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Study · Animal study (in vivo) · rat · 2016

4 results

Humanin prevents brain mitochondrial dysfunction in a cardiac ischaemia-reperfusion injury model.

Kumfu S, Charununtakorn ST, Jaiwongkam T, Chattipakorn N, Chattipakorn SC

Experimental physiology1 Jun 2016Cited by 25 (Europe PMC)

PMID27059110 (opens in a new tab)DOI10.1113/ep085749 (opens in a new tab)PepBankPUB-27059110
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cardiac ischaemia-reperfusion injury, humanin given before ischaemia attenuated brain mitochondrial dysfunction.

    In plain wordsIn rats with heart injury, humanin given before the blockage reduced damage to brain mitochondria.

    Peptide
    Humanin
    Outcome
    DecreaseBrain mitochondrial dysfunction after cardiac I/R, humanin before ischaemia
    Study

    ratn: not reported in source

    Cardiac ischaemia-reperfusion injury (Wistar rats)
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    84 μg kg(-1) · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Only the humanin treatment before ischaemia attenuated brain mitochondrial dysfunction, but it did not prevent BBB breakdown or brain oxidative stress.
    2 context sentences
    Summary · context
    Forty-two male Wistar rats were divided into the following two groups: an I/R group, which was subjected to a 30 min left anterior descending coronary artery occlusion followed by 120 min reperfusion (I/R group; n = 36); and a sham group (n = 6).
    Summary · context
    Each subgroup was given either vehicle or humanin analogue (84 μg kg(-1) , i.v.) at three different time points, namely before ischaemia, during ischaemia or at the onset of reperfusion.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cardiac ischaemia-reperfusion injury, humanin given before ischaemia did not prevent blood-brain barrier breakdown.

    In plain wordsIn rats with heart injury, humanin given before the blockage did not stop the blood-brain barrier from breaking down.

    Peptide
    Humanin
    Outcome
    No significant changeBlood-brain barrier breakdown after cardiac I/R, humanin before ischaemia
    Study

    ratn: not reported in source

    Cardiac ischaemia-reperfusion injury (Wistar rats)
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    84 μg kg(-1) · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Only the humanin treatment before ischaemia attenuated brain mitochondrial dysfunction, but it did not prevent BBB breakdown or brain oxidative stress.
    2 context sentences
    Summary · context
    Forty-two male Wistar rats were divided into the following two groups: an I/R group, which was subjected to a 30 min left anterior descending coronary artery occlusion followed by 120 min reperfusion (I/R group; n = 36); and a sham group (n = 6).
    Summary · context
    Each subgroup was given either vehicle or humanin analogue (84 μg kg(-1) , i.v.) at three different time points, namely before ischaemia, during ischaemia or at the onset of reperfusion.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cardiac ischaemia-reperfusion injury, humanin given before ischaemia did not prevent brain oxidative stress.

    In plain wordsIn rats with heart injury, humanin given before the blockage did not prevent oxidative stress in the brain.

    Peptide
    Humanin
    Outcome
    No significant changeBrain oxidative stress after cardiac I/R, humanin before ischaemia
    Study

    ratn: not reported in source

    Cardiac ischaemia-reperfusion injury (Wistar rats)
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    84 μg kg(-1) · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Only the humanin treatment before ischaemia attenuated brain mitochondrial dysfunction, but it did not prevent BBB breakdown or brain oxidative stress.
    2 context sentences
    Summary · context
    Forty-two male Wistar rats were divided into the following two groups: an I/R group, which was subjected to a 30 min left anterior descending coronary artery occlusion followed by 120 min reperfusion (I/R group; n = 36); and a sham group (n = 6).
    Summary · context
    Each subgroup was given either vehicle or humanin analogue (84 μg kg(-1) , i.v.) at three different time points, namely before ischaemia, during ischaemia or at the onset of reperfusion.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cardiac ischaemia-reperfusion injury, humanin given during ischaemia or in the reperfusion period provided no neuroprotection.

    In plain wordsIn rats with heart injury, humanin given during the blockage or after blood flow returned did not protect the brain.

    Peptide
    Humanin
    Outcome
    No significant changeNeuroprotection when humanin was given during ischaemia or at reperfusion
    Study

    ratn: not reported in source

    Cardiac ischaemia-reperfusion injury (Wistar rats)
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    84 μg kg(-1) · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Humanin treatment during ischaemia and in the reperfusion period provided no neuroprotection.
    2 context sentences
    Summary · context
    Forty-two male Wistar rats were divided into the following two groups: an I/R group, which was subjected to a 30 min left anterior descending coronary artery occlusion followed by 120 min reperfusion (I/R group; n = 36); and a sham group (n = 6).
    Summary · context
    Each subgroup was given either vehicle or humanin analogue (84 μg kg(-1) , i.v.) at three different time points, namely before ischaemia, during ischaemia or at the onset of reperfusion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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