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Study · In vitro (cells) · rat · 2017

4 results

Expression of GnRH and Kisspeptin in Primary Cultures of Fetal Rat Brain.

Sukhbaatar U, Kanasaki H, Mijiddorj T, Oride A, Hara T, Yamada T, Kyo S

Reproductive sciences (Thousand Oaks, Calif.)27 Sept 2016Cited by 9 (Europe PMC)

PMID27313117 (opens in a new tab)DOI10.1177/1933719116653679 (opens in a new tab)PepBankPUB-27313117
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In primary cultures of fetal rat brain, kisspeptin‑10 increased GnRH mRNA up to 1.51-fold.

    In plain wordsIn rat brain cell cultures, kisspeptin‑10 raised GnRH gene activity 1.51-fold.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGnRH mRNA after kisspeptin-10
    Study

    ratn: not reported in source

    primary cultures of fetal rat brain
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    GnRH mRNA fold change
    1.51 fold
    kisspeptin-10

    Source sentences

    Summary
    When these cultures were stimulated by kisspeptin-10, GnRH mRNA was significantly increased up to 1.51 ± 0.35-fold.
    1 context sentence
    Summary · context
    Thus, we cultured GnRH and kisspeptin neurons from whole fetal rat brain and examined the regulation of GnRH and kisspeptin.
  2. 02LabIn vitro (cells)Mechanism

    In primary cultures of fetal rat brain, kisspeptin increased kisspeptin mRNA up to 2.43-fold.

    In plain wordsIn rat brain cell cultures, kisspeptin raised kisspeptin gene activity 2.43-fold.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKisspeptin mRNA after kisspeptin
    Study

    ratn: not reported in source

    primary cultures of fetal rat brain
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Kisspeptin mRNA fold change
    2.43 fold
    kisspeptin

    Source sentences

    Summary
    Interestingly, kisspeptin mRNA was significantly increased up to 2.43 ± 0.40-fold by kisspeptin alone.
    1 context sentence
    Summary · context
    Thus, we cultured GnRH and kisspeptin neurons from whole fetal rat brain and examined the regulation of GnRH and kisspeptin.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03LabEndogenous levelIn vitro (cells)Mechanism

    In primary cultures of fetal rat brain, estradiol treatment increased kisspeptin mRNA expression 2.00-fold.

    In plain wordsIn rat brain cell cultures, estradiol raised the body's own kisspeptin gene activity two-fold.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKisspeptin mRNA after estradiol
    Study

    ratn: not reported in source

    primary cultures of fetal rat brain
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Kisspeptin mRNA fold change
    2 fold
    estradiol

    Source sentences

    Summary
    In contrast, kisspeptin mRNA expression was increased 2.00 ± 0.23-fold by E2 treatment.
    1 context sentence
    Summary · context
    Thus, we cultured GnRH and kisspeptin neurons from whole fetal rat brain and examined the regulation of GnRH and kisspeptin.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 04LabEndogenous levelIn vitro (cells)Mechanism

    In primary cultures of fetal rat brain, GnRH stimulation increased kisspeptin mRNA expression 1.46-fold.

    In plain wordsIn rat brain cell cultures, GnRH raised the body's own kisspeptin gene activity 1.46-fold.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKisspeptin mRNA after GnRH
    Study

    ratn: not reported in source

    primary cultures of fetal rat brain
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Kisspeptin mRNA fold change
    1.46 fold
    GnRH

    Source sentences

    Summary
    In addition, kisspeptin mRNA expression was significantly increased by stimulation with GnRH (1.46 ± 0.21-fold).
    1 context sentence
    Summary · context
    Thus, we cultured GnRH and kisspeptin neurons from whole fetal rat brain and examined the regulation of GnRH and kisspeptin.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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