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Study · Animal study (in vivo) · rat · 2016

4 results

Kisspeptin in the medial amygdala and sexual behavior in male rats.

Gresham R, Li S, Adekunbi DA, Hu M, Li XF, O'Byrne KT

Neuroscience letters24 May 2016Cited by 56 (Europe PMC)

PMID27233219 (opens in a new tab)PMCIDPMC4944646 (opens in a new tab)DOI10.1016/j.neulet.2016.05.042 (opens in a new tab)PepBankPUB-27233219
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Summary

The medial amygdala (MeA) is crucial for sexual behavior; kisspeptin (Kiss1) also plays a role in sexual function. Kisspeptin receptor (Kiss1r) knockout mice display no sexual behavior. Recently Kiss1 and Kiss1r have been discovered in the posterodorsal subnucleus of the medial amygdala (MePD). We hypothesised that Kiss1 in the MePD may have an influence on male sexual behavior. To test this we bilaterally cannulated the MePD and infused kisspeptin-10 in male rats. This caused the rats to have multiple erections, an effect specific to Kiss1 receptor activation, because Kiss1r antagonism blocked the erectile response. When Kiss1 was infused into the lateral cerebroventricle, there were no observed erections. We also measured the plasma levels of LH when Kiss1 is infused into the MePD or lateral cerebroventricle; Kiss1 increased plasma LH to comparable levels when infused into both sites. We conclude that Kiss1 has a role in male sexual behavior, which is specific to the MePD.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, kisspeptin‑10 infused into the posterodorsal medial amygdala caused multiple erections.

    In plain wordsIn male rats, kisspeptin‑10 infused into a brain area called the medial amygdala caused multiple erections.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseErections after MePD infusion
    Study

    ratn: not reported in source

    Male rats with cannulae
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · bilateral infusion into the posterodorsal medial amygdalaAs given in this study (rat).

    Source sentences

    Summary
    This caused the rats to have multiple erections
    1 context sentence
    Summary · context
    To test this we bilaterally cannulated the MePD and infused kisspeptin-10 in male rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In male rats, Kiss1r antagonism blocked the erectile response to kisspeptin‑10 infused into the medial amygdala.

    In plain wordsIn male rats, blocking the kisspeptin receptor stopped the erections caused by kisspeptin‑10 in the medial amygdala.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKiss1r antagonism of kisspeptin-induced erections
    Study

    ratn: not reported in source

    Male rats with cannulae
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · bilateral infusion into the posterodorsal medial amygdalaAs given in this study (rat).

    Source sentences

    Summary
    This caused the rats to have multiple erections, an effect specific to Kiss1 receptor activation, because Kiss1r antagonism blocked the erectile response.
    1 context sentence
    Summary · context
    To test this we bilaterally cannulated the MePD and infused kisspeptin-10 in male rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, kisspeptin‑10 infused into the lateral cerebroventricle caused no observed erections.

    In plain wordsIn male rats, kisspeptin‑10 infused into a brain fluid space caused no erections.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeErections after lateral cerebroventricle infusion
    Study

    ratn: not reported in source

    Male rats with cannulae
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · lateral cerebroventricleAs given in this study (rat).

    Source sentences

    Summary
    When Kiss1 was infused into the lateral cerebroventricle, there were no observed erections.
    1 context sentence
    Summary · context
    To test this we bilaterally cannulated the MePD and infused kisspeptin-10 in male rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, kisspeptin‑10 increased plasma LH to comparable levels when infused into the medial amygdala or the lateral cerebroventricle.

    In plain wordsIn male rats, kisspeptin‑10 raised luteinizing hormone by similar amounts whether infused into the medial amygdala or a brain fluid space.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH after MePD or lateral cerebroventricle infusion
    Study

    ratn: not reported in source

    Male rats with cannulae
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · posterodorsal medial amygdala or lateral cerebroventricleAs given in this study (rat).

    Source sentences

    Summary
    We also measured the plasma levels of LH when Kiss1 is infused into the MePD or lateral cerebroventricle; Kiss1 increased plasma LH to comparable levels when infused into both sites.
    1 context sentence
    Summary · context
    To test this we bilaterally cannulated the MePD and infused kisspeptin-10 in male rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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