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Study · Animal study (in vivo) · mouse · 2016

4 results

Kisspeptin 10 inhibits the Warburg effect in breast cancer through the Smad signaling pathway: both in vitro and in vivo.

Song GQ, Zhao Y

American journal of translational research15 Jan 2016Cited by 12 (Europe PMC)

PMID27069552 (opens in a new tab)PMCIDPMC4759428 (opens in a new tab)PepBankPUB-27069552
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice with breast cancer xenografts, the effects of kisspeptin‑10 on the Warburg effect and related mechanisms were confirmed.

    In plain wordsIn mice with human breast cancer grafts, kisspeptin‑10 gave effects similar to those seen in cells.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseWarburg effect and related mechanisms in xenografts
    Study

    mousen: not reported in source

    Murine xenograft
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effects and related mechanisms of these treatments were also confirmed in murine xenografts.
    1 context sentence
    Summary · context
    We also demonstrated a shorter fragment of KISS1, Kisspeptin-10 (KP-10), inhibited the Warburg effect and induced mitochondrial injury in human breast cancer cell line, MDA-MB-231.
  2. 02LabIn vitro (cells)Mechanism

    In human MDA-MB-231 breast cancer cells, kisspeptin‑10 inhibited the Warburg effect.

    In plain wordsIn human breast cancer cells in a lab dish, kisspeptin‑10 reduced the Warburg effect, a cancer-type way of using sugar.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseWarburg effect
    Study

    humann: not reported in source

    MDA-MB-231 breast cancer cell line
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kisspeptin-10 (KP-10), inhibited the Warburg effect and induced mitochondrial injury in human breast cancer cell line, MDA-MB-231.
  3. 03LabIn vitro (cells)Mechanism

    In human MDA-MB-231 breast cancer cells, kisspeptin‑10 induced mitochondrial injury.

    In plain wordsIn human breast cancer cells in a lab dish, kisspeptin‑10 caused damage to mitochondria, the cell's energy units.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseMitochondrial injury
    Study

    humann: not reported in source

    MDA-MB-231 breast cancer cell line
    Outcome group
    Mitochondrial function · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kisspeptin-10 (KP-10), inhibited the Warburg effect and induced mitochondrial injury in human breast cancer cell line, MDA-MB-231.
  4. 04LabIn vitro (cells)Mechanism

    In human MDA-MB-231 breast cancer cells, kisspeptin‑10 inhibited the Warburg effect by activating the Smad pathway.

    In plain wordsIn human breast cancer cells in a lab dish, kisspeptin‑10 reduced the Warburg effect by switching on the Smad pathway.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSmad pathway activation
    Study

    humann: not reported in source

    MDA-MB-231 breast cancer cell line
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We confirmed that KP-10-inhibited the Warburg effect by activating Smad pathway.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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