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Study · Animal study (in vivo) · dog · 2016

5 results

The effects of kisspeptin agonist canine KP-10 and kisspeptin antagonist p271 on plasma LH concentrations during different stages of the estrous cycle and anestrus in the bitch.

Albers-Wolthers CH, de Gier J, Rutten VP, van Kooten PJ, Leegwater PA, Schaefers-Okkens AC, Kooistra HS

Theriogenology23 Feb 2016Cited by 13 (Europe PMC)

PMID27020879 (opens in a new tab)DOI10.1016/j.theriogenology.2016.02.009 (opens in a new tab)PepBankPUB-27020879
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult Beagle bitches, intravenous canine KP-10 increased plasma LH during all stages of the estrous cycle and in anestrus.

    In plain wordsIn female dogs, KP-10 raised blood LH at all stages of the cycle and in anestrus.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH after canine KP-10
    Study

    dogn = 12

    Adult Beagle bitches
    Comparator
    Pre-administration baseline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.5 μg/kg body weight · intravenousAs given in this study (dog).

    Source sentences

    Summary
    Canine KP-10 induced an increase of plasma LH concentration during all estrous cycle stages and anestrus.
    2 context sentences
    Summary · context
    Two groups of six adult Beagle bitches were used.
    Summary · context
    In one group, plasma LH concentration was determined before (40 and 0 minutes) and 10, 20, 40, and 60 minutes after the intravenous administration of 0.5-μg/kg body weight (BW) canine KP-10.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In bitches, the LH response to KP-10 (AUC and increment) in the follicular phase was lower than in anestrus.

    In plain wordsIn female dogs, the LH rise after KP-10 was smaller in the follicular phase than in anestrus.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseLH AUC and increment, follicular phase vs anestrus
    Study

    dogn = 12

    Adult Beagle bitches
    Comparator
    Anestrus
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.5 μg/kg body weight · intravenousAs given in this study (dog).

    Source sentences

    Summary
    The area under the curve (AUC) for LH and LH increment in the follicular phase were lower than those in anestrus.
    2 context sentences
    Summary · context
    Two groups of six adult Beagle bitches were used.
    Summary · context
    In one group, plasma LH concentration was determined before (40 and 0 minutes) and 10, 20, 40, and 60 minutes after the intravenous administration of 0.5-μg/kg body weight (BW) canine KP-10.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In bitches, the LH response to KP-10 in the first half of the luteal phase was lower than in the second half of the luteal phase and in anestrus.

    In plain wordsIn female dogs, the LH rise after KP-10 was smaller in the first half of the luteal phase than later or in anestrus.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseLH AUC and increment, first half of luteal phase vs second half and anestrus
    Study

    dogn = 12

    Adult Beagle bitches
    Comparator
    Second half of luteal phase and anestrus
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.5 μg/kg body weight · intravenousAs given in this study (dog).

    Source sentences

    Summary
    The AUC LH and LH increment in the first half of the luteal phase were lower than those in the second half of the luteal phase and anestrus.
    2 context sentences
    Summary · context
    Two groups of six adult Beagle bitches were used.
    Summary · context
    In one group, plasma LH concentration was determined before (40 and 0 minutes) and 10, 20, 40, and 60 minutes after the intravenous administration of 0.5-μg/kg body weight (BW) canine KP-10.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In bitches, the LH response to KP-10 in the second half of the luteal phase did not differ from that in anestrus.

    In plain wordsIn female dogs, the LH rise after KP-10 in the second half of the luteal phase was not different from that in anestrus.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLH AUC and increment, second half of luteal phase vs anestrus
    Study

    dogn = 12

    Adult Beagle bitches
    Comparator
    Anestrus
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.5 μg/kg body weight · intravenousAs given in this study (dog).

    Source sentences

    Summary
    The AUC LH and LH increment in the second half of the luteal phase were not different from those in anestrus.
    2 context sentences
    Summary · context
    Two groups of six adult Beagle bitches were used.
    Summary · context
    In one group, plasma LH concentration was determined before (40 and 0 minutes) and 10, 20, 40, and 60 minutes after the intravenous administration of 0.5-μg/kg body weight (BW) canine KP-10.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 05AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In bitches, continuous intravenous p271 did not alter basal LH and did not prevent or lower the LH response to KP-10 in any cycle stage or in anestrus.

    In plain wordsIn female dogs, the antagonist p271 did not block or reduce the LH rise caused by KP-10 at any stage tested.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLH response to KP-10 during p271 infusion
    Study

    dogn = 12

    Adult Beagle bitches
    Comparator
    KP-10 without p271
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Continuous administration of the antagonist p271 did not alter basal plasma LH concentration and could not prevent or lower the LH response to KP-10 in any of the cycle stages and anestrus.
    1 context sentence
    Summary · context
    In the other group, the bitches received a continuous intravenous infusion with p271 (50 μg/kg BW/h) for 3 hours, and 0.5-μg/kg BW canine KP-10 was administered intravenously 2 hours after the start of the p271 infusion.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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