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Study · Not a test of the peptide alone · 2016

3 results

Galanin Activates G Protein Gated Inwardly Rectifying Potassium Channels and Suppresses Kisspeptin-10 Activation of GnRH Neurons.

Constantin S, Wray S

Endocrinology30 Jun 2016Cited by 22 (Europe PMC)

PMID27359210 (opens in a new tab)PMCIDPMC4967115 (opens in a new tab)DOI10.1210/en.2016-1064 (opens in a new tab)PepBankPUB-27359210
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 01LabNot a test of Kisspeptin-10 aloneEx vivo tissueMechanism

    In GnRH neuron explants, galanin 1-16 applied after kisspeptin‑10 activation rapidly suppressed the kisspeptin‑10 activation.

    In plain wordsIn lab tests on GnRH cells, galanin 1-16 quickly suppressed activation by kisspeptin‑10. This result is about galanin, not kisspeptin‑10.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseSuppression of established kp-10 activation by galanin 1-16
    Study

    n: not reported in source

    GnRH cell explants
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Applied after kp-10 activation, galanin 1-16 (Gal1-16) rapidly suppressed kp-10 activation.
    1 context sentence
    Summary · context
    GnRH cells maintained in explants, known to display spontaneous calcium oscillations, and a long-lasting calcium response to kisspeptin-10 (kp-10), were used.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 02LabNot a test of Kisspeptin-10 aloneEx vivo tissueMechanism

    In GnRH neuron explants, galanin 1-16 applied together with kisspeptin‑10 prevented kisspeptin‑10 activation until the galanin was removed.

    In plain wordsIn lab tests on GnRH cells, galanin 1-16 stopped activation by kisspeptin‑10 while it was present. This result is about galanin.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePrevention of kp-10 activation by galanin 1-16 applied together
    Study

    n: not reported in source

    GnRH cell explants
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Applied with kp-10, Gal1-16 prevented kp-10 activation until its removal.
    1 context sentence
    Summary · context
    GnRH cells maintained in explants, known to display spontaneous calcium oscillations, and a long-lasting calcium response to kisspeptin-10 (kp-10), were used.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  3. 03LabNot a test of Kisspeptin-10 aloneEx vivo tissueMechanism

    In a GnRH bioassay, galanin 1-16 decreased kisspeptin‑10-evoked GnRH secretion below the detection threshold.

    In plain wordsIn lab tests, galanin 1-16 reduced GnRH release caused by kisspeptin‑10 to below the detection limit. This result is about galanin.

    Peptide
    Kisspeptin-10
    Outcome
    Decreasekp-10-evoked GnRH secretion after galanin 1-16
    Study

    n: not reported in source

    GnRH cell explants
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    A newly developed bioassay for GnRH detection showed Gal1-16 decreased the kp-10-evoked GnRH secretion below detection threshold.
    1 context sentence
    Summary · context
    GnRH cells maintained in explants, known to display spontaneous calcium oscillations, and a long-lasting calcium response to kisspeptin-10 (kp-10), were used.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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