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Study · Animal study (in vivo) · rat · 2012

3 results

Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus.

Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C

Journal of experimental pharmacology19 Oct 2012Cited by 4 (Europe PMC)

PMID27186127 (opens in a new tab)PMCIDPMC4863553 (opens in a new tab)DOI10.2147/jep.s35396 (opens in a new tab)PepBankPUB-27186127
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats after abdominal surgery, intravenous ipamorelin accelerated gastric emptying versus vehicle, leaving less of the meal in the stomach.

    In plain wordsIn rats after abdominal surgery, ipamorelin sped up stomach emptying compared with vehicle.

    Peptide
    Ipamorelin
    Outcome
    DecreaseGastric emptying (meal remaining in stomach at 15 min)
    Study

    ratn: not reported in source

    Comparator
    Vehicle
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    0.014 µmol/kg · intravenousAs given in this study (rat).

    Measurements

    Meal remaining in stomach
    52%
    ipamorelin 0.014 µmol/kg
    Meal remaining in stomach
    78%
    vehicle
    Meal remaining in stomach
    44%
    nonsurgical controls

    Source sentences

    Summary
    Abdominal surgery caused a delay in gastric emptying with 78% ± 5% of the meal remaining in the stomach in vehicle controls. Ipamorelin (0.014 µmol/kg intravenous) resulted in a significant acceleration (P < 0.05 vs vehicle-treated rat) of gastric emptying with 52% ± 11% of the meal remaining in the…
    1 context sentence
    Summary · context
    Fasted adult male rats were subjected to laparotomy and intestinal manipulation.
  2. 02LabEx vivo tissueEfficacy outcome

    In isolated rat gastric fundus tissue after surgery, ipamorelin reversed the inhibition of acetylcholine-induced contractions.

    In plain wordsIn lab tests on rat stomach tissue, ipamorelin reversed the loss of contraction caused by surgery.

    Peptide
    Ipamorelin
    Outcome
    IncreaseAcetylcholine-induced gastric smooth muscle contraction
    Study

    ratn: not reported in source

    isolated gastric fundus segments in organ bath after laparotomy and intestinal manipulation
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    1 µMAs given in this study (rat).

    Source sentences

    Summary
    Following abdominal surgery and intestinal manipulation, isolated preparations of gastric smooth muscle exhibited a marked inhibition of acetylcholine and electrical field stimulation-induced contractile responses, which were reversed by ipamorelin and ghrelin.
    1 context sentence
    Summary · context
    In a separate group of rats subjected to laparotomy and intestinal manipulation, the gastric fundus was isolated and tissue segments were suspended in an organ bath to assess the effect of ipamorelin (1 µM) on gastric smooth muscle contractility induced by acetylcholine and electrical field stimulation.
  3. 03LabEx vivo tissueEfficacy outcome

    In isolated rat gastric fundus tissue after surgery, ipamorelin reversed the inhibition of electrical field stimulation-induced contractions.

    In plain wordsIn lab tests on rat stomach tissue, ipamorelin reversed the loss of nerve-stimulated contraction caused by surgery.

    Peptide
    Ipamorelin
    Outcome
    IncreaseElectrical field stimulation-induced gastric smooth muscle contraction
    Study

    ratn: not reported in source

    isolated gastric fundus segments in organ bath after laparotomy and intestinal manipulation
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    1 µMAs given in this study (rat).

    Source sentences

    Summary
    Following abdominal surgery and intestinal manipulation, isolated preparations of gastric smooth muscle exhibited a marked inhibition of acetylcholine and electrical field stimulation-induced contractile responses, which were reversed by ipamorelin and ghrelin.
    1 context sentence
    Summary · context
    In a separate group of rats subjected to laparotomy and intestinal manipulation, the gastric fundus was isolated and tissue segments were suspended in an organ bath to assess the effect of ipamorelin (1 µM) on gastric smooth muscle contractility induced by acetylcholine and electrical field stimulation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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