Skip to content

Study · Observational study · n = 49 · 2016

11 results

Efficacy and Safety of Gonadotropin-Releasing Hormone Agonist Treatment to Suppress Puberty in Gender Dysphoric Adolescents.

Schagen SE, Cohen-Kettenis PT, Delemarre-van de Waal HA, Hannema SE

The journal of sexual medicine1 Jul 2016Cited by 102 (Europe PMC)

PMID27318023 (opens in a new tab)DOI10.1016/j.jsxm.2016.05.004 (opens in a new tab)PepBankPUB-27318023
Publisher pagePubMedAsk about this study
Jump to 11 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

  1. 01HumanObservational studyEfficacy outcome

    In male-to-female adolescents receiving triptorelin, testicular volume decreased in most subjects.

    In plain wordsIn male-to-female adolescents, triptorelin treatment was linked to decreased testicular volume in most subjects.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseTesticular volume
    Study

    n = 49

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Subjects with decreased testicular volume
    43 subjects
    49 male-to-female subjects

    Source sentences

    Summary
    GnRHa treatment caused a decrease in testicular volume in 43 of 49 male-to-female subjects.
    2 context sentences
    Summary · context
    Forty-nine male-to-female and 67 female-to-male gender dysphoric adolescents treated with triptorelin were included in the analysis.
    Summary · context
    Physical examination, including assessment of Tanner stage, took place every 3 months and blood samples were drawn at 0, 3, and 6 months and then every 6 months.
  2. 02HumanObservational studyEfficacy outcome

    In female-to-male adolescents receiving triptorelin, breast development completely regressed in one subject who started at Tanner breast stage 2.

    In plain wordsIn female-to-male adolescents receiving triptorelin, breast development completely regressed in one subject who started at Tanner breast stage 2.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseBreast development regression
    Study

    n = 4

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Complete regression
    1 subject
    four subjects initially at Tanner breast stage 2

    Source sentences

    Summary
    In one of four female-to-male subjects who presented at Tanner breast stage 2, breast development completely regressed.
    2 context sentences
    Summary · context
    Forty-nine male-to-female and 67 female-to-male gender dysphoric adolescents treated with triptorelin were included in the analysis.
    Summary · context
    Physical examination, including assessment of Tanner stage, took place every 3 months and blood samples were drawn at 0, 3, and 6 months and then every 6 months.
  3. 03HumanObservational studyEfficacy outcome

    In gender dysphoric adolescents, triptorelin treatment was associated with gonadotropin suppression within 3 months.

    In plain wordsIn gender dysphoric adolescents, triptorelin treatment was linked to gonadotropin suppression within 3 months.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseGonadotropin suppression
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Gonadotropins and sex steroid levels were suppressed within 3 months.
    2 context sentences
    Summary · context
    Forty-nine male-to-female and 67 female-to-male gender dysphoric adolescents treated with triptorelin were included in the analysis.
    Summary · context
    Physical examination, including assessment of Tanner stage, took place every 3 months and blood samples were drawn at 0, 3, and 6 months and then every 6 months.
  4. 04HumanObservational studyEfficacy outcome

    In gender dysphoric adolescents, triptorelin treatment was associated with sex steroid suppression within 3 months.

    In plain wordsIn gender dysphoric adolescents, triptorelin treatment was linked to sex steroid suppression within 3 months.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseSex steroid suppression
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Gonadotropins and sex steroid levels were suppressed within 3 months.
    2 context sentences
    Summary · context
    Forty-nine male-to-female and 67 female-to-male gender dysphoric adolescents treated with triptorelin were included in the analysis.
    Summary · context
    Physical examination, including assessment of Tanner stage, took place every 3 months and blood samples were drawn at 0, 3, and 6 months and then every 6 months.
  5. 05HumanObservational studyEfficacy outcome

    In gender dysphoric adolescents receiving triptorelin, no subject required treatment adjustment for insufficient suppression.

    In plain wordsIn gender dysphoric adolescents receiving triptorelin, no subject required treatment adjustment for insufficient suppression.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableAdjustment for insufficient suppression
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment did not have to be adjusted because of insufficient suppression in any subject.
    2 context sentences
    Summary · context
    Forty-nine male-to-female and 67 female-to-male gender dysphoric adolescents treated with triptorelin were included in the analysis.
    Summary · context
    Physical examination, including assessment of Tanner stage, took place every 3 months and blood samples were drawn at 0, 3, and 6 months and then every 6 months.
  6. 06HumanObservational studySafety outcome

    In gender dysphoric adolescents receiving triptorelin, no sustained liver enzyme abnormalities occurred.

