Triptorelin and cetrorelix induce immune responses and affect uterine development and expressions of genes and proteins of ESR1, LHR, and FSHR of mice.

Wei S, Guo H, Gong Z, Zhang F, Ma Z

Immunopharmacology and immunotoxicology14 Apr 2016Cited by 11 (Europe PMC)

PMID27075695DOI10.3109/08923973.2016.1168432PepBankPUB-27075695

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone12

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

01AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In mice, TRI-2 antigen immunization reduced uterine weight compared with controls.
In plain wordsIn mice, TRI-2 antigen immunization reduced uterine weight compared with controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseUterine weight with TRI-2
Study
micen: not reported in source
Uterine development after TRI antigen immunization
Comparator
Control group
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Uterine weight reduction
28.57%
TRI-2
Source sentences
Summary
Uterine weights of TRI-2, TRI-3 reduced by 28.57% and 11.43% (p < 0.05), respectively.
3 context sentences(design, population, supporting numbers)
Summary · context
The study investigated the effects of active immunity of GnRH agonist and antagonist on uterine development, microstructures, expression of hormone receptors mRNAs, and proteins in uteri.
Summary · context
One hundred and five mice were assigned into CET, TRI, and control groups (CG).
Summary · context
Mice in TRI-1, TRI-2, and TRI-3 were injected with 10, 20, and 40 μg TRI antigens for seven days, respectively.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2707569501
02AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In mice, TRI-3 antigen immunization reduced uterine weight compared with controls.
In plain wordsIn mice, TRI-3 antigen immunization reduced uterine weight compared with controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseUterine weight with TRI-3
Study
micen: not reported in source
Uterine development after TRI antigen immunization
Comparator
Control group
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Uterine weight reduction
11.43%
TRI-3
Source sentences
Summary
Uterine weights of TRI-2, TRI-3 reduced by 28.57% and 11.43% (p < 0.05), respectively.
3 context sentences(design, population, supporting numbers)
Summary · context
The study investigated the effects of active immunity of GnRH agonist and antagonist on uterine development, microstructures, expression of hormone receptors mRNAs, and proteins in uteri.
Summary · context
One hundred and five mice were assigned into CET, TRI, and control groups (CG).
Summary · context
Mice in TRI-1, TRI-2, and TRI-3 were injected with 10, 20, and 40 μg TRI antigens for seven days, respectively.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2707569502
03AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In mice, the uterine cavity narrowed slightly in the TRI-1 antigen group.
In plain wordsIn mice, the uterine cavity narrowed slightly in the TRI-1 antigen group.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseUterine cavity width
Study
micen: not reported in source
Uterine development after TRI antigen immunization
Comparator
Control group
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Uterine cavity became narrow slightly in TRI-1.
3 context sentences(design, population, supporting numbers)
Summary · context
The study investigated the effects of active immunity of GnRH agonist and antagonist on uterine development, microstructures, expression of hormone receptors mRNAs, and proteins in uteri.
Summary · context
One hundred and five mice were assigned into CET, TRI, and control groups (CG).
Summary · context
Mice in TRI-1, TRI-2, and TRI-3 were injected with 10, 20, and 40 μg TRI antigens for seven days, respectively.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2707569503
04AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In mice, uterine gland counts decreased in the TRI antigen group.
In plain wordsIn mice, uterine gland counts decreased in the TRI antigen group.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseUterine gland count
Study
micen: not reported in source
Uterine development after TRI antigen immunization
Comparator
Control group
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Numbers of uterine glands reduced.
4 context sentences(design, population, supporting numbers)
Summary · context
In TRI group, the uterine wall thinned.
Summary · context
The study investigated the effects of active immunity of GnRH agonist and antagonist on uterine development, microstructures, expression of hormone receptors mRNAs, and proteins in uteri.
Summary · context
One hundred and five mice were assigned into CET, TRI, and control groups (CG).
Summary · context
