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Study · In vitro (cells) · spotted scat (receptor) · 2016

3 results

Molecular cloning, tissue distribution, and pharmacological characterization of melanocortin-4 receptor in spotted scat, Scatophagus argus.

Li JT, Yang Z, Chen HP, Zhu CH, Deng SP, Li GL, Tao YX

General and comparative endocrinology11 Apr 2016Cited by 37 (Europe PMC)

PMID27080551 (opens in a new tab)DOI10.1016/j.ygcen.2016.04.010 (opens in a new tab)PepBankPUB-27080551
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In assays of spotted scat MC4R, NDP-MSH bound the receptor with the highest affinity, followed by ACTH (1-24) and alpha-MSH.

    In plain wordsIn lab tests, NDP-MSH bound the spotted scat MC4R receptor more strongly than ACTH or alpha-MSH.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableBinding affinity to spotted scat MC4R
    Study

    spotted scat (receptor)n: not reported in source

    SAMC4R pharmacological assays
    Comparator
    ACTH (1-24), alpha-MSH
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results showed that SAMC4R bound NDP-MSH with the highest affinity followed by ACTH (1-24) and α-MSH.
    1 context sentence
    Summary · context
    We herein reported on the cloning, tissue distribution, and pharmacological characterization of spotted scat (Scatophagus argus) MC4R (SAMC4R).
  2. 02LabIn vitro (cells)Activity measurement

    The spotted scat MC4R showed a similar ligand ranking to human MC4R, with two to five-fold higher affinities for these ligands including NDP-MSH.

    In plain wordsIn lab tests, the spotted scat receptor bound NDP-MSH and the other ligands two to five times more strongly than the human receptor.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableAffinity at spotted scat MC4R versus human MC4R
    Study

    spotted scat (receptor)n: not reported in source

    SAMC4R pharmacological assays
    Comparator
    Human MC4R
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results showed that SAMC4R bound NDP-MSH with the highest affinity followed by ACTH (1-24) and α-MSH. Similar ranking was also found for hMC4R, although SAMC4R had two to five-fold higher affinities for these ligands.
    1 context sentence
    Summary · context
    We herein reported on the cloning, tissue distribution, and pharmacological characterization of spotted scat (Scatophagus argus) MC4R (SAMC4R).
  3. 03LabIn vitro (cells)Activity measurement

    In assays of spotted scat MC4R, NDP-MSH was a potent agonist that stimulated cAMP generation.

    In plain wordsIn lab tests, NDP-MSH strongly raised cAMP through the spotted scat MC4R receptor.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreasecAMP generation via spotted scat MC4R
    Study

    spotted scat (receptor)n: not reported in source

    SAMC4R pharmacological assays
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    α-MSH, NDP-MSH, and ACTH (1-24) were identified as potent agonists to stimulate cAMP generation followed by THIQ in SAMC4R.
    1 context sentence
    Summary · context
    We herein reported on the cloning, tissue distribution, and pharmacological characterization of spotted scat (Scatophagus argus) MC4R (SAMC4R).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

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  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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