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Study · Measured the body's own peptide · 2016

8 results

Serum Thymosin β4 Concentrations in Obstructive Sleep Apnea Syndrome Patients.

Liu Y, Liu M, Shi Y, Liu Y

Journal of clinical laboratory analysis18 Apr 2016

PMID27086675 (opens in a new tab)PMCIDPMC6807183 (opens in a new tab)DOI10.1002/jcla.21930 (opens in a new tab)PepBankPUB-27086675
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Natural levels measured8

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In a cross-sectional study, serum Tβ4 concentrations were higher in patients with obstructive sleep apnea syndrome than in healthy controls.

    In plain wordsPatients with sleep apnea had higher levels of the body's own Tβ4 in blood than healthy people.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSerum Tβ4 in OSAS patients versus controls
    Study

    n = 252

    Comparator
    Healthy subjects
    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    Elevated serum thymosin β4 concentrations were found in OSAS patients than the controls.
    1 context sentence
    Summary · context
    Serum thymosin β4 concentrations were examined in a cross-sectional population including 158 patients with OSAS and 94 healthy subjects.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Multivariable logistic regression showed a significant association between serum Tβ4 concentrations and OSAS development.

    In plain wordsHigher natural Tβ4 levels in blood were linked to having sleep apnea.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableAssociation of serum Tβ4 with OSAS development
    Study

    n = 252

    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    Multivariable logistic regression analysis indicated a significant association between serum thymosin β4 concentrations and OSAS development.
    1 context sentence
    Summary · context
    Serum thymosin β4 concentrations were examined in a cross-sectional population including 158 patients with OSAS and 94 healthy subjects.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In OSAS patients, serum Tβ4 correlated with homeostasis model assessment of insulin resistance in simple linear regression.

    In plain wordsIn people with sleep apnea, natural Tβ4 levels were linked to a measure of insulin resistance.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCorrelation of serum Tβ4 with HOMA-IR in OSAS patients
    Study

    n = 158

    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    Simple linear regression analyses showed that serum thymosin β4 in OSAS patients was correlated with homeostasis model assessment of insulin resistance, apnea hypopnea index, disease severity, and osteoarthritis development.
    1 context sentence
    Summary · context
    Serum thymosin β4 concentrations were examined in a cross-sectional population including 158 patients with OSAS and 94 healthy subjects.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In OSAS patients, serum Tβ4 correlated with the apnea hypopnea index in simple linear regression.

    In plain wordsIn people with sleep apnea, natural Tβ4 levels were linked to the number of breathing pauses.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCorrelation of serum Tβ4 with apnea hypopnea index in OSAS patients
    Study

    n = 158

    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    Simple linear regression analyses showed that serum thymosin β4 in OSAS patients was correlated with homeostasis model assessment of insulin resistance, apnea hypopnea index, disease severity, and osteoarthritis development.
    1 context sentence
    Summary · context
    Serum thymosin β4 concentrations were examined in a cross-sectional population including 158 patients with OSAS and 94 healthy subjects.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    In OSAS patients, serum Tβ4 correlated with osteoarthritis development in simple linear regression.

    In plain wordsIn people with sleep apnea, natural Tβ4 levels were linked to osteoarthritis.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCorrelation of serum Tβ4 with osteoarthritis development in OSAS patients
    Study

    n = 158

    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Simple linear regression analyses showed that serum thymosin β4 in OSAS patients was correlated with homeostasis model assessment of insulin resistance, apnea hypopnea index, disease severity, and osteoarthritis development.
    1 context sentence
    Summary · context
    Serum thymosin β4 concentrations were examined in a cross-sectional population including 158 patients with OSAS and 94 healthy subjects.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelObservational studyOther

    In multiple stepwise regression, only disease severity remained associated with serum Tβ4 in OSAS patients.

    In plain wordsAfter adjustment, only disease severity stayed linked to natural Tβ4 levels in people with sleep apnea.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableIndependent predictor of serum Tβ4 in multiple stepwise regression
    Study

    n = 158

    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    Then multiple stepwise regression analysis showed that only disease severity remained to be associated with serum thymosin β4.
    1 context sentence
    Summary · context
    Serum thymosin β4 concentrations were examined in a cross-sectional population including 158 patients with OSAS and 94 healthy subjects.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  7. 07HumanEndogenous levelObservational studyOther

    Serum Tβ4 concentrations were higher in patients with severe OSAS than in patients with mild and moderate OSAS.

    In plain wordsPatients with severe sleep apnea had higher natural Tβ4 levels in blood than those with milder disease.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSerum Tβ4 in severe versus mild and moderate OSAS
    Study

    n: not reported in source

    Comparator
    Mild and moderate OSAS patients
    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    Severe OSAS patients showed increased serum thymosin β4 concentrations compared with mild and moderate patients.
    1 context sentence
    Summary · context
    Serum thymosin β4 concentrations were examined in a cross-sectional population including 158 patients with OSAS and 94 healthy subjects.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  8. 08HumanEndogenous levelObservational studyOther

    Serum Tβ4 concentrations correlated with the severity of OSAS in Spearman correlation analysis.

    In plain wordsNatural Tβ4 levels in blood were linked to how severe the sleep apnea was.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCorrelation of serum Tβ4 with OSAS severity
    Study

    n: not reported in source

    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    Spearman correlation analysis suggested that serum thymosin β4 concentrations were correlated with the severity of OSAS.
    1 context sentence
    Summary · context
    Serum thymosin β4 concentrations were examined in a cross-sectional population including 158 patients with OSAS and 94 healthy subjects.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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