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Study · In vitro (cells) · 2016

3 results

Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors.

Yang Z, Tao YX

Biochimica et biophysica acta18 May 2016Cited by 41 (Europe PMC)

PMID27208795 (opens in a new tab)DOI10.1016/j.bbadis.2016.05.008 (opens in a new tab)PepBankPUB-27208795
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In GT1-7 cells, NDP-MSH induced significant AKT phosphorylation.

    In plain wordsIn cells, NDP-MSH increased AKT phosphorylation in GT1-7 cells.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseAKT phosphorylation in GT1-7 cells
    Study

    n: not reported in source

    GT1-7 cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both NDP-MSH and AgRP treatment induced significant AKT phosphorylation in GT1-7 cells but not in MC3R- or MC4R-transfected HEK293T cells.
    1 context sentence
    Summary · context
    In the present study, we sought to determine the potential of AgRP to regulate the activation of intracellular kinases, including extracellular signal-regulated kinase 1 and 2 (ERK1/2), AKT and AMP-activated protein kinase (AMPK), through neural MCRs.
  2. 02LabIn vitro (cells)Mechanism

    In MC3R- or MC4R-transfected HEK293T cells, NDP-MSH did not induce significant AKT phosphorylation.

    In plain wordsIn cells, NDP-MSH did not change AKT phosphorylation in HEK293T cells carrying the MC3R or MC4R receptor.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeAKT phosphorylation in MC3R- or MC4R-transfected HEK293T cells
    Study

    n: not reported in source

    MC3R- or MC4R-transfected HEK293T cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both NDP-MSH and AgRP treatment induced significant AKT phosphorylation in GT1-7 cells but not in MC3R- or MC4R-transfected HEK293T cells.
    1 context sentence
    Summary · context
    In the present study, we sought to determine the potential of AgRP to regulate the activation of intracellular kinases, including extracellular signal-regulated kinase 1 and 2 (ERK1/2), AKT and AMP-activated protein kinase (AMPK), through neural MCRs.
  3. 03LabIn vitro (cells)Mechanism

    In GT1-7 cells and HEK293T cells transfected with neural melanocortin receptors, NDP-MSH significantly decreased phosphorylated AMPK levels.

    In plain wordsIn cells, NDP-MSH lowered phosphorylated AMPK levels.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseAMPK phosphorylation in GT1-7 and HEK293T cells
    Study

    n: not reported in source

    GT1-7 cells and HEK293T cells transfected with neural MCRs
    Comparator
    AgRP
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The phosphorylated AMPK levels in both GT1-7 cells and HERK293T cells transfected with neural MCRs were significantly decreased upon stimulation with NDP-MSH but not with AgRP.
    1 context sentence
    Summary · context
    In the present study, we sought to determine the potential of AgRP to regulate the activation of intracellular kinases, including extracellular signal-regulated kinase 1 and 2 (ERK1/2), AKT and AMP-activated protein kinase (AMPK), through neural MCRs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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