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Study · Animal study (in vivo) · pig · 2017

3 results

Effects of liraglutide and ischemic postconditioning on myocardial salvage after I/R injury in pigs.

Ekström K, Dalsgaard M, Iversen K, Pedersen-Bjergaard U, Vejlstrup N, Diemar SS, Idorn M, Thorsteinsson B, Engstrøm T

Scandinavian cardiovascular journal : SCJ5 Jul 2016Cited by 13 (Europe PMC)

PMID27309633 (opens in a new tab)DOI10.1080/14017431.2016.1197417 (opens in a new tab)PepBankPUB-27309633
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with induced myocardial infarction, liraglutide did not change relative infarct size compared with controls (no intergroup differences).

    In plain wordsIn pigs with a heart attack, liraglutide did not change infarct size compared with controls.

    Peptide
    Liraglutide
    Outcome
    No significant changeRelative infarct size
    Study

    pign = 58

    Closed-chest pig model of 45 min LAD occlusion and reperfusion
    Comparator
    Controls and ischemic postconditioning
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intravenousAs given in this study (pig).

    Measurements

    Relative infarct size
    57%
    overall mean

    Source sentences

    Summary
    No intergroup differences in relative infarct size were detected (overall mean 57 ± 3%; p = 0.68).
    3 context sentences
    Summary · context
    In our closed-chest pig-model, we were unable to detect any cardioprotective effect of liraglutide or ischemic postconditioning either alone or combined.
    Summary · context
    Fifty-eight non-diabetic female Danish Landrace pigs (60 ± 10kg) were randomly assigned to four groups.
    Summary · context
    Group 1 (n = 14) was treated with i.v. liraglutide after 15 min of ischemia.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In pigs with induced myocardial infarction, overall mortality showed no intergroup differences between liraglutide and control groups.

    In plain wordsIn pigs with a heart attack, death rates did not differ between liraglutide and control groups.

    Peptide
    Liraglutide
    Outcome
    No significant changeOverall mortality
    Study

    pign = 58

    Closed-chest pig model of 45 min LAD occlusion and reperfusion
    Comparator
    Controls and ischemic postconditioning
    Outcome group
    Mortality · Cardiovascular
    Studied dose
    Dose not stated · intravenousAs given in this study (pig).

    Measurements

    Overall mortality
    34%
    all groups

    Source sentences

    Summary
    Overall mortality was 34% (CI 25-41%) including 26% post-intervention, with no intergroup differences (p = 0.99).
    2 context sentences
    Summary · context
    Fifty-eight non-diabetic female Danish Landrace pigs (60 ± 10kg) were randomly assigned to four groups.
    Summary · context
    Group 1 (n = 14) was treated with i.v. liraglutide after 15 min of ischemia.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In pigs with induced myocardial infarction, ventricular fibrillation occurred at similar rates across liraglutide and control groups.

    In plain wordsIn pigs with a heart attack, heart rhythm problems occurred at similar rates in liraglutide and control groups.

    Peptide
    Liraglutide
    Outcome
    No significant changeVentricular fibrillation
    Study

    pign = 58

    Closed-chest pig model of 45 min LAD occlusion and reperfusion
    Comparator
    Controls and ischemic postconditioning
    Outcome group
    Cardiovascular events · Cardiovascular
    Studied dose
    Dose not stated · intravenousAs given in this study (pig).

    Measurements

    Ventricular fibrillation occurrence
    59%
    all groups

    Source sentences

    Summary
    Occurrence of ventricular fibrillation (VF) was 59% (CI 25-80%) including 39% postintervention with no intergroup differences (p = 0.65).
    2 context sentences
    Summary · context
    Fifty-eight non-diabetic female Danish Landrace pigs (60 ± 10kg) were randomly assigned to four groups.
    Summary · context
    Group 1 (n = 14) was treated with i.v. liraglutide after 15 min of ischemia.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:10 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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