Mice in TRI-1, TRI-2, and TRI-3 were injected with 10, 20, and 40 μg TRI antigens for seven days, respectively.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2707569504
05AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In mice, endometrial epithelial thickness decreased in the TRI-1 antigen group.
In plain wordsIn mice, endometrial epithelial thickness decreased in the TRI-1 antigen group.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseEndometrial epithelial thickness
Study
micen: not reported in source
Uterine development after TRI antigen immunization
Comparator
Control group
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Endometrial epithelial thickness decrease
13.69%
TRI-1
Source sentences
Summary
EET in TRI-1 was decreased by 13.69%.
3 context sentences(design, population, supporting numbers)
Summary · context
The study investigated the effects of active immunity of GnRH agonist and antagonist on uterine development, microstructures, expression of hormone receptors mRNAs, and proteins in uteri.
Summary · context
One hundred and five mice were assigned into CET, TRI, and control groups (CG).
Summary · context
Mice in TRI-1, TRI-2, and TRI-3 were injected with 10, 20, and 40 μg TRI antigens for seven days, respectively.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2707569505
06AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In mice, TRI-1 antigen immunization reduced uterine wall thickness compared with controls.
In plain wordsIn mice, TRI-1 antigen immunization reduced uterine wall thickness compared with controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseUterine wall thickness with TRI-1
Study
micen: not reported in source
Uterine development after TRI antigen immunization
Comparator
Control group
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Uterine wall thickness reduction
29.35%
TRI-1
Source sentences
Summary
UWT of TRI-1, TRI-2, and TRI-3 reduced by 29.35, 15.36, and 14.41%, respectively.
3 context sentences(design, population, supporting numbers)
Summary · context
The study investigated the effects of active immunity of GnRH agonist and antagonist on uterine development, microstructures, expression of hormone receptors mRNAs, and proteins in uteri.
Summary · context
One hundred and five mice were assigned into CET, TRI, and control groups (CG).
Summary · context
Mice in TRI-1, TRI-2, and TRI-3 were injected with 10, 20, and 40 μg TRI antigens for seven days, respectively.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2707569506
07AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In mice, TRI-2 antigen immunization reduced uterine wall thickness compared with controls.
In plain wordsIn mice, TRI-2 antigen immunization reduced uterine wall thickness compared with controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseUterine wall thickness with TRI-2
Study
micen: not reported in source
Uterine development after TRI antigen immunization
Comparator
Control group
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Uterine wall thickness reduction
15.36%
TRI-2
Source sentences
Summary
UWT of TRI-1, TRI-2, and TRI-3 reduced by 29.35, 15.36, and 14.41%, respectively.
3 context sentences(design, population, supporting numbers)
Summary · context
The study investigated the effects of active immunity of GnRH agonist and antagonist on uterine development, microstructures, expression of hormone receptors mRNAs, and proteins in uteri.
Summary · context
One hundred and five mice were assigned into CET, TRI, and control groups (CG).
Summary · context
Mice in TRI-1, TRI-2, and TRI-3 were injected with 10, 20, and 40 μg TRI antigens for seven days, respectively.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2707569507
08AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In mice, TRI-3 antigen immunization reduced uterine wall thickness compared with controls.
In plain wordsIn mice, TRI-3 antigen immunization reduced uterine wall thickness compared with controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseUterine wall thickness with TRI-3
Study
micen: not reported in source
Uterine development after TRI antigen immunization
Comparator
Control group
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Uterine wall thickness reduction
14.41%
TRI-3
Source sentences
Summary
UWT of TRI-1, TRI-2, and TRI-3 reduced by 29.35, 15.36, and 14.41%, respectively.
3 context sentences(design, population, supporting numbers)
Summary · context
The study investigated the effects of active immunity of GnRH agonist and antagonist on uterine development, microstructures, expression of hormone receptors mRNAs, and proteins in uteri.
Summary · context
One hundred and five mice were assigned into CET, TRI, and control groups (CG).
Summary · context
