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Study · Animal study (in vivo) · rat · 2016

7 results

Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death.

Wang X, Hu X, Yang Y, Takata T, Sakurai T

Brain research26 Apr 2016Cited by 179 (Europe PMC)

PMID27130898 (opens in a new tab)DOI10.1016/j.brainres.2016.04.060 (opens in a new tab)PepBankPUB-27130898
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with Aβ oligomer infusion, NMN sustained improvement in Morris water maze cognitive function.

    In plain wordsIn rats given Aβ oligomers, NMN sustained improved cognitive function in the Morris water maze.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMorris water maze cognitive function
    Study

    ratn: not reported in source

    Aβ oligomer infusion rat model of Alzheimer's disease
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    500 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Treatment of intracerebroventricular Aβ oligomer infusion AD model rats with NMN (500mg/kg, intraperitoneally) sustained improvement in cognitive function as assessed by the Morris water maze.
  2. 02LabEx vivo tissueEfficacy outcome

    In Aβ oligomer-treated hippocampal slice cultures, NMN attenuated neuronal cell death.

    In plain wordsIn lab tests, NMN reduced nerve cell death in hippocampal slices exposed to Aβ oligomers.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseNeuronal cell death
    Study

    n: not reported in source

    Aβ oligomer-treated organotypic hippocampal slice cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In OHCs, Aβ oligomer-treated culture media with NMN attenuated neuronal cell death.
  3. 03LabEx vivo tissueMechanism

    In hippocampal slice cultures, NMN significantly prevented Aβ oligomer-induced inhibition of long-term potentiation.

    In plain wordsIn lab tests, NMN prevented Aβ oligomers from inhibiting long-term potentiation in hippocampal slices.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseLong-term potentiation inhibition
    Study

    n: not reported in source

    Aβ oligomer-treated organotypic hippocampal slice cultures
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN treatment also significantly prevented the Aβ oligomer-induced inhibition of LTP.
    1 context sentence
    Summary · context
    To determine whether improving brain energy metabolism will forestall disease progress in AD, the impact of the NAD(+) precursor NMN on Aβ oligomer-induced neuronal death and cognitive impairment were studied in organotypic hippocampal slice cultures (OHCs) and in a rat model of AD.
  4. 04LabEx vivo tissueMechanism

    In Aβ oligomer-treated hippocampal slices, NMN restored NAD levels.

    In plain wordsIn lab tests, NMN restored NAD levels in hippocampal slices exposed to Aβ oligomers.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNAD levels
    Study

    n: not reported in source

    Aβ oligomer-treated organotypic hippocampal slice cultures
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN restored levels of NAD(+) and ATP, eliminated accumulation of reactive oxygen species (ROS) in the Aβ oligomer-treated hippocampal slices.
  5. 05LabEx vivo tissueMechanism

    In Aβ oligomer-treated hippocampal slices, NMN restored ATP levels.

    In plain wordsIn lab tests, NMN restored ATP levels in hippocampal slices exposed to Aβ oligomers.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseATP levels
    Study

    n: not reported in source

    Aβ oligomer-treated organotypic hippocampal slice cultures
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN restored levels of NAD(+) and ATP, eliminated accumulation of reactive oxygen species (ROS) in the Aβ oligomer-treated hippocampal slices.
  6. 06LabEx vivo tissueMechanism

    In Aβ oligomer-treated hippocampal slices, NMN eliminated ROS accumulation.

    In plain wordsIn lab tests, NMN eliminated reactive oxygen species accumulation in hippocampal slices exposed to Aβ oligomers.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseROS accumulation
    Study

    n: not reported in source

    Aβ oligomer-treated organotypic hippocampal slice cultures
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN restored levels of NAD(+) and ATP, eliminated accumulation of reactive oxygen species (ROS) in the Aβ oligomer-treated hippocampal slices.

Studies that did not test the peptide alone1

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 07LabNot a test of NMN (nicotinamide mononucleotide) aloneEx vivo tissueMechanism

    In Aβ oligomer-treated hippocampal slices, 3-acetylpyridine reversed the protective effects of NMN.

    In plain wordsIn lab tests, 3-acetylpyridine reversed NMN's reported protective effects against Aβ oligomers.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableReversal of NMN protective effects by 3-acetylpyridine
    Study

    n: not reported in source

    Aβ oligomer-treated organotypic hippocampal slice cultures
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    All these protective effects were reversed by 3-acetylpyridine, which generates inactive NAD(+).

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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