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Study · Animal study (in vivo) · mouse · 2016

6 results

Mitochondrial therapy improves limb perfusion and myopathy following hindlimb ischemia.

Ryan TE, Schmidt CA, Alleman RJ, Tsang AM, Green TD, Neufer PD, Brown DA, McClung JM

Journal of molecular and cellular cardiology1 Jun 2016Cited by 32 (Europe PMC)

PMID27262673 (opens in a new tab)PMCIDPMC5002368 (opens in a new tab)DOI10.1016/j.yjmcc.2016.05.015 (opens in a new tab)PepBankPUB-27262673
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with hindlimb ischemia, MTP-131 rescued limb muscle capillary density compared with vehicle.

    In plain wordsIn mice with a blocked leg artery, MTP-131 restored small blood vessel density in leg muscle compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseLimb muscle capillary density
    Study

    mousen: not reported in source

    BALB/c mice with hindlimb ischemia
    Comparator
    Vehicle control
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared to vehicle control, MTP-131 rescued limb muscle capillary density and blood flow (64.7±11% of contralateral vs. 39.9±4%), and improved muscle regeneration.
    1 context sentence
    Summary · context
    BALB/c mice were treated with a therapeutic mitochondrial-targeting peptide (MTP-131) and subjected to limb ischemia (HLI).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with hindlimb ischemia, MTP-131 rescued limb blood flow to 64.7% of the contralateral limb versus 39.9% with vehicle.

    In plain wordsIn mice with a blocked leg artery, MTP-131 restored more leg blood flow than vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseLimb blood flow
    Study

    mousen: not reported in source

    BALB/c mice with hindlimb ischemia
    Comparator
    Vehicle control
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    Blood flow, percent of contralateral limb
    64.7%
    MTP-131
    Blood flow, percent of contralateral limb
    39.9%
    vehicle

    Source sentences

    Summary
    Compared to vehicle control, MTP-131 rescued limb muscle capillary density and blood flow (64.7±11% of contralateral vs. 39.9±4%), and improved muscle regeneration.
    1 context sentence
    Summary · context
    BALB/c mice were treated with a therapeutic mitochondrial-targeting peptide (MTP-131) and subjected to limb ischemia (HLI).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with hindlimb ischemia, MTP-131 improved muscle regeneration compared with vehicle.

    In plain wordsIn mice with a blocked leg artery, MTP-131 improved muscle regrowth compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMuscle regeneration
    Study

    mousen: not reported in source

    BALB/c mice with hindlimb ischemia
    Comparator
    Vehicle control
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and improved muscle regeneration.
    1 context sentence
    Summary · context
    BALB/c mice were treated with a therapeutic mitochondrial-targeting peptide (MTP-131) and subjected to limb ischemia (HLI).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with hindlimb ischemia, MTP-131 increased electron transport system flux across all conditions at day 7.

    In plain wordsIn mice with a blocked leg artery, MTP-131 raised the energy-making activity of muscle mitochondria at day 7.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseElectron transport system flux at HLI day-7
    Study

    mousen: not reported in source

    BALB/c mice with hindlimb ischemia
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTP-131 also increased electron transport system flux across all conditions at HLI day-7.
    1 context sentence
    Summary · context
    BALB/c mice were treated with a therapeutic mitochondrial-targeting peptide (MTP-131) and subjected to limb ischemia (HLI).
  5. 05LabIn vitro (cells)Mechanism

    In primary muscle cells exposed to experimental ischemia, MTP-131 rescued the reduced cellular respiration during recovery.

    In plain wordsIn lab-grown muscle cells deprived of oxygen, MTP-131 restored cell energy use during recovery.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRespiration of primary muscle cells after experimental ischemia
    Study

    n: not reported in source

    Primary muscle cells exposed to experimental ischemia
    Comparator
    Untreated ischemic cells
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, primary muscle cells exposed to experimental ischemia demonstrated markedly reduced (~75%) cellular respiration, which was rescued by MTP-131 during a recovery period.
  6. 06LabIn vitro (cells)Mechanism

    In HUVEC endothelial cells, MTP-131 enhanced respiration.

    In plain wordsIn lab-grown blood vessel cells, MTP-131 raised cell energy use.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRespiration of endothelial cells (HUVEC) after experimental ischemia
    Study

    humann: not reported in source

    HUVEC endothelial cells exposed to experimental ischemia
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared to muscle cells, endothelial cell (HUVEC) respiration was inherently protected from ischemia (~30% reduction), but was also enhanced by MTP-131.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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