Skip to content

Study · Animal study (in vivo) · rat · 2016

3 results

[Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats.

Yuan L, Liu XJ, Han WN, Li QS, Wang ZJ, Wu MN, Yang W, Qi JS

Neuroscience bulletin15 Jun 2016Cited by 28 (Europe PMC)

PMID27306655 (opens in a new tab)PMCIDPMC5563781 (opens in a new tab)DOI10.1007/s12264-016-0041-x (opens in a new tab)PepBankPUB-27306655
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats given intrahippocampal Aβ, HNG pretreatment protected spatial learning and memory.

    In plain wordsIn rats given a toxic amyloid fragment, pretreatment with a humanin derivative protected spatial learning and memory.

    Peptide
    Humanin
    Outcome
    IncreaseSpatial learning and memory after Aβ injection
    Study

    ratn: not reported in source

    Intrahippocampal amyloid beta (Aβ31-35) injection model
    Comparator
    No HNG pretreatment
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    pretreatment with HNG not only protected spatial memory
    1 context sentence
    Summary · context
    The present study first compared the in vivo biological effects of three Aβ fragments (1-42, 31-35, and 35-31) on spatial memory in rats, and investigated the neuroprotective effects and molecular mechanisms of HNG.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats given intrahippocampal Aβ, HNG pretreatment rescued STAT3 from Aβ-induced disruption.

    In plain wordsIn rats given a toxic amyloid fragment, a humanin derivative protected the STAT3 protein from being disrupted.

    Peptide
    Humanin
    Outcome
    IncreaseSTAT3 disruption by Aβ
    Study

    ratn: not reported in source

    Intrahippocampal amyloid beta (Aβ31-35) injection model
    Comparator
    No HNG pretreatment
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but also rescued STAT3 from Aβ-induced disruption; and the neuroprotective effects of HNG were effectively counteracted by genistein, a specific tyrosine kinase inhibitor.
    1 context sentence
    Summary · context
    The present study first compared the in vivo biological effects of three Aβ fragments (1-42, 31-35, and 35-31) on spatial memory in rats, and investigated the neuroprotective effects and molecular mechanisms of HNG.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats given intrahippocampal Aβ, genistein, a tyrosine kinase inhibitor, counteracted the neuroprotective effects of HNG.

    In plain wordsIn rats given a toxic amyloid fragment, a tyrosine kinase blocker cancelled the protective effect of a humanin derivative.

    Peptide
    Humanin
    Outcome
    Not applicableHNG neuroprotection with genistein
    Study

    ratn: not reported in source

    Intrahippocampal amyloid beta (Aβ31-35) injection model
    Comparator
    HNG without genistein
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the neuroprotective effects of HNG were effectively counteracted by genistein, a specific tyrosine kinase inhibitor.
    1 context sentence
    Summary · context
    The present study first compared the in vivo biological effects of three Aβ fragments (1-42, 31-35, and 35-31) on spatial memory in rats, and investigated the neuroprotective effects and molecular mechanisms of HNG.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.