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Study · Not a test of the peptide alone · 2017

1 result

Actin ADP-ribosylation at Threonine148 by Photorhabdus luminescens toxin TccC3 induces aggregation of intracellular F-actin.

Lang AE, Qu Z, Schwan C, Silvan U, Unger A, Schoenenberger CA, Aktories K, Mannherz HG

Cellular microbiology15 Jul 2016Cited by 23 (Europe PMC)

PMID27341322 (opens in a new tab)DOI10.1111/cmi.12636 (opens in a new tab)PepBankPUB-27341322
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Mechanism

    In a cell-free assay, Thr148-ADP-ribosylated actin polymerized rapidly to curled F-actin bundles even in the presence of thymosin β4.

    In plain wordsIn lab tests, actin changed by a bacterial toxin still formed bundles when thymosin β4 was present.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicablePolymerization of ADP-ribosylated actin in presence of Tβ4
    Study

    n: not reported in source

    purified actin, TIRF microscopy
    Outcome group
    Receptor activity and mechanism · Whole body

    Source sentences

    Summary
    TIRF microscopy demonstrates rapid polymerization of Thr148-ADP-ribosylated actin to curled F-actin bundles even in the presence of thymosin β4, gelsolin or G1-3.
    1 context sentence
    Summary · context
    Here, we used morphological and biochemical procedures to analyse the mechanism of TccC3 intoxication.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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