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Study · Animal study (in vivo) · rat · 2016

9 results

The glucagon like peptide 1 analogue, exendin-4, attenuates oxidative stress-induced retinal cell death in early diabetic rats through promoting Sirt1 and Sirt3 expression.

Zeng Y, Yang K, Wang F, Zhou L, Hu Y, Tang M, Zhang S, Jin S, Zhang J, Wang J, Li W, Lu L, Xu GT

Experimental eye research20 May 2016Cited by 54 (Europe PMC)

PMID27212443 (opens in a new tab)DOI10.1016/j.exer.2016.05.002 (opens in a new tab)PepBankPUB-27212443
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In early diabetic rats, retinal cell death decreased after intravitreal exendin‑4 treatment.

    In plain wordsIn diabetic rats, retinal cell death decreased after exendin‑4 treatment compared with the diabetic condition.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseRetinal cell death
    Study

    ratn: not reported in source

    Early-stage streptozotocin-diabetic rat retina
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated · intravitreal · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    Four days after intravitreal EX4 treatment, retinal cell death and ROS level in retinas reduced significantly, and visual function was recovered.
    1 context sentence
    Summary · context
    EX4 was injected intravitreally into normal and early-stage streptozotocin-diabetic rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In early diabetic rats, retinal ROS decreased after intravitreal exendin‑4 treatment.

    In plain wordsIn diabetic rats, retinal oxidative stress decreased after exendin‑4 treatment compared with the diabetic condition.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseRetinal ROS
    Study

    ratn: not reported in source

    Early-stage streptozotocin-diabetic rat retina
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated · intravitreal · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    Four days after intravitreal EX4 treatment, retinal cell death and ROS level in retinas reduced significantly, and visual function was recovered.
    1 context sentence
    Summary · context
    EX4 was injected intravitreally into normal and early-stage streptozotocin-diabetic rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In early diabetic rats, visual function recovered after intravitreal exendin‑4 treatment.

    In plain wordsIn diabetic rats, visual function recovered after exendin‑4 treatment compared with the diabetic condition.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseVisual function
    Study

    ratn: not reported in source

    Early-stage streptozotocin-diabetic rat retina
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated · intravitreal · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    Four days after intravitreal EX4 treatment, retinal cell death and ROS level in retinas reduced significantly, and visual function was recovered.
    1 context sentence
    Summary · context
    EX4 was injected intravitreally into normal and early-stage streptozotocin-diabetic rats.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In early diabetic rats, intravitreal exendin‑4 restored reduced retinal Sirt1 expression to normal levels.

    In plain wordsIn diabetic rats, exendin‑4 restored retinal Sirt1 levels compared with the reduced diabetic levels.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseRetinal Sirt1 expression
    Study

    ratn: not reported in source

    Early-stage streptozotocin-diabetic rat retina
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated · intravitrealAs given in this study (rat).

    Source sentences

    Summary
    In the retinas of early-stage diabetic rats, the expressions of Sirt1 and Sirt3 were also found to be significantly decreased, and both were back to normal levels after intravitreal injection of EX4.
    1 context sentence
    Summary · context
    EX4 was injected intravitreally into normal and early-stage streptozotocin-diabetic rats.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In early diabetic rats, intravitreal exendin‑4 restored reduced retinal Sirt3 expression to normal levels.

    In plain wordsIn diabetic rats, exendin‑4 restored retinal Sirt3 levels compared with the reduced diabetic levels.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseRetinal Sirt3 expression
    Study

    ratn: not reported in source

    Early-stage streptozotocin-diabetic rat retina
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated · intravitrealAs given in this study (rat).

    Source sentences

    Summary
    In the retinas of early-stage diabetic rats, the expressions of Sirt1 and Sirt3 were also found to be significantly decreased, and both were back to normal levels after intravitreal injection of EX4.
    1 context sentence
    Summary · context
    EX4 was injected intravitreally into normal and early-stage streptozotocin-diabetic rats.
  6. 06LabIn vitro (cells)Mechanism

    In H2O2-treated R28 cells, exendin‑4 increased Sirt1 expression.

    In plain wordsIn cells exposed to hydrogen peroxide, exendin‑4 increased Sirt1 compared with hydrogen peroxide alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseCellular Sirt1 expression
    Study

    n: not reported in source

    H2O2-treated R28 cells
    Comparator
    H2O2 treatment without EX4
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    With the addition of EX4 into the culture system, the expressions of Sirt1 and Sirt3 were increased, and the H2O2-induced ROS and cell death were significantly reduced.
    1 context sentence
    Summary · context
    In R28 cells, hydrogen peroxide (H2O2) treatment increased ROS and cell death and decreased Sirt1 and Sirt3.
  7. 07LabIn vitro (cells)Mechanism

    In H2O2-treated R28 cells, exendin‑4 increased Sirt3 expression.

    In plain wordsIn cells exposed to hydrogen peroxide, exendin‑4 increased Sirt3 compared with hydrogen peroxide alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseCellular Sirt3 expression
    Study

    n: not reported in source

    H2O2-treated R28 cells
    Comparator
    H2O2 treatment without EX4
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    With the addition of EX4 into the culture system, the expressions of Sirt1 and Sirt3 were increased, and the H2O2-induced ROS and cell death were significantly reduced.
    1 context sentence
    Summary · context
    In R28 cells, hydrogen peroxide (H2O2) treatment increased ROS and cell death and decreased Sirt1 and Sirt3.
  8. 08LabIn vitro (cells)Efficacy outcome

    In H2O2-treated R28 cells, exendin‑4 reduced ROS.

    In plain wordsIn cells exposed to hydrogen peroxide, exendin‑4 reduced oxidative stress compared with hydrogen peroxide alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseCellular ROS
    Study

    n: not reported in source

    H2O2-treated R28 cells
    Comparator
    H2O2 treatment without EX4
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    With the addition of EX4 into the culture system, the expressions of Sirt1 and Sirt3 were increased, and the H2O2-induced ROS and cell death were significantly reduced.
    1 context sentence
    Summary · context
    In R28 cells, hydrogen peroxide (H2O2) treatment increased ROS and cell death and decreased Sirt1 and Sirt3.
  9. 09LabIn vitro (cells)Efficacy outcome

    In H2O2-treated R28 cells, exendin‑4 reduced cell death.

    In plain wordsIn cells exposed to hydrogen peroxide, exendin‑4 reduced cell death compared with hydrogen peroxide alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseCell death
    Study

    n: not reported in source

    H2O2-treated R28 cells
    Comparator
    H2O2 treatment without EX4
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    With the addition of EX4 into the culture system, the expressions of Sirt1 and Sirt3 were increased, and the H2O2-induced ROS and cell death were significantly reduced.
    1 context sentence
    Summary · context
    In R28 cells, hydrogen peroxide (H2O2) treatment increased ROS and cell death and decreased Sirt1 and Sirt3.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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