Mice in TRI-1, TRI-2, and TRI-3 were injected with 10, 20, and 40 μg TRI antigens for seven days, respectively.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2707569508
09AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In mice, ESR1, FSHR, and LHR mRNA expression increased with TRI antigen immunization.
In plain wordsIn mice, ESR1, FSHR, and LHR mRNA expression increased with TRI antigen immunization.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseReceptor mRNA expression
Study
micen: not reported in source
Uterine development after TRI antigen immunization
Comparator
Control group
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Expressions of ESR1, FSHR, and LHR mRNAs in CET and TRI mice increased.
3 context sentences(design, population, supporting numbers)
Summary · context
The study investigated the effects of active immunity of GnRH agonist and antagonist on uterine development, microstructures, expression of hormone receptors mRNAs, and proteins in uteri.
Summary · context
One hundred and five mice were assigned into CET, TRI, and control groups (CG).
Summary · context
Mice in TRI-1, TRI-2, and TRI-3 were injected with 10, 20, and 40 μg TRI antigens for seven days, respectively.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2707569509
10AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In mice, TRI antigen immunization increased ESR1 protein, with the maximum in TRI-3.
In plain wordsIn mice, TRI antigen immunization increased ESR1 protein, with the maximum in TRI-3.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseESR1 protein
Study
micen: not reported in source
Uterine development after TRI antigen immunization
Comparator
Control group
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
ESR1 and FSHR protein levels increased in all experimental mice (p < 0.05), with a maximum of TRI-3.
3 context sentences(design, population, supporting numbers)
Summary · context
The study investigated the effects of active immunity of GnRH agonist and antagonist on uterine development, microstructures, expression of hormone receptors mRNAs, and proteins in uteri.
Summary · context
One hundred and five mice were assigned into CET, TRI, and control groups (CG).
Summary · context
Mice in TRI-1, TRI-2, and TRI-3 were injected with 10, 20, and 40 μg TRI antigens for seven days, respectively.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2707569510
11AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In mice, TRI antigen immunization increased FSHR protein, with the maximum in TRI-3.
In plain wordsIn mice, TRI antigen immunization increased FSHR protein, with the maximum in TRI-3.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseFSHR protein
Study
micen: not reported in source
Uterine development after TRI antigen immunization
Comparator
Control group
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
ESR1 and FSHR protein levels increased in all experimental mice (p < 0.05), with a maximum of TRI-3.
3 context sentences(design, population, supporting numbers)
Summary · context
The study investigated the effects of active immunity of GnRH agonist and antagonist on uterine development, microstructures, expression of hormone receptors mRNAs, and proteins in uteri.
Summary · context
One hundred and five mice were assigned into CET, TRI, and control groups (CG).
Summary · context
Mice in TRI-1, TRI-2, and TRI-3 were injected with 10, 20, and 40 μg TRI antigens for seven days, respectively.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2707569511
12AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In mice, TRI antigen immunization increased LHR protein, with the maximum in TRI-3.
In plain wordsIn mice, TRI antigen immunization increased LHR protein, with the maximum in TRI-3.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseLHR protein
Study
micen: not reported in source
Uterine development after TRI antigen immunization
Comparator
Control group
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
LHR protein levels of TRI group increased, with a maximum of TRI-3 (p < 0.05).
3 context sentences(design, population, supporting numbers)
Summary · context
The study investigated the effects of active immunity of GnRH agonist and antagonist on uterine development, microstructures, expression of hormone receptors mRNAs, and proteins in uteri.
Summary · context
One hundred and five mice were assigned into CET, TRI, and control groups (CG).
Summary · context
Mice in TRI-1, TRI-2, and TRI-3 were injected with 10, 20, and 40 μg TRI antigens for seven days, respectively.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2707569512

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 16:35 UTC
Study data updated · source update from Europe PMC
Version 2
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.