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Study · Not a test of the peptide alone · 2016

4 results

A peptide from human β thymosin as a platform for the development of new anti-biofilm agents for Staphylococcus spp. and Pseudomonas aeruginosa.

Schillaci D, Spinello A, Cusimano MG, Cascioferro S, Barone G, Vitale M, Arizza V

World journal of microbiology & biotechnology23 Jun 2016Cited by 12 (Europe PMC)

PMID27339305 (opens in a new tab)DOI10.1007/s11274-016-2096-2 (opens in a new tab)PepBankPUB-27339305
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Activity measurement

    In vitro, the Tβ4 fragment EIEKFDKSKLK showed antibacterial activity against staphylococcal strains at concentrations from 12.5 to 6.2 mg/ml.

    In plain wordsIn lab tests, a piece of Tβ4 killed or stopped Staphylococcus bacteria at high concentrations.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableAntibacterial activity against staphylococcal strains
    Study

    Staphylococcus spp.n: not reported in source

    staphylococcal reference strains
    Outcome group
    Infection and antimicrobial activity · Infection

    Measurements

    active concentration
    6.2 to 12.5 mg/ml
    staphylococcal strains

    Source sentences

    Summary
    The human thymosin β4 fragment EIEKFDKSKLK showed antibacterial activity against staphylococcal strains and Pseudomonas aeruginosa ATCC 15442 at concentrations from 12.5 to 6.2 mg/ml and inhibited biofilm formation at sub-inhibitory concentrations (3.1-0.75 mg/ml).
    1 context sentence
    Summary · context
    In addition, the peptide was chemically synthesized and its antimicrobial activity was tested in vitro against planktonic and biofilm form of a group of reference strains of Staphylococcus spp. and one P. aeruginosa strain.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Activity measurement

    In vitro, the Tβ4 fragment EIEKFDKSKLK showed antibacterial activity against Pseudomonas aeruginosa ATCC 15442 at concentrations from 12.5 to 6.2 mg/ml.

    In plain wordsIn lab tests, a piece of Tβ4 stopped Pseudomonas aeruginosa bacteria at high concentrations.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableAntibacterial activity against P. aeruginosa
    Study

    Pseudomonas aeruginosan: not reported in source

    P. aeruginosa ATCC 15442
    Outcome group
    Infection and antimicrobial activity · Infection

    Measurements

    active concentration
    6.2 to 12.5 mg/ml
    P. aeruginosa ATCC 15442

    Source sentences

    Summary
    The human thymosin β4 fragment EIEKFDKSKLK showed antibacterial activity against staphylococcal strains and Pseudomonas aeruginosa ATCC 15442 at concentrations from 12.5 to 6.2 mg/ml and inhibited biofilm formation at sub-inhibitory concentrations (3.1-0.75 mg/ml).
    1 context sentence
    Summary · context
    In addition, the peptide was chemically synthesized and its antimicrobial activity was tested in vitro against planktonic and biofilm form of a group of reference strains of Staphylococcus spp. and one P. aeruginosa strain.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Activity measurement

    In vitro, the Tβ4 fragment EIEKFDKSKLK inhibited biofilm formation at sub-inhibitory concentrations.

    In plain wordsIn lab tests, a piece of Tβ4 reduced bacterial biofilm formation at low concentrations.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseBiofilm formation inhibition
    Study

    n: not reported in source

    bacterial biofilm
    Outcome group
    Infection and antimicrobial activity · Infection

    Measurements

    inhibitory concentration
    0.75 to 3.1 mg/ml
    biofilm formation

    Source sentences

    Summary
    The human thymosin β4 fragment EIEKFDKSKLK showed antibacterial activity against staphylococcal strains and Pseudomonas aeruginosa ATCC 15442 at concentrations from 12.5 to 6.2 mg/ml and inhibited biofilm formation at sub-inhibitory concentrations (3.1-0.75 mg/ml).
    1 context sentence
    Summary · context
    In addition, the peptide was chemically synthesized and its antimicrobial activity was tested in vitro against planktonic and biofilm form of a group of reference strains of Staphylococcus spp. and one P. aeruginosa strain.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 04Computer modelNot a test of Thymosin beta-4 (human) aloneIn silicoMechanism

    In a molecular dynamics simulation, the Tβ4 fragment 9-19 showed two main conformations, each with a central hydrophobic core and peripheral charged residues.

    In plain wordsIn a computer simulation, a piece of Tβ4 took two main shapes that may suit binding to cell membranes.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableConformations of Tβ4 fragment 9-19 in MD simulation
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Two main conformations of the peptide were detected, both constituted by a central hydrophobic core and by the presence of peripheral charged residues suggesting a possible mechanism of interaction with two models of biological membranes, related to eukaryotic or bacterial membrane respectively.
    1 context sentence
    Summary · context
    The fragment 9-19 of human thymosin β4 was studied through 1 μs MD simulation.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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