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Study · In vitro (cells) · sheep · 2016

3 results

Relationships between leptin, KiSS-1/GPR54 expression and TSH secretion from pituitary cells of pubertal ewes in vitro.

Radwańska P, Kosior-Korzecka U

Research in veterinary science23 Feb 2016Cited by 13 (Europe PMC)

PMID27033929 (opens in a new tab)DOI10.1016/j.rvsc.2016.02.014 (opens in a new tab)PepBankPUB-27033929
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In pituitary cells of pubertal ewes in vitro, kisspeptin‑10 did not change TSH secretion except for a short-term influence after 2 h.

    In plain wordsIn sheep pituitary cells in lab tests, kisspeptin‑10 did not change TSH release, apart from a short effect after 2 hours.

    Peptide
    Kisspeptin-10
    Outcome
    MixedTSH secretion
    Study

    sheepn: not reported in source

    Pituitary cells of pubertal ewes in vitro
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    10(-11)-10(-5) MAs given in this study (sheep).

    Source sentences

    Summary
    Kisspeptin-10 did not change TSH secretion, except exerting a short-term influence after 2h.
    1 context sentence
    Summary · context
    Cells were cultured in McCoy's 5A medium without hormones; with 10(-10)-10(-5)M of leptin; with 10(-11)-10(-5)M of kisspeptin-10; with peptide 234 (10(-7)M, antagonist of GPR54) or 10(-11)-10(-5)M of kisspeptin-10 and peptide 234.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02LabEndogenous levelIn vitro (cells)Mechanism

    In pituitary cells of pubertal ewes in vitro, leptin directly affected secretion of the cells' own kisspeptin‑10.

    In plain wordsIn sheep pituitary cells in lab tests, leptin changed how much of the cells' own kisspeptin‑10 was released.

    Peptide
    Kisspeptin-10
    Outcome
    Direction not reportedKisspeptin-10 secretion after leptin
    Study

    sheepn: not reported in source

    Pituitary cells of pubertal ewes in vitro
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    We found that leptin directly affected kisspeptin-10 secretion and kisspeptin-1/GPR54 expression in pituitary cells of pubertal ewes.
    1 context sentence
    Summary · context
    Cells were cultured in McCoy's 5A medium without hormones; with 10(-10)-10(-5)M of leptin; with 10(-11)-10(-5)M of kisspeptin-10; with peptide 234 (10(-7)M, antagonist of GPR54) or 10(-11)-10(-5)M of kisspeptin-10 and peptide 234.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 03LabEndogenous levelIn vitro (cells)Mechanism

    In pituitary cells of pubertal ewes in vitro, leptin directly affected expression of the cells' own kisspeptin-1 and GPR54.

    In plain wordsIn sheep pituitary cells in lab tests, leptin changed the activity of the cells' own kisspeptin and receptor genes.

    Peptide
    Kisspeptin-10
    Outcome
    Direction not reportedKiSS-1 and GPR54 expression after leptin
    Study

    sheepn: not reported in source

    Pituitary cells of pubertal ewes in vitro
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    We found that leptin directly affected kisspeptin-10 secretion and kisspeptin-1/GPR54 expression in pituitary cells of pubertal ewes.
    1 context sentence
    Summary · context
    Cells were cultured in McCoy's 5A medium without hormones; with 10(-10)-10(-5)M of leptin; with 10(-11)-10(-5)M of kisspeptin-10; with peptide 234 (10(-7)M, antagonist of GPR54) or 10(-11)-10(-5)M of kisspeptin-10 and peptide 234.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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