    In plain wordsIn gender dysphoric adolescents receiving triptorelin, no sustained liver enzyme abnormalities occurred.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableSustained liver enzyme abnormalities
    Study

    n: not reported in source

    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No sustained abnormalities of liver enzymes or creatinine were encountered.
    2 context sentences
    Summary · context
    Forty-nine male-to-female and 67 female-to-male gender dysphoric adolescents treated with triptorelin were included in the analysis.
    Summary · context
    Physical examination, including assessment of Tanner stage, took place every 3 months and blood samples were drawn at 0, 3, and 6 months and then every 6 months.
  7. 07HumanObservational studySafety outcome

    In gender dysphoric adolescents receiving triptorelin, no sustained creatinine abnormalities occurred.

    In plain wordsIn gender dysphoric adolescents receiving triptorelin, no sustained creatinine abnormalities occurred.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableSustained creatinine abnormalities
    Study

    n: not reported in source

    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No sustained abnormalities of liver enzymes or creatinine were encountered.
    2 context sentences
    Summary · context
    Forty-nine male-to-female and 67 female-to-male gender dysphoric adolescents treated with triptorelin were included in the analysis.
    Summary · context
    Physical examination, including assessment of Tanner stage, took place every 3 months and blood samples were drawn at 0, 3, and 6 months and then every 6 months.
  8. 08HumanObservational studyEfficacy outcome

    In gender dysphoric adolescents, triptorelin treatment was associated with decreased alkaline phosphatase.

    In plain wordsIn gender dysphoric adolescents, triptorelin treatment was linked to decreased alkaline phosphatase.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseAlkaline phosphatase
    Study

    n: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Alkaline phosphatase decreased, probably related to a slower growth velocity, because height SD score decreased in boys and girls.
    2 context sentences
    Summary · context
    Forty-nine male-to-female and 67 female-to-male gender dysphoric adolescents treated with triptorelin were included in the analysis.
    Summary · context
    Physical examination, including assessment of Tanner stage, took place every 3 months and blood samples were drawn at 0, 3, and 6 months and then every 6 months.
  9. 09HumanObservational studyEfficacy outcome

    In gender dysphoric adolescents, triptorelin treatment was associated with decreased height SD score in boys and girls.

    In plain wordsIn gender dysphoric adolescents, triptorelin treatment was linked to decreased height SD score in boys and girls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseHeight SD score
    Study

    n: not reported in source

    Outcome group
    Linear growth · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Alkaline phosphatase decreased, probably related to a slower growth velocity, because height SD score decreased in boys and girls.
    2 context sentences
    Summary · context
    Forty-nine male-to-female and 67 female-to-male gender dysphoric adolescents treated with triptorelin were included in the analysis.
    Summary · context
    Physical examination, including assessment of Tanner stage, took place every 3 months and blood samples were drawn at 0, 3, and 6 months and then every 6 months.
  10. 10HumanObservational studyEfficacy outcome

    In gender dysphoric adolescents, triptorelin treatment was associated with decreased lean body mass percentage during the first year.

    In plain wordsIn gender dysphoric adolescents, triptorelin treatment was linked to decreased lean body mass percentage during the first year.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseLean body mass percentage
    Study

    n: not reported in source

    Outcome group
    Body composition · Metabolic and weight
    Studied dose
    Dose not stated · first yearAs given in this study (human).

    Source sentences

    Summary
    Lean body mass percentage significantly decreased during the first year of treatment in girls and boys, whereas fat percentage significantly increased.
    2 context sentences
    Summary · context
    Forty-nine male-to-female and 67 female-to-male gender dysphoric adolescents treated with triptorelin were included in the analysis.
    Summary · context
    Physical examination, including assessment of Tanner stage, took place every 3 months and blood samples were drawn at 0, 3, and 6 months and then every 6 months.
  11. 11HumanObservational studyEfficacy outcome

    In gender dysphoric adolescents, triptorelin treatment was associated with increased fat percentage during the first year.

    In plain wordsIn gender dysphoric adolescents, triptorelin treatment was linked to increased fat percentage during the first year.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseFat percentage
    Study

    n: not reported in source

    Outcome group
    Body composition · Metabolic and weight
    Studied dose
    Dose not stated · first yearAs given in this study (human).

    Source sentences

    Summary
    Lean body mass percentage significantly decreased during the first year of treatment in girls and boys, whereas fat percentage significantly increased.
    2 context sentences
    Summary · context
    Forty-nine male-to-female and 67 female-to-male gender dysphoric adolescents treated with triptorelin were included in the analysis.
    Summary · context
    Physical examination, including assessment of Tanner stage, took place every 3 months and blood samples were drawn at 0, 3, and 6 months and then every 6 months.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.