design, population, supporting numbers)
Summary · context
This study examined whether Tbeta4 can be a potential molecule for promoting the differentiation and mineralization of MC3T3-E1 cells on a Ti surface.
Report a problemFND-2743371204
05LabIn vitro (cells)Activity measurement
In MC3T3-E1 cells on titanium discs, Tbeta4 increased DSPP mRNA expression compared with control.
In plain wordsIn cells on titanium discs, Tbeta4 raised DSPP mRNA compared with control cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseDSPP mRNA expression
Study
n: not reported in source
MC3T3-E1 cells differentiating on titanium discs
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
In addition, Tbeta4 increased the formation of mineralization nodules and the mRNA expression of alkaline phosphatase (ALP), DSPP, dentin matrix protein1 (DMP1), BSP and Col I compared to that of the control in MC3T3-E1 cells during differentiation on Ti discs.
1 context sentence(design, population, supporting numbers)
Summary · context
This study examined whether Tbeta4 can be a potential molecule for promoting the differentiation and mineralization of MC3T3-E1 cells on a Ti surface.
Report a problemFND-2743371205
06LabIn vitro (cells)Activity measurement
In MC3T3-E1 cells on titanium discs, Tbeta4 increased dentin matrix protein1 mRNA expression compared with control.
In plain wordsIn cells on titanium discs, Tbeta4 raised DMP1 mRNA compared with control cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseDMP1 mRNA expression
Study
n: not reported in source
MC3T3-E1 cells differentiating on titanium discs
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
In addition, Tbeta4 increased the formation of mineralization nodules and the mRNA expression of alkaline phosphatase (ALP), DSPP, dentin matrix protein1 (DMP1), BSP and Col I compared to that of the control in MC3T3-E1 cells during differentiation on Ti discs.
1 context sentence(design, population, supporting numbers)
Summary · context
This study examined whether Tbeta4 can be a potential molecule for promoting the differentiation and mineralization of MC3T3-E1 cells on a Ti surface.
Report a problemFND-2743371206
07LabIn vitro (cells)Activity measurement
In MC3T3-E1 cells on titanium discs, Tbeta4 increased bone sialoprotein mRNA expression compared with control.
In plain wordsIn cells on titanium discs, Tbeta4 raised BSP mRNA compared with control cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseBSP mRNA expression
Study
n: not reported in source
MC3T3-E1 cells differentiating on titanium discs
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
In addition, Tbeta4 increased the formation of mineralization nodules and the mRNA expression of alkaline phosphatase (ALP), DSPP, dentin matrix protein1 (DMP1), BSP and Col I compared to that of the control in MC3T3-E1 cells during differentiation on Ti discs.
1 context sentence(design, population, supporting numbers)
Summary · context
This study examined whether Tbeta4 can be a potential molecule for promoting the differentiation and mineralization of MC3T3-E1 cells on a Ti surface.
Report a problemFND-2743371207
08LabIn vitro (cells)Activity measurement
In MC3T3-E1 cells on titanium discs, Tbeta4 increased collagen type I mRNA expression compared with control.
In plain wordsIn cells on titanium discs, Tbeta4 raised collagen type I mRNA compared with control cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCol I mRNA expression
Study
n: not reported in source
MC3T3-E1 cells differentiating on titanium discs
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
In addition, Tbeta4 increased the formation of mineralization nodules and the mRNA expression of alkaline phosphatase (ALP), DSPP, dentin matrix protein1 (DMP1), BSP and Col I compared to that of the control in MC3T3-E1 cells during differentiation on Ti discs.
1 context sentence(design, population, supporting numbers)
Summary · context
This study examined whether Tbeta4 can be a potential molecule for promoting the differentiation and mineralization of MC3T3-E1 cells on a Ti surface.
Report a problemFND-2743371208

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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