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Study · Animal study (in vivo) · mouse · 2016

7 results

Nicotinamide mononucleotide inhibits post-ischemic NAD(+) degradation and dramatically ameliorates brain damage following global cerebral ischemia.

Park JH, Long A, Owens K, Kristian T

Neurobiology of disease15 Jul 2016Cited by 103 (Europe PMC)

PMID27425894 (opens in a new tab)PMCIDPMC5580241 (opens in a new tab)DOI10.1016/j.nbd.2016.07.018 (opens in a new tab)PepBankPUB-27425894
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with transient forebrain ischemia, NMN markedly reduced hippocampal CA1 injury.

    In plain wordsIn mice with brain ischemia, NMN reduced hippocampal injury compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseHippocampal CA1 injury
    Study

    mousen: not reported in source

    transient forebrain ischemia
    Comparator
    vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    62.5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    NMN (62.5mg/kg) dramatically ameliorated the hippocampal CA1 injury and significantly improved the neurological outcome.
    1 context sentence
    Summary · context
    Mice were subjected to transient forebrain ischemia and treated with NMN or vehicle at the start of reperfusion or 30min after the ischemic insult.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with transient forebrain ischemia, NMN significantly improved neurological outcome.

    In plain wordsIn mice with brain ischemia, NMN improved neurological outcome compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNeurological outcome
    Study

    mousen: not reported in source

    transient forebrain ischemia
    Comparator
    vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    62.5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    NMN (62.5mg/kg) dramatically ameliorated the hippocampal CA1 injury and significantly improved the neurological outcome.
    1 context sentence
    Summary · context
    Mice were subjected to transient forebrain ischemia and treated with NMN or vehicle at the start of reperfusion or 30min after the ischemic insult.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with transient forebrain ischemia, post-ischemic NMN prevented increased PAR formation.

    In plain wordsIn mice with brain ischemia, NMN prevented increased PAR formation compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreasePAR formation
    Study

    mousen: not reported in source

    transient forebrain ischemia
    Comparator
    vehicle
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    62.5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Additionally, the post-ischemic NMN treatment prevented the increase in PAR formation and NAD(+) catabolism.
    1 context sentence
    Summary · context
    Mice were subjected to transient forebrain ischemia and treated with NMN or vehicle at the start of reperfusion or 30min after the ischemic insult.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with transient forebrain ischemia, post-ischemic NMN prevented increased NAD catabolism.

    In plain wordsIn mice with brain ischemia, NMN prevented increased NAD breakdown compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseNAD catabolism
    Study

    mousen: not reported in source

    transient forebrain ischemia
    Comparator
    vehicle
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    62.5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Additionally, the post-ischemic NMN treatment prevented the increase in PAR formation and NAD(+) catabolism.
    1 context sentence
    Summary · context
    Mice were subjected to transient forebrain ischemia and treated with NMN or vehicle at the start of reperfusion or 30min after the ischemic insult.
  5. 05AnimalAnimal study (in vivo)Other

    In mice recovering from transient forebrain ischemia, NMN did not affect body temperature.

    In plain wordsIn mice recovering from brain ischemia, NMN did not change body temperature compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeBody temperature during recovery
    Study

    mousen: not reported in source

    transient forebrain ischemia
    Comparator
    vehicle
    Outcome group
    Overall treatment effect · Whole body
    Studied dose
    62.5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Since the NMN administration did not affect animal's temperature, blood gases or regional cerebral blood flow during recovery, the protective effect was not a result of altered reperfusion conditions.
    1 context sentence
    Summary · context
    Mice were subjected to transient forebrain ischemia and treated with NMN or vehicle at the start of reperfusion or 30min after the ischemic insult.
  6. 06AnimalAnimal study (in vivo)Other

    In mice recovering from transient forebrain ischemia, NMN did not affect blood gases.

    In plain wordsIn mice recovering from brain ischemia, NMN did not change blood gases compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeBlood gases during recovery
    Study

    mousen: not reported in source

    transient forebrain ischemia
    Comparator
    vehicle
    Outcome group
    Overall treatment effect · Whole body
    Studied dose
    62.5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Since the NMN administration did not affect animal's temperature, blood gases or regional cerebral blood flow during recovery, the protective effect was not a result of altered reperfusion conditions.
    1 context sentence
    Summary · context
    Mice were subjected to transient forebrain ischemia and treated with NMN or vehicle at the start of reperfusion or 30min after the ischemic insult.
  7. 07AnimalAnimal study (in vivo)Other

    In mice recovering from transient forebrain ischemia, NMN did not affect regional cerebral blood flow.

    In plain wordsIn mice recovering from brain ischemia, NMN did not change regional brain blood flow compared with vehicle.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeRegional cerebral blood flow during recovery
    Study

    mousen: not reported in source

    transient forebrain ischemia
    Comparator
    vehicle
    Outcome group
    Vascular function · Nervous system and cognition
    Studied dose
    62.5 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Since the NMN administration did not affect animal's temperature, blood gases or regional cerebral blood flow during recovery, the protective effect was not a result of altered reperfusion conditions.
    1 context sentence
    Summary · context
    Mice were subjected to transient forebrain ischemia and treated with NMN or vehicle at the start of reperfusion or 30min after the ischemic insult.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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